Results 21 to 30 of about 43,591 (296)
Aquaporin-4 autoimmunity [PDF]
Neurology Neuroimmunology & Neuroinflammation, 2015 Neuromyelitis optica (NMO) and a related spectrum of inflammatory CNS disorders are unified by detection of a serum autoantibody specific for the aquaporin-4 (AQP4) water channel, which is abundant in astrocytic foot processes. The classic clinical manifestations of NMO are optic neuritis and longitudinally extensive transverse myelitis.
Zekeridou, Anastasia, Lennon, Vanda A.
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Aquaporin-4 and Cognitive Disorders
Aging and disease, 2022 Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral part of the glymphatic system that cannot be ignored. The CNS has the glymphatic system instead of the conventional lymphatic system.
Wang, Yifan +3 more
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Aquaporin 4 as a NH3 Channel [PDF]
Journal of Biological Chemistry, 2016 Ammonia is a biologically potent molecule, and the regulation of ammonia levels in the mammalian body is, therefore, strictly controlled. The molecular paths of ammonia permeation across plasma membranes remain ill-defined, but the structural similarity of water and NH3 has pointed to the aquaporins as putative NH3-permeable pores. Accordingly, a range
Assentoft, Mette +5 more
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Aquaporin-4 and brain edema [PDF]
Pediatric Nephrology, 2007 Aquaporin-4 (AQP4) is a water-channel protein expressed strongly in the brain, predominantly in astrocyte foot processes at the borders between the brain parenchyma and major fluid compartments, including cerebrospinal fluid (CSF) and blood. This distribution suggests that AQP4 controls water fluxes into and out of the brain parenchyma.
Papadopoulos, MC, Verkman, AS
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Isolated dysphagia due to aquaporin-4 autoimmunity
The Turkish Journal of Gastroenterology, 2012 İstanbul Bilim Üniversitesi, Tıp Fakültesi.Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease that affects the spinal cord and optic nerves and is associated with aquaporin- 4 antibodies (Aqp-4 Ab).
Editorial Office
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Aquaporin-4 and Cerebrovascular Diseases [PDF]
International Journal of Molecular Sciences, 2016 Cerebrovascular diseases are conditions caused by problems with brain vasculature, which have a high morbidity and mortality. Aquaporin-4 (AQP4) is the most abundant water channel in the brain and crucial for the formation and resolution of brain edema.
Chu, Heling +7 more
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Aquaporin 4 and neuromyelitis optica [PDF]
The Lancet Neurology, 2012 Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) and the evidence that AQP4-IgG is involved in the development of neuromyelitis optica revolutionised our understanding of the disease.
Marios C, Papadopoulos, A S, Verkman
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Aquaporins in spinal cord injury: the janus face of aquaporin 4 [PDF]
Neuroscience, 2010 Although malfunction of spinal cord water channels (aquaporins, AQP) likely contributes to severe disturbances in ion/water homeostasis after spinal cord injury (SCI), their roles are still poorly understood. Here we report and discuss the potential significance of changes in the AQP4 expression in human SCI that generates glial fibrillary acidic ...
Taylor,, Olivera Nesic +8 more
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Rinsho Shinkeigaku, 2008 In human body, there are thirteen water channels but their expression patterns are tissue specific. Aquaporin-4 (AQP4) is a predominantly expressed water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder, and mesial temporal lobe epilepsy.
Tani, Kazutoshi +2 more
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Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression [PDF]
Research Results in Pharmacology, 2022 Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl
Mahardian Rahmadi +9 more
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