Results 31 to 40 of about 18,179 (218)
Biology of
Brain Pathology, 2013 AbstractThe water channel aquaporin‐4 (AQP4) is the target of the immunoglobulin G autoantibody (AQP4‐IgG) in neuromyelitis optica (NMO). AQP4 is expressed in foot processes of astrocytes throughout the central nervous system, as well as in skeletal muscle and epithelial cells in kidney, lung and gastrointestinal organs.
A S, Verkman +3 more
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Frontiers in Molecular Neuroscience, 2017 The impairment of amyloid-β (Aβ) clearance in the brain plays a causative role in Alzheimer’s disease (AD). Polarity distribution of aquaporin-4 (AQP4) is important to remove Aβ from brain.
Jingzhu Zhang +8 more
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Toward New AQP4 Inhibitors: ORI-TRN-002
International Journal of Molecular Sciences, 2023 Cerebral edema is a life-threatening condition that can cause permanent brain damage or death if left untreated. Existing therapies aim at mitigating the associated elevated intracranial pressure, yet they primarily alleviate pressure rather than prevent edema formation. Prophylactic anti-edema therapy necessitates novel drugs targeting edema formation.
Michael Thormann +6 more
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Frontiers in Physiology, 2012 The role of aquaporin water channels in Elasmobanchs such as the dogfish Squalus acanthias is completely unknown. This investigation determines the expression and cellular and sub-cellular localization of AQP4 protein in dogfish tissues.
Christopher P Cutler +7 more
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Correlations of AQP4 expression and polymorphism with diabetic retinopathy.
European review for medical and pharmacological sciences, 2021 The aim of this study was to investigate the relationships of aquaporin 4 (AQP4) rs200498749, rs149465 and rs650217 polymorphisms and gene expression with diabetic retinopathy (DR).A total of 400 patients with diabetes mellitus (DM) treated in our hospital were enrolled in this study. All subjects were divided into two groups, including DM group (n=200,
Zhou, X., Cheng, F.-C., Wang, H.-L.
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Müller cell markers in aqueous humor of patients with type-2 macular telangiectasia
Indian Journal of OphthalmologyPurpose: To investigate the pathogenesis of type-2 macular telangiectasia (MacTel) by comparing the levels of glial fibrillary acidic protein (GFAP), aquaporin-4 (AQP4), and K+ inwardly rectifying channel 4.1 (Kir4.1) in the aqueous humor of diagnosed ...
Elçin Osmanlı +4 more
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Aquaporin 4 expression is downregulated in large bovine ovarian follicles
Journal of Animal Reproduction and Biotechnology, 2020 Aquaporin channels (AQPs) are known to play an important role in the development of ovarian follicles through their function in water transport pathways. Compared to other AQPs, research on the role of AQP4 in female reproductive physiology, particularly
Chang-Woon Kim +5 more
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The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory
Frontiers in Integrative Neuroscience, 2016 Aquaporin-4 (AQP4) is the predominant water channel expressed by astrocytes in the central nervous system. AQP4 is widely expressed throughout the brain, especially at the blood-brain barrier where AQP4 is highly polarized to astrocytic foot processes ...
Jenny I. Szu, Devin K. Binder
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Aquaporin-4 Expression during Toxic and Autoimmune Demyelination
Cells, 2020 The water channel protein aquaporin-4 (AQP4) is required for a normal rate of water exchange across the blood–brain interface. Following the discovery that AQP4 is a possible autoantigen in neuromyelitis optica, the function of AQP4 in health and disease
Sven Olaf Rohr +6 more
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Role of AQP4 in skeletal muscle
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018 n ...
Frigeri, Antonio, Paola, Nicchia G
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