Results 71 to 80 of about 85,347,708 (300)
Aquaporin 4 expression is downregulated in large bovine ovarian follicles
Journal of Animal Reproduction and Biotechnology, 2020 Aquaporin channels (AQPs) are known to play an important role in the development of ovarian follicles through their function in water transport pathways. Compared to other AQPs, research on the role of AQP4 in female reproductive physiology, particularly
Chang-Woon Kim +5 more
doaj +1 more source
Aquaporin-4 and Parkinson’s Disease
International Journal of Molecular SciencesThe water-selective channel aquaporin-4 (AQP4) is implicated in water homeostasis and the functioning of the glymphatic system, which eliminates various metabolites from the brain tissue, including amyloidogenic proteins. Misfolding of the α-synuclein protein and its post-translational modifications play a crucial role in the development of Parkinson’s
Ksenia V. Lapshina, Irina V. Ekimova
openaire +2 more sources
Physiological Roles of Aquaporin-4 in Brain
Physiological Reviews, 2013 Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While AQP4 has been implicated in a number of pathophysiological processes, its role in brain physiology has remained elusive.
Erlend A, Nagelhus, Ole P, Ottersen
openaire +3 more sources
, 2022 BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914) +25 more
core +1 more source
Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui +10 more
wiley +1 more source
DiagnosticsBackground/Objectives: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-related neurological disease that primarily affects the optic nerve and spinal cord.
Nozomi Yamazaki +3 more
doaj +1 more source
, 2022 BackgroundRecognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy.
Yuanqi Zhao (677914) +25 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu +10 more
wiley +1 more source
Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts
Angewandte Chemie, EarlyView.Low‐concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA‐9 particle size from 657 nm to 260 nm, enhancing endocytosis and photodynamic therapy outcomes.
Sisi Yuan +6 more
wiley +2 more sources
Expression Analysis of Sugarcane Aquaporin Genes under Water Deficit
Journal of Nucleic Acids, 2013 The present work is a pioneer study specifically addressing the aquaporin transcripts in sugarcane transcriptomes. Representatives of the four aquaporin subfamilies (PIP, TIP, SIP, and NIP), already described for higher plants, were identified. Forty-two
Manassés Daniel da Silva +9 more
doaj +1 more source