Results 41 to 50 of about 12,794,158 (296)

Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica. [PDF]

, 2011
In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown to be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated T cells in PBMCs during NMO relapses.
Goto, Hirofumi, M. Komori, K.-P. Wandinger, Kondo, Takayuki, K. Nomura, H. Matsuo, Shiraishi, Hirokazu, Wandinger, Klaus-Peter, Matsuo, Hidenori, T. Fukudome, H. Shiraishi, Komori, Mika, Fukudome, Takayasu, S. Nakane, Nakane, Shunya, Nomura, Kyouichi, Matsuya, Nemu, H. Goto, N. Matsuya, T. Kondo   +19 more
core   +1 more source

Image_1_Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.tif

, 2022
BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914), Wenjuan Huang (707703), Qiang Dong (380835), Lei Zhou (19808), Junhui Xia (12324599), Jianhua Ma (486317), Lei Du (14992), Bei Wang (116772), Fang Li (41162), Chongbo Zhao (4705297), Chao Quan (449518), Jie Yang (121778), Jingzi ZhangBao (10308230), Liang Wang (23021), Xuechun Chang (10308227), Wenyu Li (455531), Chuanzhen Lu (168918), Qinying Li (721250), Qiang Meng (2853221), Hongmei Tan (4533502), Min Wang (21070), Jiahong Lu (4330093), Heng Li (6476), Jian Yu (141239), Juyuan Pan (12324596), Shitao Wu (8769479)   +25 more
core   +1 more source

Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl [PDF]

, 2012
It is generally considered that the bladder is impervious and stores urine in unmodified form on account of the barrier imposed by the highly-specialised uro-epithelial lining.
Lisa A Kirkwood, Kirkwood Lisa A., Rubenwolf, Peter C., Jennifer Southgate, Georgopoulos, Nikolaos T., Georgopoulos Nikolaos T., Rubenwolf Peter C., Kirkwood, Lisa A., Baker Simon C., Peter C Rubenwolf, Southgate, Jennifer, Southgate Jennifer, Baker, Simon C., Simon C Baker, Nikolaos T Georgopoulos   +14 more
core   +2 more sources

Table_2_Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.docx

, 2022
BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914), Wenjuan Huang (707703), Qiang Dong (380835), Lei Zhou (19808), Junhui Xia (12324599), Jianhua Ma (486317), Lei Du (14992), Bei Wang (116772), Fang Li (41162), Chongbo Zhao (4705297), Chao Quan (449518), Jie Yang (121778), Jingzi ZhangBao (10308230), Liang Wang (23021), Xuechun Chang (10308227), Wenyu Li (455531), Chuanzhen Lu (168918), Qinying Li (721250), Qiang Meng (2853221), Hongmei Tan (4533502), Min Wang (21070), Jiahong Lu (4330093), Heng Li (6476), Jian Yu (141239), Juyuan Pan (12324596), Shitao Wu (8769479)   +25 more
core   +1 more source

Table_1_Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.docx

, 2022
BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914), Wenjuan Huang (707703), Qiang Dong (380835), Lei Zhou (19808), Junhui Xia (12324599), Jianhua Ma (486317), Lei Du (14992), Bei Wang (116772), Fang Li (41162), Chongbo Zhao (4705297), Chao Quan (449518), Jie Yang (121778), Jingzi ZhangBao (10308230), Liang Wang (23021), Xuechun Chang (10308227), Wenyu Li (455531), Chuanzhen Lu (168918), Qinying Li (721250), Qiang Meng (2853221), Hongmei Tan (4533502), Min Wang (21070), Jiahong Lu (4330093), Heng Li (6476), Jian Yu (141239), Juyuan Pan (12324596), Shitao Wu (8769479)   +25 more
core   +1 more source

Evaluation of aquaporin‐4 antibody assays [PDF]

Clinical and Experimental Neuroimmunology, 2014
AbstractAquaporin‐4 (AQP4) is a water channel protein that is most highly, but not exclusively, expressed in the central nervous system. In 2005 AQP4 was shown to be the antigenic target of neuromyelitis optica‐immunoglobulin G (NMO‐IgG, or AQP4‐IgG), an antibody found specifically in patients with NMO and in formes frustes of NMO, such as ...
Patrick J, Waters, Sean J, Pittock, Jeffrey L, Bennett, Sven, Jarius, Brian G, Weinshenker, Dean M, Wingerchuk   +5 more
openaire   +2 more sources

the-effect-of-the-administration-of-minosycline-n-acetyl-systein-and-its-combinations-on-aquaporin-4-expression-in-the-brain-of-treated-brain-injury-mice-62bd269672899.pdf

, 2023
 Brain injuries are serious health problems and require appropriate management strategies in the healing process. The purpose of this research was to determine the effect of minocycline and single N-Acetylcysteine compared to the administration of a ...
Farhad Balafif (15189535)
core   +1 more source

Neuromyelitis optica spectrum disorder with increased aquaporin-4 microparticles prior to autoantibodies in cerebrospinal fluid: a case report

Journal of Medical Case Reports, 2019
Background Neuromyelitis optica spectrum disorders are severe autoimmune inflammatory diseases of the central nervous system associated with the presence of immunoglobulin G antibodies against the water channel protein aquaporin-4.
Susanne Bejerot, Eva Hesselmark, Fariborz Mobarrez, Håkan Wallén, Max Albert Hietala, Rolf Nybom, Lennart Wetterberg   +6 more
doaj   +1 more source

Primary Sjögren’s syndrome related optic neuritis

International Journal of Ophthalmology, 2013
AIM:To determine the clinical features, diagnosis and treatment of the primary Sjögren syndrome (SS) related optic neuritis.METHODS:The clinical data of 8 patients (12 eyes) with primary SS related optic neuritis were analyzed retrospectively.RESULTS ...
Wei-Qiang Tang, Shi-Hui Wei
doaj   +1 more source

Updated diagnostic criteria for neuromyelitis optica spectrum disorder: Similar outcomes of previously separate cohorts

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2018
Background The specificity of the aquaporin-4 antibody to predict recurrent inflammatory central nervous system disease has led to the design of the 2015 neuromyelitis optica spectrum disorder criteria which capture all aquaporin-4 antibody seropositive ...
M McCreary, MA Mealy, DM Wingerchuk, M Levy, A DeSena, BM Greenberg   +5 more
doaj   +1 more source