Results 51 to 60 of about 18,333 (223)

Aquaporin-4 Autoantibodies From Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice

Frontiers in Immunology, 2018
Neuromyelitis optica spectrum disorders (NMOSD) are central nervous system inflammatory disorders causing significant morbidities and mortality. The majority of NMOSD patients have autoimmunity against aquaporin-4 (AQP4), evidenced by seropositivity for ...
Leung-Wah Yick, Leung-Wah Yick, Oscar Ka-Fai Ma, Oscar Ka-Fai Ma, Roy Chun-Laam Ng, Roy Chun-Laam Ng, Jason Shing-Cheong Kwan, Jason Shing-Cheong Kwan, Koon-Ho Chan, Koon-Ho Chan   +9 more
doaj   +1 more source

Aquaporin4 (AQP4) in brain disorder

Folia Pharmacologica Japonica, 2019
Two third of our body is composed of water molecules. Regulation of water and electrolytes is indeed the most important homeostatic functions. Many diseases, such as heart failure, are associated with disturbance in fluid homeostasis. Surprisingly, water dynamics inside the brain is still largely unknown.
openaire   +3 more sources

Nitric oxide conduction by the brain aquaporin AQP4 [PDF]

Proteins: Structure, Function, and Bioinformatics, 2009
AbstractInvolvement of aquaporins in gas conduction across the membrane and the physiological significance of this process have attracted marked attention from both experimental and theoretical studies. Previous work demonstrated that AQP1 is permeable to both CO2 and O2.
Yi, Wang, Emad, Tajkhorshid
openaire   +2 more sources

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Changes in AQP4 expression and the pathology of injured cultured astrocytes after AQP4 mRNA silencing

Neuropsychiatry, 2018
Objectives: In this study, we investigated AQP4 expression in injured astrocytes in vitro, as well as the influence of AQP4 levels on pathology using gene silencing. Methods: Astrocytes were cultured and the mechanical scratch method was used to simulate an injury.
Jianqiang Chen, Qingjie Xia, Hong Lu
openaire   +1 more source

The Structure of AQP4 and Its Relationship to Disease

The FASEB Journal, 2021
Aquaporin‐4 (AQP4) is the most common water channel protein in the central nervous system (Flippidis, Carozza, & Rekate, 2016). It is highly concentrated in the cell membrane of the astrocytic endfeet, which form the blood‐brain barrier (BBB) and help protect the brain from toxins (Mader & Brimberg, 2019; Woodruff & Götz, 2018).
Koyuki Yamada, Ishani Pidara
openaire   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Effects of AQP4 and KCNJ10 Gene Polymorphisms on Drug Resistance and Seizure Susceptibility in Chinese Han Patients with Focal Epilepsy

Neuropsychiatric Disease and Treatment, 2020
Haoyue Zhu, Mengqi Zhang, Yujiao Fu, Hongyu Long, Wenbiao Xiao, Li Feng, Bo Xiao, Luo Zhou Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Luo ZhouDepartment of ...
Zhu H, Zhang M, Fu Y, Long H, Xiao W, Feng L, Xiao B, Zhou L   +7 more
doaj  

Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

Journal of Neuroinflammation, 2010
Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
Jarius Sven, Franciotta Diego, Paul Friedemann, Ruprecht Klemens, Bergamaschi Roberto, Rommer Paulus S, Reuss Reinhard, Probst Christian, Kristoferitsch Wolfgang, Wandinger Klaus, Wildemann Brigitte   +10 more
doaj   +1 more source

AQP4 knockout promotes neurite outgrowth via upregulating GAP43 expression in infant rats with hypoxic‐ischemic brain injury

Ibrain, 2022
Neonatal hypoxic‐ischemic encephalopathy (NHIE) induces severe cerebral damage and neurological dysfunction, with seldom effective therapy. Aquaporin‐4 (AQP4) is involved in aggravating brain damage induced by NHIE.
Qi‐Qin Dan, Zheng Ma, Ya‐Xin Tan, Belegu Visar, Li Chen   +4 more
doaj   +1 more source