Results 41 to 50 of about 38,738 (164)
Mechanisms Underlying Aquaporin-4 Subcellular Mislocalization in Epilepsy
Frontiers in Cellular Neuroscience, 2022 Epilepsy is a chronic brain disorder characterized by unprovoked seizures. Mechanisms underlying seizure activity have been intensely investigated.
Jenny I. Szu, Devin K. Binder
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H95 Is a pH-Dependent Gate in Aquaporin 4 [PDF]
Structure, 2015 Aquaporin 4 (AQP4) is a transmembrane protein from the aquaporin family and is the predominant water channel in the mammalian brain. The regulation of permeability of this protein could be of potential therapeutic use to treat various forms of damage to the nervous tissue.
Kaptan, Shreyas +6 more
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Structural Determinants of Oligomerization of the Aquaporin-4 Channel [PDF]
Journal of Biological Chemistry, 2016 The aquaporin (AQP) family of integral membrane protein channels mediate cellular water and solute flow. Although qualitative and quantitative differences in channel permeability, selectivity, subcellular localization, and trafficking responses have been observed for different members of the AQP family, the signature homotetrameric quaternary structure
Kitchen +4 more
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Optimization of laboratory diagnostics of neuromyelitis optica spectrum disorders: indications and algorithms [PDF]
Анналы клинической и экспериментальной неврологииNeuromyelitis optica spectrum disorders are a group of autoimmune demyelinating diseases of the central nervous system characterized by severe exacerbations with development of residual neurological deficit. Anti-aquaporin-4 antibody is one of key factor
Taras O. Simaniv +6 more
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Glymphatic system and aquaporin‑4 in epilepsy
Acta Neurobiologiae Experimentalis, 2023 Over the past decade glymphatic concept has gained more and more interest. Despite some lacking data regarding structural and functional aspects, glymphatic system is widely considered the main mechanism of water and solutes transport in brain parenchyma, as well as waste clearance from the brain.
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Aquaporin‐4 Overexpression in Rat ALS Model [PDF]
The Anatomical Record, 2008 AbstractOnset of motoneuron death characterizing amyotrophic lateral sclerosis (ALS) is closely linked to modified astrocytic and glial environments. Here, we show that in the spinal cord from transgenic rat overexpressing mutated human SOD1, aquaporin‐4 mRNA and protein are specifically overexpressed in the gray matter at end stage of disease ...
Nicaise, Charles +6 more
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Aquaporin 4 expression is downregulated in large bovine ovarian follicles
Journal of Animal Reproduction and Biotechnology, 2020 Aquaporin channels (AQPs) are known to play an important role in the development of ovarian follicles through their function in water transport pathways. Compared to other AQPs, research on the role of AQP4 in female reproductive physiology, particularly
Chang-Woon Kim +5 more
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ASN Neuro, 2020 In ischemic stroke, vasopressin hypersecretion is a critical factor of cerebral swelling and brain injury. To clarify neural mechanisms underlying ischemic stroke-evoked vasopressin hypersecretion, we observed the effect of unilateral permanent middle ...
Dan Cui +9 more
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DiagnosticsBackground/Objectives: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-related neurological disease that primarily affects the optic nerve and spinal cord.
Nozomi Yamazaki +3 more
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Expression Analysis of Sugarcane Aquaporin Genes under Water Deficit
Journal of Nucleic Acids, 2013 The present work is a pioneer study specifically addressing the aquaporin transcripts in sugarcane transcriptomes. Representatives of the four aquaporin subfamilies (PIP, TIP, SIP, and NIP), already described for higher plants, were identified. Forty-two
Manassés Daniel da Silva +9 more
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