Results 41 to 50 of about 43,591 (296)

Table_1_Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.docx

, 2022
BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914), Wenjuan Huang (707703), Qiang Dong (380835), Lei Zhou (19808), Junhui Xia (12324599), Jianhua Ma (486317), Lei Du (14992), Bei Wang (116772), Fang Li (41162), Chongbo Zhao (4705297), Chao Quan (449518), Jie Yang (121778), Jingzi ZhangBao (10308230), Liang Wang (23021), Xuechun Chang (10308227), Wenyu Li (455531), Chuanzhen Lu (168918), Qinying Li (721250), Qiang Meng (2853221), Hongmei Tan (4533502), Min Wang (21070), Jiahong Lu (4330093), Heng Li (6476), Jian Yu (141239), Juyuan Pan (12324596), Shitao Wu (8769479)   +25 more
core   +1 more source

Aquaporin 4 and its Relationship with Brain Astrocytomas – Literature Review

Brazilian Neurosurgery, 2023
Background Aquaporins (AQPs) are a family of membrane proteins that regulate the osmotic permeability of the plasma membrane. There are described in the literature a total of 13 types of Aquaporins in mammals, each with different places of expression. In
Raphael Vinícius Gonzaga Vieira, Rafaela Farias, Manuela Correa de Toledo Peres, Maria Clara Seba, Paulo Henrique Pires de Aguiar   +4 more
doaj   +1 more source

the-effect-of-the-administration-of-minosycline-n-acetyl-systein-and-its-combinations-on-aquaporin-4-expression-in-the-brain-of-treated-brain-injury-mice-62bd269672899.pdf

, 2023
 Brain injuries are serious health problems and require appropriate management strategies in the healing process. The purpose of this research was to determine the effect of minocycline and single N-Acetylcysteine compared to the administration of a ...
Farhad Balafif (15189535)
core   +1 more source

Data_Sheet_1_Deep learning-based relapse prediction of neuromyelitis optica spectrum disorder with anti-aquaporin-4 antibody.pdf

, 2022
ObjectiveWe previously identified the independent predictors of recurrent relapse in neuromyelitis optica spectrum disorder (NMOSD) with anti-aquaporin-4 antibody (AQP4-ab) and designed a nomogram to estimate the 1- and 2-year relapse-free probability ...
Yuanqi Zhao (677914), Wenjuan Huang (707703), Qiang Dong (380835), Lei Zhou (19808), Junhui Xia (12324599), Jianhua Ma (486317), Lei Du (14992), Bei Wang (116772), Fang Li (41162), Chongbo Zhao (4705297), Chao Quan (449518), Jie Yang (121778), Jingzi ZhangBao (10308230), Liang Wang (23021), Xuechun Chang (10308227), Wenyu Li (455531), Chuanzhen Lu (168918), Qinying Li (721250), Qiang Meng (2853221), Hongmei Tan (4533502), Min Wang (21070), Jiahong Lu (4330093), Heng Li (6476), Jian Yu (141239), Juyuan Pan (12324596), Shitao Wu (8769479)   +25 more
core   +1 more source

Evaluation of aquaporin‐4 antibody assays [PDF]

Clinical and Experimental Neuroimmunology, 2014
AbstractAquaporin‐4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system. In 2005 AQP4 was shown to be the antigenic target of neuromyelitis optica‐immunoglobulin G (NMO‐IgG, or AQP4‐IgG), an antibody found specifically in patients with NMO and in formes frustes of NMO, such as ...
Patrick J, Waters, Sean J, Pittock, Jeffrey L, Bennett, Sven, Jarius, Brian G, Weinshenker, Dean M, Wingerchuk   +5 more
openaire   +2 more sources

Neuromyelitis optica spectrum disorder with increased aquaporin-4 microparticles prior to autoantibodies in cerebrospinal fluid: a case report

Journal of Medical Case Reports, 2019
Background Neuromyelitis optica spectrum disorders are severe autoimmune inflammatory diseases of the central nervous system associated with the presence of immunoglobulin G antibodies against the water channel protein aquaporin-4.
Susanne Bejerot, Eva Hesselmark, Fariborz Mobarrez, Håkan Wallén, Max Albert Hietala, Rolf Nybom, Lennart Wetterberg   +6 more
doaj   +1 more source

Updated diagnostic criteria for neuromyelitis optica spectrum disorder: Similar outcomes of previously separate cohorts

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background The specificity of the aquaporin-4 antibody to predict recurrent inflammatory central nervous system disease has led to the design of the 2015 neuromyelitis optica spectrum disorder criteria which capture all aquaporin-4 antibody seropositive ...
M McCreary, MA Mealy, DM Wingerchuk, M Levy, A DeSena, BM Greenberg   +5 more
doaj   +1 more source

Primary Sjögren’s syndrome related optic neuritis

International Journal of Ophthalmology, 2013
AIM:To determine the clinical features, diagnosis and treatment of the primary Sjögren syndrome (SS) related optic neuritis.METHODS:The clinical data of 8 patients (12 eyes) with primary SS related optic neuritis were analyzed retrospectively.RESULTS ...
Wei-Qiang Tang, Shi-Hui Wei
doaj   +1 more source

Structural basis of aquaporin-4 autoantibody binding in neuromyelitis optica. [PDF]

Sci Adv
Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system where pathogenic autoantibodies target the water channel aquaporin-4 on human astrocytes causing neurological impairment. Autoantibody binding leads to complement-dependent
Gupta M, Khandelwal NK, Nelson A, Hwang P, Pourmal S, Bennett JL, Stroud RM.   +6 more
europepmc   +2 more sources

Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques [PDF]

Journal of Neuropathology & Experimental Neurology, 2020
Abstract Gerstmann-Sträussler-Scheinker (GSS) disease with P102L mutation and familial Creutzfeldt-Jakob disease (CJD) with V180I mutation are 2 major hereditary prion diseases in Japan. GSS and some familial CJD [V180I] exhibit characteristic prion protein (PrP) plaques. Overexpression of the astrocytic water channel proteins aquaporin (
Shoko Sadashima, Hiroyuki Honda, Satoshi O Suzuki, Masahiro Shijo, Shinichi Aishima, Keita Kai, Junichi Kira, Toru Iwaki   +7 more
openaire   +2 more sources