Results 41 to 50 of about 18,179 (218)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Aquaporin-4 Autoantibodies From Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice

Frontiers in Immunology, 2018
Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders causing significant morbidities and mortality. The majority of NMOSD patients have autoimmunity against aquaporin-4 (AQP4), evidenced by seropositivity for ...
Leung-Wah Yick, Leung-Wah Yick, Oscar Ka-Fai Ma, Oscar Ka-Fai Ma, Roy Chun-Laam Ng, Roy Chun-Laam Ng, Jason Shing-Cheong Kwan, Jason Shing-Cheong Kwan, Koon-Ho Chan, Koon-Ho Chan   +9 more
doaj   +1 more source

Aquaporin4 (AQP4) in brain disorder

Folia Pharmacologica Japonica, 2019
Two third of our body is composed of water molecules. Regulation of water and electrolytes is indeed the most important homeostatic functions. Many diseases, such as heart failure, are associated with disturbance in fluid homeostasis. Surprisingly, water dynamics inside the brain is still largely unknown.
openaire   +3 more sources

Nitric oxide conduction by the brain aquaporin AQP4 [PDF]

Proteins: Structure, Function, and Bioinformatics, 2009
AbstractInvolvement of aquaporins in gas conduction across the membrane and the physiological significance of this process have attracted marked attention from both experimental and theoretical studies. Previous work demonstrated that AQP1 is permeable to both CO2 and O2.
Yi, Wang, Emad, Tajkhorshid
openaire   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Changes in AQP4 expression and the pathology of injured cultured astrocytes after AQP4 mRNA silencing

Neuropsychiatry, 2018
Objectives: In this study, we investigated AQP4 expression in injured astrocytes in vitro, as well as the influence of AQP4 levels on pathology using gene silencing. Methods: Astrocytes were cultured and the mechanical scratch method was used to simulate an injury.
Jianqiang Chen, Qingjie Xia, Hong Lu
openaire   +1 more source

The Structure of AQP4 and Its Relationship to Disease

The FASEB Journal, 2021
Aquaporin‐4 (AQP4) is the most common water channel protein in the central nervous system (Flippidis, Carozza, & Rekate, 2016). It is highly concentrated in the cell membrane of the astrocytic endfeet, which form the blood‐brain barrier (BBB) and help protect the brain from toxins (Mader & Brimberg, 2019; Woodruff & Götz, 2018).
Koyuki Yamada, Ishani Pidara
openaire   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

AQP4 knockout promotes neurite outgrowth via upregulating GAP43 expression in infant rats with hypoxic‐ischemic brain injury

Ibrain, 2022
Neonatal hypoxic‐ischemic encephalopathy (NHIE) induces severe cerebral damage and neurological dysfunction, with seldom effective therapy. Aquaporin‐4 (AQP4) is involved in aggravating brain damage induced by NHIE.
Qi‐Qin Dan, Zheng Ma, Ya‐Xin Tan, Belegu Visar, Li Chen   +4 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source