Results 1 to 10 of about 18,179 (218)
Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms
Cells, 2020 The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.
Shirin Katoozi +2 more
exaly +3 more sources
AQP1 and AQP4 Contribution to Cerebrospinal Fluid Homeostasis [PDF]
Cells, 2019 Aquaporin 1 (AQP1), expressed in epithelial cells of the choroid plexus, and aquaporin 4 (AQP4) present in ependymal cells and glia limitants have been proposed to play a significant role in cerebrospinal fluid (CSF) production and homeostasis. However, the specific contribution of each water channel to these functions remains unknown, being a subject ...
José Luis Trillo-Contreras +2 more
exaly +8 more sources
Deletional tolerance prevents AQP4‐directed autoimmunity in mice [PDF]
European Journal of Immunology, 2017 Neuromyelitis optica (NMO) is an autoimmune disorder of the central nervous system (CNS) mediated by antibodies to the water channel protein AQP4 expressed in astrocytes. The contribution of AQP4‐specific T cells to the class switch recombination of pathogenic AQP4‐specific antibodies and the inflammation of the blood–brain barrier is incompletely ...
Benjamin Knier +2 more
exaly +3 more sources
Key astroglial markers in human liver cirrhosis of different degree: immunohistochemical study
Zaporožskij Medicinskij Žurnal, 2022 The aim of the study – determining the immunohistochemical levels of the GFAP, GS and AQP4 in different regions of the human brain in the conditions of liver cirrhosis of different degree. Materials and methods.
T. V. Shulyatnikova, V. O. Tumanskyi
doaj +1 more source
Archives of Epilepsy, 2022 Objective: Aquaporin4 is the main water channel in the brain that is associated with neurological disorders. The role and the expressive changes of aquaporin4 in epilepsy are still limited and controversial. The study aims to evaluate the expression of c-
Emine Taşkıran +7 more
doaj +1 more source
Patologìâ, 2023 The aim of the study. Immunohistochemical study of Nestin, CD44, Ki-67, GS, AQP4 expression in the subventricular zone of the lateral ventricle and hippocampus of deceased patients with liver cirrhosis depending on the age and Child–Pugh score ...
T. V. Shulyatnikova, V. O. Tumanskiy
doaj +1 more source
Общая реаниматология, 2023 Aquaporins 4 and 5 are proteins that form water channels in the cell membrane, participate in the transfer and migration of immune cells, being expressed on many cell types including CNS astrocytes, kidney cells, lungs, and the immune system.
A. G. Chumachenko +4 more
doaj +1 more source
Regulation of AQP4 in the Central Nervous System [PDF]
International Journal of Molecular Sciences, 2020 Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in CNS water and potassium homeostasis. Changes in AQP4 activity and expression have been implicated in several CNS disorders, including (but not limited to) epilepsy, edema ...
Vandebroek, Arno, Yasui, Masato
openaire +2 more sources
Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica. [PDF]
PLoS ONE, 2011 BACKGROUND: Antibodies to the water channel protein aquaporin-4 (AQP4), which is expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum of Neuromyelitis optica (NMO) patients and are believed to induce damage to ...
Sudhakar Reddy Kalluri +7 more
doaj +1 more source
Open Medicine, 2023 This study aimed to investigate the effect of aquaporin-4 (AQP4) on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts.
Fan Yong +5 more
doaj +1 more source