Results 41 to 50 of about 24,501 (255)
direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate [PDF]
, 2014 Background Neuromyelitis optica (NMO, Devic syndrome) is associated with antibodies to aquaporin-4 (NMO-IgG/AQP4-Ab) in the majority of cases. NMO- IgG/AQP4-Ab seropositivity in patients with NMO and its spectrum disorders has important differential ...
Jarius, Sven +9 more
core +1 more source
Frontiers in Physiology, 2012 The role of aquaporin water channels in Elasmobanchs such as the dogfish Squalus acanthias is completely unknown. This investigation determines the expression and cellular and sub-cellular localization of AQP4 protein in dogfish tissues.
Christopher P Cutler +7 more
doaj +1 more source
Müller cell markers in aqueous humor of patients with type-2 macular telangiectasia
Indian Journal of OphthalmologyPurpose: To investigate the pathogenesis of type-2 macular telangiectasia (MacTel) by comparing the levels of glial fibrillary acidic protein (GFAP), aquaporin-4 (AQP4), and K+ inwardly rectifying channel 4.1 (Kir4.1) in the aqueous humor of diagnosed ...
Elçin Osmanlı +4 more
doaj +1 more source
Aquaporin 4 expression is downregulated in large bovine ovarian follicles
Journal of Animal Reproduction and Biotechnology, 2020 Aquaporin channels (AQPs) are known to play an important role in the development of ovarian follicles through their function in water transport pathways. Compared to other AQPs, research on the role of AQP4 in female reproductive physiology, particularly
Chang-Woon Kim +5 more
doaj +1 more source
The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory
Frontiers in Integrative Neuroscience, 2016 Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system. AQP4 is widely expressed throughout the brain, especially at the blood-brain barrier where AQP4 is highly polarized to astrocytic foot processes ...
Jenny I. Szu, Devin K. Binder
doaj +1 more source
Correlations of AQP4 expression and polymorphism with diabetic retinopathy.
European review for medical and pharmacological sciences, 2021 The aim of this study was to investigate the relationships of aquaporin 4 (AQP4) rs200498749, rs149465 and rs650217 polymorphisms and gene expression with diabetic retinopathy (DR).A total of 400 patients with diabetes mellitus (DM) treated in our hospital were enrolled in this study. All subjects were divided into two groups, including DM group (n=200,
Zhou, X., Cheng, F.-C., Wang, H.-L.
openaire +2 more sources
, 2015 (A) Analysis of AQP4 IgG binding on E21 (M23 enriched fraction), E27 (M1 enriched fraction) and total extract using a pool of High (H) and of Low (L) titer sera each from five different NMO patients.
Maddalena Ruggieri (485748) +10 more
core +1 more source
Toward New AQP4 Inhibitors: ORI-TRN-002
International Journal of Molecular Sciences, 2023 Cerebral edema is a life-threatening condition that can cause permanent brain damage or death if left untreated. Existing therapies aim at mitigating the associated elevated intracranial pressure, yet they primarily alleviate pressure rather than prevent edema formation. Prophylactic anti-edema therapy necessitates novel drugs targeting edema formation.
Michael Thormann +6 more
openaire +3 more sources
AQP4 autoantibodies in patients with idiopathic normal pressure hydrocephalus
, 2020 Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder with unknown etiology. A selective depletion of aquaporin 4 (AQP4) has been shown in iNPH patients.
Claudio P. +23 more
core +1 more source
T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity
, 2023 Aquaporin-4 (AQP4)-specific Th17 cells are thought to have a central role in neuromyelitis optica (NMO) pathogenesis. When modeling NMO, only AQP4-reactive Th17 cells from AQP4-deficient (AQP4-/-), but not wild-type (WT) mice, caused CNS autoimmunity in ...
Carson E. Moseley +29 more
core +1 more source