Results 1 to 10 of about 23,657 (257)

Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms [PDF]

Cells, 2020
The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.
Shirin Katoozi, Nadia Skauli, Soulmaz Zahl, Tushar Deshpande, Pascal Ezan, Claudia Palazzo, Christian Steinhäuser, Antonio Frigeri, Martine Cohen-Salmon, Ole Petter Ottersen, Mahmood Amiry-Moghaddam   +10 more
doaj   +2 more sources

Key astroglial markers in human liver cirrhosis of different degree: immunohistochemical study

Zaporožskij Medicinskij Žurnal, 2022
The aim of the study – determining the immunohistochemical levels of the GFAP, GS and AQP4 in different regions of the human brain in the conditions of liver cirrhosis of different degree. Materials and methods.
T. V. Shulyatnikova, V. O. Tumanskyi
doaj   +1 more source

Nestin, CD44, Ki-67, GS and AQP4 expression in the brain neurogenic niches of deceased patients with liver cirrhosis of different degree

Patologìâ, 2023
The aim of the study. Immunohistochemical study of Nestin, CD44, Ki-67, GS, AQP4 expression in the subventricular zone of the lateral ventricle and hippocampus of deceased patients with liver cirrhosis depending on the age and Child–Pugh score ...
T. V. Shulyatnikova, V. O. Tumanskiy
doaj   +1 more source

Changes in the Expression of c-fos and AQP4 in the Hippocampus and Amygdala Regions of Rats with Kainic Acid-Induced Temporal Lobe Epilepsy and Their Role in the Pathogenesis of Disease

Archives of Epilepsy, 2022
Objective: Aquaporin4 is the main water channel in the brain that is associated with neurological disorders. The role and the expressive changes of aquaporin4 in epilepsy are still limited and controversial. The study aims to evaluate the expression of c-
Emine Taşkıran, Canan Uğur Yılmaz, Nurcan Orhan, Mehmet Kaya, Nadir Arican, Metin Berkant Bahçeci, Bülent Ahishali, Candan Gürses   +7 more
doaj   +1 more source

Sepsis Course and Outcome Depends on the Genetic Variant in the 3`-Region of Aquaporin 4 Gene AQP4 and Comorbidities

Общая реаниматология, 2023
Aquaporins 4 and 5 are proteins that form water channels in the cell membrane, participate in the transfer and migration of immune cells, being expressed on many cell types including CNS astrocytes, kidney cells, lungs, and the immune system.
A. G. Chumachenko, E. K. Grigoriev, R. A. Cherpakov, I. N. Tyurin, V. M. Pisarev   +4 more
doaj   +1 more source

The effect of AQP4 on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts

Open Medicine, 2023
This study aimed to investigate the effect of aquaporin-4 (AQP4) on tau protein aggregation in neurodegeneration and persistent neuroinflammation after cerebral microinfarcts.
Fan Yong, Yang Yongkai, Lin Kunzhe, Zhou Xiaohui, Li Yongkun, Lin Qingqiang   +5 more
doaj   +1 more source

Late-Onset Neuromyelitis Optica Spectrum Disorder Mimicking a Non-Arteritic Anterior Ischemic Optic Neuropathy–Case Report

Türk Oftalmoloji Dergisi, 2023
A 60-year-old white woman presented to the emergency department with painless decrease of visual acuity in the left eye (LE). The diagnosis of a non-arteritic anterior ischemic optic neuropathy in the LE was established based on the clinical picture and ...
Lech Sedlak, Marta Swierczynska, Dorota Wygledowska Promienska   +2 more
doaj   +1 more source

Functional characterization of aquaporin-4 specific T cells: towards a model for neuromyelitis optica. [PDF]

PLoS ONE, 2011
BACKGROUND: Antibodies to the water channel protein aquaporin-4 (AQP4), which is expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum of Neuromyelitis optica (NMO) patients and are believed to induce damage to ...
Sudhakar Reddy Kalluri, Veit Rothhammer, Ori Staszewski, Rajneesh Srivastava, Franziska Petermann, Marco Prinz, Bernhard Hemmer, Thomas Korn   +7 more
doaj   +1 more source

Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder

Scientific Reports, 2021
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system. Most NMOSD patients are seropositive for immunoglobulin G (IgG) autoantibodies against astrocyte water channel aquaporin-4 (AQP4), called ...
Lukmanee Tradtrantip, Michael R. Yeaman, A. S. Verkman   +2 more
doaj   +1 more source

Protection of Vascular Endothelial Growth Factor to Brain Edema Following Intracerebral Hemorrhage and Its Involved Mechanisms: Effect of Aquaporin-4. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor (VEGF) has protective effects on many neurological diseases. However, whether VEGF acts on brain edema following intracerebral hemorrhage (ICH) is largely unknown.
Heling Chu, Yuping Tang, Qiang Dong
doaj   +1 more source