Results 51 to 60 of about 85,347,708 (300)

Significance of molecular biomarkers in the diagnosis of neuromyelitis optica spectrum disorder [PDF]

Medicinski Podmladak
Discovery of antibodies to aquaporin-4 channels as a laboratory or molecular biomarker for neuromyelitis optica spectrum disorder contributed to a better understanding of the etiopathogenesis, with a clear separation of the clinical, neuroradiological ...
Andabaka Marko, Drulović Jelena, Novaković Ivana   +2 more
doaj   +1 more source

An optimized immunohistochemistry technique improves NMO-IgG detection: study comparison with cell-based assays. [PDF]

PLoS ONE, 2013
Cell-based assays (CBA) have increased the sensitivity of the neuromyelitis optica (NMO)-IgG/aquaporin-4-antibody detection compared to classical tissue-based indirect assays.
Romana Höftberger, Lidia Sabater, Romain Marignier, Fahmy Aboul-Enein, Raphaël Bernard-Valnet, Helmut Rauschka, Anne Ruiz, Yolanda Blanco, Francesc Graus, Josep Dalmau, Albert Saiz   +10 more
doaj   +1 more source

Aquaporin-4 Autoantibodies in a Paraneoplastic Context [PDF]

Archives of Neurology, 2008
The neuromyelitis optica IgG autoantibody (NMO-IgG) is a validated biomarker for NMO and an emerging spectrum of inflammatory central nervous system-demyelinating disorders. Its antigen is the astrocytic water channel aquaporin-4; NMO-IgG has not been described in a cancer context.To report (1) neurologic and oncologic correlates for patients ...
Sean J, Pittock, Vanda A, Lennon
openaire   +2 more sources

Increased T-cell immunity against aquaporin-4 and proteolipid protein in neuromyelitis optica. [PDF]

, 2011
In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown to be essential. However, the role of T cells remains ambiguous. Here, we first showed an increase in CD69+ activated T cells in PBMCs during NMO relapses.
Goto, Hirofumi, M. Komori, K.-P. Wandinger, Kondo, Takayuki, K. Nomura, H. Matsuo, Shiraishi, Hirokazu, Wandinger, Klaus-Peter, Matsuo, Hidenori, T. Fukudome, H. Shiraishi, Komori, Mika, Fukudome, Takayasu, S. Nakane, Nakane, Shunya, Nomura, Kyouichi, Matsuya, Nemu, H. Goto, N. Matsuya, T. Kondo   +19 more
core   +1 more source

The mechanisms underlying the actions of Xuefu Zhuyu decoction pretreatment against neurological deficits after ischemic stroke in mice: The mediation of glymphatic function by aquaporin-4 and its anchoring proteins

Frontiers in Pharmacology, 2022
Ischemic stroke (IS) has been associated with an impairment in glymphatic function. Xuefu Zhuyu Decoction (XFZYD) is widely used in the prevention and treatment of ischemic stroke.
Ting Yi, Ping Gao, Meng Hou, Huan Lv, Mengyuan Huang, Shanshan Gao, Jinrong He, Dongdong Yang, Weiyin Chen, Tianmin Zhu, Chang Yu, Fuyou Liu, Haiyan Yin, Shuoguo Jin   +13 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Impact of the anti-aquaporin-4 autoantibody on inner retinal structure, function and structure-function associations in Japanese patients with optic neuritis - Fig 1

, 2017
Representative cases of aquaporin-4 antibody (AQP4 Ab)-positive (A−C) and -negative (D−F) optic neuritis in the left eye. Shown are optic nerve head maps (A, D) and GCC significance maps (B, E) from RTVue optical coherence tomography analyses, and gray ...
Sotaro Mori (3749752), Yoshiko Matsumoto (3749764), Takuji Kurimoto (3749761), Akiyasu Kanamori (3749749), Makoto Nakamura (199152), Yuko Yamada (3749758), Ichiro Nakashima (3574049), Kaori Ueda (3749755)   +7 more
core   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

PENGARUH BISAKODIL TERHADAP EKSPRESI TRANSPORTER AQUAPORIN-3, AQUAPORIN-4 DAN PPARγ PADA KONSTIPASI YANG DIINDUKSI MORFIN [PDF]

, 2019
Morphine is an opioid analgesic used to treat acute pain and chronic pain. Morphine can cause constipation due to the effect on the enteric nervous system and increased level of aquaporin transporter expression in colon. The administration of morphine is
PUJI LISTIANA RAHAYU, 051511133171
core   +1 more source