Results 31 to 40 of about 18,333 (223)

Anti-aquaporin 4 IgG Is Not Associated With Any Clinical Disease Characteristics in Neuromyelitis Optica Spectrum Disorder

Frontiers in Neurology, 2021
Background: Neuromyelitis optica spectrum disorder (NMOSD) is a clinically defined, inflammatory central nervous system (CNS) disease of unknown cause, associated with humoral autoimmune findings such as anti-aquaporin 4 (AQP4)-IgG.
Oliver Schmetzer, Oliver Schmetzer, Oliver Schmetzer, Elisa Lakin, Elisa Lakin, Elisa Lakin, Ben Roediger, Ankelien Duchow, Ankelien Duchow, Ankelien Duchow, Susanna Asseyer, Susanna Asseyer, Susanna Asseyer, Friedemann Paul, Friedemann Paul, Friedemann Paul, Nadja Siebert, Nadja Siebert, Nadja Siebert   +18 more
doaj   +1 more source

Neuroimmunological Implications of AQP4 in Astrocytes [PDF]

International Journal of Molecular Sciences, 2016
The brain has high-order functions and is composed of several kinds of cells, such as neurons and glial cells. It is becoming clear that many kinds of neurodegenerative diseases are more-or-less influenced by astrocytes, which are a type of glial cell.
openaire   +2 more sources

Drug Treatment of Neuromyelitis Optica Spectrum Disorders: Out with the Old, in with the New?

ImmunoTargets and Therapy, 2021
Friederike Held, Ana-Katharina Klein, Achim Berthele Department of Neurology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, GermanyCorrespondence: Achim BertheleDepartment of Neurology, School of Medicine, Klinikum
Held F, Klein AK, Berthele A
doaj  

Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays, with models of AQP4 lattice assembly [PDF]

Neuroscience, 2004
Each day, approximately 0.5-0.9 l of water diffuses through (primarily) aquaporin-1 (AQP1) channels in the human choroid plexus, into the cerebrospinal fluid of the brain ventricles and spinal cord central canal, through the ependymal cell lining, and into the parenchyma of the CNS. Additional water is also derived from metabolism of glucose within the
J E, Rash, K G V, Davidson, T, Yasumura, C S, Furman   +3 more
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AQP4, Astrogenesis, and Hydrocephalus: A New Neurological Perspective

International Journal of Molecular Sciences, 2022
Aquaporin 4 (AQP4) is a cerebral glial marker that labels ependymal cells and astrocytes’ endfeet and is the main water channel responsible for the parenchymal fluid balance. However, in brain development, AQP4 is a marker of glial stem cells and plays a crucial role in the pathophysiology of pediatric hydrocephalus.
Leandro Castañeyra-Ruiz, Ibrahim González-Marrero, Luis G. Hernández-Abad, Seunghyun Lee, Agustín Castañeyra-Perdomo, Michael Muhonen   +5 more
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1,2-Dichloroethane induces cortex demyelination by depressing myelin basic protein via inhibiting aquaporin 4 in mice

Ecotoxicology and Environmental Safety, 2022
1,2-Dichloroethane (1,2-DCE) is a pervasive environmental pollutant, and overexposure to this hazardous material causes brain edema and demyelination in humans. We found that 1,2-DCE inhibits aquaporin 4 (AQP4) and is a primary pathogenic effector of 1,2-
Yizhou Zhong, Boxuan Liang, Hao Meng, Rongyi Ye, Zhiming Li, Jiaxin Du, Bo Wang, Bingli Zhang, Yuji Huang, Xi Lin, Manjiang Hu, Weifeng Rong, Qinghong Wu, Xingfen Yang, Zhenlie Huang   +14 more
doaj   +1 more source

Interactions between the Astrocytic Volume-Regulated Anion Channel and Aquaporin 4 in Hyposmotic Regulation of Vasopressin Neuronal Activity in the Supraoptic Nucleus

Cells, 2023
We assessed interactions between the astrocytic volume-regulated anion channel (VRAC) and aquaporin 4 (AQP4) in the supraoptic nucleus (SON). Acute SON slices and cultures of hypothalamic astrocytes prepared from rats received hyposmotic challenge (HOC ...
Yang Liu, Xiao-Ran Wang, Yun-Hao Jiang, Tong Li, Shuo Ling, Hong-Yang Wang, Jia-Wei Yu, Shu-Wei Jia, Xiao-Yu Liu, Chun-Mei Hou, Vladimir Parpura, Yu-Feng Wang   +11 more
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A Case of Longitudinal Extensive Transversal Myelitis in Patient With Neuromyelitis Optica Spectrum Disorder and Systemic Lupus Erythematosus. [PDF]

Clin Case Rep
ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune, demyelinating disorder of the central nervous system. Clinical manifestations include optic neuritis, longitudinally extensive transverse myelitis (LETM) involving three or more vertebral segments, and, in most cases, seropositivity for anti‐aquaporin‐4 antibodies (AQP4‐IgG).
Pravdic N, Goluza M, Pejanovic Skobic N, Batinic D, Zovko J, Zovko T, Ivankovic A, Klupka Saric I.   +7 more
europepmc   +2 more sources

An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment. [PDF]

PLoS ONE, 2012
Aquaporin-4 (AQP4), the main water channel of the brain, is highly expressed in animal glioma and human glioblastoma in situ. In contrast, most cultivated glioma cell lines don't express AQP4, and primary cell cultures of human glioblastoma lose it ...
Susan Noell, Rainer Ritz, Karen Wolburg-Buchholz, Hartwig Wolburg, Petra Fallier-Becker   +4 more
doaj   +1 more source

Biology of AQP4 and Anti‐AQP4 Antibody: Therapeutic Implications for NMO

Brain Pathology, 2013
AbstractThe water channel aquaporin‐4 (AQP4) is the target of the immunoglobulin G autoantibody (AQP4‐IgG) in neuromyelitis optica (NMO). AQP4 is expressed in foot processes of astrocytes throughout the central nervous system, as well as in skeletal muscle and epithelial cells in kidney, lung and gastrointestinal organs.
A S, Verkman, Puay-Wah, Phuan, Nithi, Asavapanumas, Lukmanee, Tradtrantip   +3 more
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