Results 1 to 10 of about 18,333 (223)

Neuromyelitis Optica-AQP4: An Update

Current Rheumatology Reports, 2011
Devic disease (neuromyelitis optica [NMO]) is an idiopathic inflammatory demyelinating and necrotizing disease characterized by optic neuritis and transverse myelitis, either simultaneously or in isolation. NMO is often idiopathic but may also be associated with systemic autoimmune disease. The prognosis of NMO is severe, especially in those with early
Emilio, Benavente, Sergio, Paira
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Abstract P1-10-09: AQP4 inhibition prevents cytotoxic edema of AQP4+ astrocytes but promotes tumor growth of AQP4+ breast cancer brain metastasis

Cancer Research, 2023
Abstract Brain edema is a complication of radiation used to treat brain metastasis (BM) in which the brain parenchyma accumulates fluid and ions, often leading to the suspension of systemic anticancer treatment. While brain edema is often attributed to disruption of the Blood Brain Barrier (BBB), RTx induces cytotoxic-edema, a premorbid ...
Maria J. Contreras-Zarate, Karen ALvarez-Eraso, Nicole Tsuji, Peter Kabos, D.Ryan Ormond, Sana Karam, Diana Cittelly   +6 more
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Chimeric AQP4-based immunosorbent for highly-specific removal of AQP4-IgG from blood

Journal of Chromatography A
Anti-aquaporin-4 autoantibodies (AQP4-IgG) are implicated in the pathogenesis of neuromyelitis optica spectrum disorders (NMOSD), and their removal from the blood circulation is considered to be an effective method for acute treatment. An ideal extracorporeal AQP4-IgG removal system should have high specificity, which means that it can selectively ...
Xiaofei Wang, Fangling Ji, Lingyun Jia
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Expression of AQP1 and AQP4 in paediatric brain tumours

Journal of Clinical Neuroscience, 2011
Aquaporins (AQP) are water-channel proteins with roles in tumour cell migration, angiogenesis, cerebral oedema and cell-cell adhesion. We aimed to determine the expression of AQP1 and AQP4 in paediatric brain tumours. Twenty tumour bank specimens were subject to Western blot analysis and quantitative polymerase chain reaction (PCR) to determine the ...
Dongwei, Wang, Brian K, Owler
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Regulation and Function of AQP4 in the Central Nervous System

Neurochemical Research, 2015
Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation.
Assentoft, Mette, Larsen, Brian Roland, MacAulay, Nanna   +2 more
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Abnormalities in the pattern of AQP4 immunoreactivity

The FASEB Journal, 2006
With regard to the paper by Meshorer et al. (1), the authors address an interesting question concerning long-lasting consequences of cholinergic imbalance. To address this question, the authors used transgenic mice (TgS) with a neuronal overexpression of synaptic acetylcholinesterase, in which they observed a significant decrease in the baseline of the
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Mechanisms underlying AQP4 accumulation in astrocyte endfeet

Glia, 2015
The brain–blood interface holds the key to our understanding of how cerebral blood flow is regulated and how water and solutes are exchanged between blood and brain. The highly specialized astrocytic membranes that enwrap brain microvessels are salient constituents of the brain‐blood interface.
Laura Maria Azzurra, Camassa, Lisa K, Lunde, Eystein H, Hoddevik, Maria, Stensland, Henning B, Boldt, Gustavo A, De Souza, Ole P, Ottersen, Mahmood, Amiry-Moghaddam   +7 more
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Comparative analysis of AQP4-IgG-positive and AQP4-IgG-negative NMOSD: A multicenter study in Latin America

Multiple Sclerosis and Related Disorders
NMOSD is a rare autoimmune disorder with variable clinical presentations depending on AQP4-IgG serostatus. While AQP4-IgG-positive NMOSD is well described, data on seronegative cases, especially in Latin America, remain limited.To characterize the demographic and clinical features of NMOSD in Latin America, comparing AQP4-IgG-positive and AQP4-IgG ...
Ricardo Alonso, Carlos Navas, María Eugenia Balbuena, Nora Aurora Rosa Fernández Liguori, Saúl Reyes, Enrique Gómez Figueroa, Edgar Carnero Carnero Contentti, Ibis Soto, Luis Zarco, José de Jesús Flores Rivera, María Isabel Zuluaga Rodas, Nayeli A. Sánchez Rosales, Jefferson Becker, Irene Treviño Frenk, Ethel Ciampi, Edgar Patricio Correa Díaz, Fernando Gracia, César Franco, Carolina Restrepo-Aristizábal, Valeria Uribe-Vizcarra, José Alejandro Ramírez, Santiago Andrés Vintimilla Pesantez, Jordi García Acosta, David Giraldo, Sandra Mendoza de Salazar, Cecilia González, Jazmín Márquez-Pedroza, Jaime Toro, Juan Pablo Noriega, Natali Guerrero-Udave, Andrea Chaves, Estefanía Sánchez Uribe, Juan Pablo Londoño Aristizábal, Lorna Galleguillos   +33 more
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AQP4 antibody serostatus

Neurology, 2013
Detecting aquaporin-4 (AQP4) antibody is a key laboratory finding in the diagnosis of neuromyelitis optica (NMO) or its limited forms, known as NMO spectrum disorders (NMOSD).1,2 It is important to differentiate NMO from multiple sclerosis (MS), as drugs approved for MS (interferon-β, natalizumab, and fingolimod) are ineffective in NMO/NMOSD.
Kazuo, Fujihara, Douglas Kazutoshi, Sato
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AQP4-DARPin1: A Chimeric Antigen Based on Scaffold Protein DARPin for Efficient Detection of AQP4-IgG in NMOSD

Biochemistry
AQP4-IgG is an autoantibody associated with neuromyelitis optica spectroscopic disorder (NMOSD), a central nervous system inflammatory disease that requires early diagnosis and treatment. We designed two fusion proteins, AQP4-DARPin1 and AQP4-DARPin2, comprising the complete antigenic epitopes of aquaporin-4 (AQP4) and the constant region of the ...
Xiaofei Wang, Shubei Ma, Ying Bai, Xinyang Wu, Fangling Ji, Lingyun Jia   +5 more
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