Results 51 to 60 of about 18,179 (218)

Effects of AQP4 and KCNJ10 Gene Polymorphisms on Drug Resistance and Seizure Susceptibility in Chinese Han Patients with Focal Epilepsy

Neuropsychiatric Disease and Treatment, 2020
Haoyue Zhu, Mengqi Zhang, Yujiao Fu, Hongyu Long, Wenbiao Xiao, Li Feng, Bo Xiao, Luo Zhou Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Luo ZhouDepartment of ...
Zhu H, Zhang M, Fu Y, Long H, Xiao W, Feng L, Xiao B, Zhou L   +7 more
doaj  

Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

Journal of Neuroinflammation, 2010
Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
Jarius Sven, Franciotta Diego, Paul Friedemann, Ruprecht Klemens, Bergamaschi Roberto, Rommer Paulus S, Reuss Reinhard, Probst Christian, Kristoferitsch Wolfgang, Wandinger Klaus, Wildemann Brigitte   +10 more
doaj   +1 more source

The effect of aquaporin-4 mis-localization on Aβ deposition in mice

Neurobiology of Disease, 2023
The reduced clearance of amyloid-β (Aβ) is thought to contribute to the development of the pathology associated with Alzheimer's disease (AD), which is characterized by the deposition of Aβ plaques.
Taylor J. Pedersen, Samantha A. Keil, Warren Han, Marie X. Wang, Jeffrey J. Iliff   +4 more
doaj   +1 more source

Reactivity to AQP4 epitopes in relapsing–remitting multiple sclerosis [PDF]

Journal of Neuroimmunology, 2013
Autoantibodies against the water channel AQP4, expressed predominately in central nervous system astrocytes, are markers and pathogenic factors in Devic's disease. In this study we examined whether Multiple Sclerosis (MS) patients recognize antigenic epitopes on AQP4 that may define distinct disease subsets.
Alexopoulos, H., Kampylafka, E. I., Chatzi, I., Travasarou, M., Karageorgiou, K. E., Dalakas, M. C., Tzioufas, A. G.   +6 more
openaire   +4 more sources

Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock, Jin Nakahara, Becky Parks, Kerstin Allen, Sami Fam   +4 more
wiley   +1 more source

Aquaporin-4 deficiency induced white matter injury via upregulated complement component 3 in cerebral small vessel disease

Journal of Neuroinflammation
Background Cerebral small vessel disease (CSVD) is the most common neurological disorder associated with a high incidence of stroke and dementia. For the heterogeneity of the pathogenesis, effective preventive and therapeutic strategies remain limited ...
Yun Chen, Lingling Jiang, Dongxiao Yao, Dandan Liu, Yuesong Pan, Yilong Wang   +5 more
doaj   +1 more source

Structural Alterations of Segmented Macular Inner Layers in Aquaporin4-Antibody-Positive Optic Neuritis Patients in a Chinese Population. [PDF]

PLoS ONE, 2016
This study aimed to analyse the structural injury of the peripapillary retinal nerve fibre layer (pRNFL) and segmented macular layers in optic neuritis (ON) in aquaporin4-antibody (AQP4-Ab) seropositivity(AQP4-Ab-positiveON) patients and in AQP4-Ab ...
Chunxia Peng, Wei Wang, Quangang Xu, Shuo Zhao, Hongyang Li, Mo Yang, Shanshan Cao, Huanfen Zhou, Shihui Wei   +8 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. [PDF]

PLoS ONE, 2010
Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass. However, a role for AQP4-specific T cells in this CNS inflammatory disease is not known.
Patricia A Nelson, Mojgan Khodadoust, Thomas Prodhomme, Collin Spencer, Juan Carlos Patarroyo, Michel Varrin-Doyer, Joseph D Ho, Robert M Stroud, Scott S Zamvil   +8 more
doaj   +1 more source

AQP4 Aggregation State Is a Determinant for Glioma Cell Fate [PDF]

Cancer Research, 2019
Abstract The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms. The isoform ratio controls AQP4 aggregation into supramolecular structures called orthogonal arrays of particles (AQP4-OAP).
Laura Simone, Francesco Pisani, Maria G. Mola, Manuela De Bellis, Giuseppe Merla, Lucia Micale, Antonio Frigeri, Angelo L. Vescovi, Maria Svelto, Grazia P. Nicchia   +9 more
openaire   +5 more sources