Results 61 to 70 of about 85,347,708 (300)

Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy

Frontiers in Cellular Neuroscience, 2022
Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated.
Jenny I. Szu, Devin K. Binder
doaj   +1 more source

Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice [PDF]

Journal of Clinical Investigation, 1999
The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia. To test whether these water channels facilitate fluid movement between airspace, interstitial, and capillary compartments, we measured passive and active fluid transport in AQP1 and AQP4 knockout mice. Airspace-capillary
C, Bai, N, Fukuda, Y, Song, T, Ma, M A, Matthay, A S, Verkman   +5 more
openaire   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Optimization of laboratory diagnostics of neuromyelitis optica spectrum disorders: indications and algorithms [PDF]

Анналы клинической и экспериментальной неврологии
Neuromyelitis optica spectrum disorders are a group of autoimmune demyelinating diseases of the central nervous system characterized by severe exacerbations with development of residual neurological deficit. Anti-aquaporin-4 antibody is one of key factor
Taras O. Simaniv, Vladimir S. Krasnov, Sergey V. Lapin, Raisa T. Bembeeva, Denis S. Korobko, Elena A. Belko, Аlla A. Shabalina   +6 more
doaj   +1 more source

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source

Detection of anti-aquaporin-4 autoantibodies in the sera of Chinese neuromyelitis optica patients.

, 2013
In this study, we recruited 10 neuromyelitis optica patients, two multiple sclerosis patients and two myelitis patients. Chinese hamster lung fibroblast (V79) cells transfected with a human aquaporin-4-mCherry fusion protein gene were used to detect anti-
PISANI, FRANCESCO, FRIGERI, Antonio, Wang J, Li M, Su W, Ma T.   +5 more
core   +1 more source

Combined effects of aquaporin-4 and hypoxia produce age-related hydrocephalus [PDF]

, 2018
Aquaporin-4, present in ependymal cells, in glia limiting and abundantly in pericapillary astrocyte foot pro cesses, and aquaporin-1, expressed in choroid plexus epithelial cells, play an important role in cerebrospinal fluid production and may be ...
Hiraldo González, Laura, Sánchez Gomar, Ismael, Villadiego, Javier, Echevarria, Miriam, Ramirez-Lorca, Reposo, Trillo-Contreras, Jose Luis, Ramírez Lorca, Reposo, Echevarría Irusta, Miriam, Toledo-Aral, Juan Jose, Trillo Contreras, José Luis, Sánchez de Rojas de Pedro, Eva, Galán-Cobo, Ana, Suárez-Luna, Nela, Sanchez-Gomar, Ismael, Toledo Aral, Juan José, Villadiego Luque, Francisco Javier, Hiraldo-Gonzalez, Laura, Sanchez-de-Rojas-de-Pedro, Eva   +17 more
core   +1 more source

Image_1_Neuromyelitis Optica Spectrum Disorder With Anti-Aquaporin-4 Antibody: Outcome Prediction Models.tif

, 2022
BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914), Wenjuan Huang (707703), Qiang Dong (380835), Lei Zhou (19808), Junhui Xia (12324599), Jianhua Ma (486317), Lei Du (14992), Bei Wang (116772), Fang Li (41162), Chongbo Zhao (4705297), Chao Quan (449518), Jie Yang (121778), Jingzi ZhangBao (10308230), Liang Wang (23021), Xuechun Chang (10308227), Wenyu Li (455531), Chuanzhen Lu (168918), Qinying Li (721250), Qiang Meng (2853221), Hongmei Tan (4533502), Min Wang (21070), Jiahong Lu (4330093), Heng Li (6476), Jian Yu (141239), Juyuan Pan (12324596), Shitao Wu (8769479)   +25 more
core   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Alleviation of Cerebral Infarction of Rats With Middle Cerebral Artery Occlusion by Inhibition of Aquaporin 4 in the Supraoptic Nucleus

ASN Neuro, 2020
In ischemic stroke, vasopressin hypersecretion is a critical factor of cerebral swelling and brain injury. To clarify neural mechanisms underlying ischemic stroke-evoked vasopressin hypersecretion, we observed the effect of unilateral permanent middle ...
Dan Cui, Shuwei Jia, Jiawei Yu, Dongyang Li, Tong Li, Yang Liu, Jinlong Chang, Xiaoran Wang, Xiaoyu Liu, Yu-Feng Wang   +9 more
doaj   +1 more source