Results 31 to 40 of about 23,657 (257)
Frontiers in Neurology, 2021 Background: Neuromyelitis optica spectrum disorder (NMOSD) is a clinically defined, inflammatory central nervous system (CNS) disease of unknown cause, associated with humoral autoimmune findings such as anti-aquaporin 4 (AQP4)-IgG.
Oliver Schmetzer +18 more
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Glymphatic system, AQP4, and their implications in Alzheimer’s disease [PDF]
Neurological Research and Practice, 2021 AbstractLacking conventional lymphatic system, the central nervous system requires alternative clearance systems, such as the glymphatic system, which promotes clearance of interstitial solutes. Aquaporin-4 water channels (AQP4) are an integral part of this system and related to neuropathologies, such as Alzheimer’s disease (AD).
Inês Silva +3 more
openaire +3 more sources
, 2021 The graph represents the standard curve obtained with the ELISA kit (A). The table indicates the type of sample, the mean AQP4 concentration per group including all analyzed samples (central column), the mean AQP4 concentration when only the samples with
Maria Bernal (11512738) +11 more
core +1 more source
Drug Treatment of Neuromyelitis Optica Spectrum Disorders: Out with the Old, in with the New?
ImmunoTargets and Therapy, 2021 Friederike Held, Ana-Katharina Klein, Achim Berthele Department of Neurology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, GermanyCorrespondence: Achim BertheleDepartment of Neurology, School of Medicine, Klinikum
Held F, Klein AK, Berthele A
doaj
Ecotoxicology and Environmental Safety, 2022 1,2-Dichloroethane (1,2-DCE) is a pervasive environmental pollutant, and overexposure to this hazardous material causes brain edema and demyelination in humans. We found that 1,2-DCE inhibits aquaporin 4 (AQP4) and is a primary pathogenic effector of 1,2-
Yizhou Zhong +14 more
doaj +1 more source
Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays, with models of AQP4 lattice assembly [PDF]
Neuroscience, 2004 Each day, approximately 0.5-0.9 l of water diffuses through (primarily) aquaporin-1 (AQP1) channels in the human choroid plexus, into the cerebrospinal fluid of the brain ventricles and spinal cord central canal, through the ependymal cell lining, and into the parenchyma of the CNS. Additional water is also derived from metabolism of glucose within the
J E, Rash +3 more
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An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment. [PDF]
PLoS ONE, 2012 Aquaporin-4 (AQP4), the main water channel of the brain, is highly expressed in animal glioma and human glioblastoma in situ. In contrast, most cultivated glioma cell lines don't express AQP4, and primary cell cultures of human glioblastoma lose it ...
Susan Noell +4 more
doaj +1 more source
Cells, 2023 We assessed interactions between the astrocytic volume-regulated anion channel (VRAC) and aquaporin 4 (AQP4) in the supraoptic nucleus (SON). Acute SON slices and cultures of hypothalamic astrocytes prepared from rats received hyposmotic challenge (HOC ...
Yang Liu +11 more
doaj +1 more source
A Pilot Study Evaluating the Effect of Artesunate on Glymphatic-Related Fluid Transport in Parkinson's Disease Mouse Models In Vivo and Ex Vivo. [PDF]
CNS Neurosci TherArtesunate (ART) treatment was associated with enhanced glymphatic CSF‐ISF exchange in both wild‐type (WT) and A53T mouse models of Parkinson's disease, with regional differences observed by dynamic MRI. In A53T mice, ART was associated with restoration of AQP4 polarization and reduced α‐syn levels in the SN.
Han WT +7 more
europepmc +2 more sources
Frontiers in Molecular Neuroscience, 2017 The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang +8 more
doaj +1 more source