Results 41 to 50 of about 26,122,743 (292)
Aquaporin-4 Polymorphisms Are Associated With Cognitive Performance in Parkinson’s Disease
Frontiers in Aging Neuroscience, 2022 Objective Aquaporin-4 (AQP4) facilitates a sleep-enhanced interstitial brain waste clearance system. This study was conducted to determine the clinical implication of AQP4 polymorphisms in Parkinson’s disease (PD).
Yi Fang +11 more
semanticscholar +1 more source
Rinsho Shinkeigaku, 2008 In human body, there are thirteen water channels but their expression patterns are tissue specific. Aquaporin-4 (AQP4) is a predominantly expressed water channel in the mammalian brain and an important drug target for treatment of cerebral edema, bipolar disorder, and mesial temporal lobe epilepsy.
Tani, Kazutoshi +2 more
openaire +3 more sources
The Role of Aquaporins in Spinal Cord Injury
Cells, 2023 Edema formation following traumatic spinal cord injury (SCI) exacerbates secondary injury, and the severity of edema correlates with worse neurological outcome in human patients. To date, there are no effective treatments to directly resolve edema within
Terese A. Garcia +2 more
doaj +1 more source
Long‐Term Safety and Efficacy of Eculizumab in Aquaporin‐4 IgG‐Positive NMOSD
Annals of Neurology, 2021 During PREVENT (NCT01892345), eculizumab significantly reduced relapse risk versus placebo in patients with aquaporin‐4 immunoglobulin G‐positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD). We report an interim analysis of PREVENT's ongoing
D. Wingerchuk +13 more
semanticscholar +1 more source
Aquaporin-4 expression in the human choroid plexus [PDF]
Cellular and Molecular Life Sciences, 2021 Abstract The choroid plexus (CP) consists of specialized ependymal cells and underlying blood vessels and stroma producing the bulk of the cerebrospinal fluid (CSF). CP epithelial cells are considered the site of the internal blood-cerebrospinal fluid barrier, show epithelial characteristics (basal lamina, tight junctions), and ...
Felix Deffner +7 more
openaire +3 more sources
Preparative scale production of functional mouse aquaporin 4 using different cell-free expression modes [PDF]
, 2010 The continuous progress in the structural and functional characterization of aquaporins increasingly attracts attention to study their roles in certain mammalian diseases.
Volker Dötsch +23 more
core +2 more sources
Isolated dysphagia due to aquaporin-4 autoimmunity
The Turkish Journal of Gastroenterology, 2012 İstanbul Bilim Üniversitesi, Tıp Fakültesi.Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease that affects the spinal cord and optic nerves and is associated with aquaporin- 4 antibodies (Aqp-4 Ab).
Editorial Office
doaj +2 more sources
Multiple Sclerosis, 2021 Background: Efficacy and safety of inebilizumab for treatment of neuromyelitis optica spectrum disorder in adults seropositive for aquaporin-4 (AQP4)–immunoglobulin (Ig) G were demonstrated in the 28-week randomized controlled period of the N-MOmentum ...
M. Rensel +6 more
semanticscholar +1 more source
Aquaporin 4 is a ubiquitously expressed isoform in the dogfish (Squalus acanthias) shark [PDF]
, 2012 Christopher P.Cutler is in receipt of a grant from the National Science Foundation, NSFIOS0844818.The dogfish ortholog of aquaporin 4 (AQP4) was amplified from cDNA using degenerate PCR followed by cloning and sequencing.
MacIver, Bryce +15 more
core +1 more source
Bisacodyl overcomes morphine-induced constipation by decreasing colonic Aquaporin-3 and Aquaporin-4 expression [PDF]
Research Results in Pharmacology, 2022 Introduction: Morphine is an opioid prescribed to treat aches and pains. However, morphine often causes opioid-induced constipation (OIC). Aquaporin (AQP) transporters, especially AQP3 and AQP4, play an essential role in mediating constipation. Bisacodyl
Mahardian Rahmadi +9 more
doaj +3 more sources