Results 51 to 60 of about 24,501 (255)

Aquaporin-4 Expression during Toxic and Autoimmune Demyelination

Cells, 2020
The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood–brain interface. Following the discovery that AQP4 is a possible autoantigen in neuromyelitis optica, the function of AQP4 in health and disease
Sven Olaf Rohr, Theresa Greiner, Sarah Joost, Sandra Amor, Paul van der Valk, Christoph Schmitz, Markus Kipp   +6 more
doaj   +1 more source

Hypothalamic Neurochemical and Microglial Suppression in Long-Standing Human Hibernation-Like Syndrome. [PDF]

Neuropathol Appl Neurobiol
A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Jiang W, Kalsbeek A, Hut RA, Swaab DF, Yi CX.   +4 more
europepmc   +2 more sources

Nitric oxide conduction by the brain aquaporin AQP4 [PDF]

Proteins: Structure, Function, and Bioinformatics, 2009
AbstractInvolvement of aquaporins in gas conduction across the membrane and the physiological significance of this process have attracted marked attention from both experimental and theoretical studies. Previous work demonstrated that AQP1 is permeable to both CO2 and O2.
Yi, Wang, Emad, Tajkhorshid
openaire   +2 more sources

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Changes in AQP4 expression and the pathology of injured cultured astrocytes after AQP4 mRNA silencing

Neuropsychiatry, 2018
Objectives: In this study, we investigated AQP4 expression in injured astrocytes in vitro, as well as the influence of AQP4 levels on pathology using gene silencing. Methods: Astrocytes were cultured and the mechanical scratch method was used to simulate an injury.
Jianqiang Chen, Qingjie Xia, Hong Lu
openaire   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Immunoreactivity against AQP4 (red) and GFAP (green).

, 2013
(A) In human glioblastoma tissue AQP4 (red) shows an intensive staining whereas in primary cell culture of this glioblastoma AQP4 could not be detected (B). (C) Primary cell culture of astrocytes stained for AQP4.
Karen Wolburg-Buchholz (323517), Susan Noell (294230), Hartwig Wolburg (185538), Petra Fallier-Becker (323518), Rainer Ritz (294227)   +4 more
core   +1 more source

Aquaporin-4 Autoantibodies From Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice

Frontiers in Immunology, 2018
Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders causing significant morbidities and mortality. The majority of NMOSD patients have autoimmunity against aquaporin-4 (AQP4), evidenced by seropositivity for ...
Leung-Wah Yick, Leung-Wah Yick, Oscar Ka-Fai Ma, Oscar Ka-Fai Ma, Roy Chun-Laam Ng, Roy Chun-Laam Ng, Jason Shing-Cheong Kwan, Jason Shing-Cheong Kwan, Koon-Ho Chan, Koon-Ho Chan   +9 more
doaj   +1 more source

Aquaporin4 (AQP4) in brain disorder

Folia Pharmacologica Japonica, 2019
Two third of our body is composed of water molecules. Regulation of water and electrolytes is indeed the most important homeostatic functions. Many diseases, such as heart failure, are associated with disturbance in fluid homeostasis. Surprisingly, water dynamics inside the brain is still largely unknown.
openaire   +3 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source