Results 51 to 60 of about 23,657 (257)
Toward New AQP4 Inhibitors: ORI-TRN-002
International Journal of Molecular Sciences, 2023 Cerebral edema is a life-threatening condition that can cause permanent brain damage or death if left untreated. Existing therapies aim at mitigating the associated elevated intracranial pressure, yet they primarily alleviate pressure rather than prevent edema formation. Prophylactic anti-edema therapy necessitates novel drugs targeting edema formation.
Michael Thormann +6 more
openaire +3 more sources
, 2015 (A) Analysis of AQP4 IgG binding on E21 (M23 enriched fraction), E27 (M1 enriched fraction) and total extract using a pool of High (H) and of Low (L) titer sera each from five different NMO patients.
Maddalena Ruggieri (485748) +10 more
core +1 more source
Nitric oxide conduction by the brain aquaporin AQP4 [PDF]
Proteins: Structure, Function, and Bioinformatics, 2009 AbstractInvolvement of aquaporins in gas conduction across the membrane and the physiological significance of this process have attracted marked attention from both experimental and theoretical studies. Previous work demonstrated that AQP1 is permeable to both CO2 and O2.
Yi, Wang, Emad, Tajkhorshid
openaire +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec +6 more
wiley +1 more source
Frontiers in Immunology, 2018 Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders causing significant morbidities and mortality. The majority of NMOSD patients have autoimmunity against aquaporin-4 (AQP4), evidenced by seropositivity for ...
Leung-Wah Yick +9 more
doaj +1 more source
, 2015 Semiquantitative immunoblotting of kidney protein prepared from inner medulla. Immunoblot was reacted with anti-AQP4 antibody and reveals a single ~ 34.5 kDa AQP4-band (A-E). Data are presented in Table 10.
Sophie Constantin Lütken (689916) +2 more
core +1 more source
direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate [PDF]
, 2014 Background Neuromyelitis optica (NMO, Devic syndrome) is associated with antibodies to aquaporin-4 (NMO-IgG/AQP4-Ab) in the majority of cases. NMO- IgG/AQP4-Ab seropositivity in patients with NMO and its spectrum disorders has important differential ...
Jarius, Sven +9 more
core +1 more source
Neuropsychiatry, 2018 Objectives: In this study, we investigated AQP4 expression in injured astrocytes in vitro, as well as the influence of AQP4 levels on pathology using gene silencing. Methods: Astrocytes were cultured and the mechanical scratch method was used to simulate an injury.
Jianqiang Chen, Qingjie Xia, Hong Lu
openaire +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2020 Haoyue Zhu, Mengqi Zhang, Yujiao Fu, Hongyu Long, Wenbiao Xiao, Li Feng, Bo Xiao, Luo Zhou Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Luo ZhouDepartment of ...
Zhu H +7 more
doaj