Results 11 to 20 of about 23,657 (257)
AQP4 and AQP4‐IgG in NMO [PDF]
Brain Pathology, 2013 The water channel aquaporin-4 (AQP4) is the target of the immunoglobulin G autoantibody (AQP4-IgG) in neuromyelitis optica (NMO). AQP4 is expressed in foot processes of astrocytes throughout the central nervous system, as well as in skeletal muscle and ...
Phuan, Puay‐Wah +7 more
core +6 more sources
AQP4 and the fate of gliomas [PDF]
Cancer Research, 2019 High-grade glioma is the most common primary brain cancer type and is characterized by invasive and fast growth. In a previous issue of Cancer Research, Simone and colleagues show that the two isoforms of the aquaporin-4 (AQP4) water channel may ...
Amiry-Moghaddam, Mahmood
core +5 more sources
Neuroimmunological Implications of AQP4 in Astrocytes [PDF]
International Journal of Molecular Sciences, 2016 The brain has high-order functions and is composed of several kinds of cells, such as neurons and glial cells. It is becoming clear that many kinds of neurodegenerative diseases are more-or-less influenced by astrocytes, which are a type of glial cell ...
Hiroko Ikeshima-Kataoka
core +3 more sources
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on AQP4 (aquaporin 4), with data on DNA, on the protein encoded, and where the gene is ...
Ribatti, D +3 more
core +4 more sources
AQP4 Aggregation State Is a Determinant for Glioma Cell Fate [PDF]
Cancer Research, 2019 The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms. The isoform ratio controls AQP4 aggregation into supramolecular structures called orthogonal arrays of particles ...
Simone, Laura +9 more
core +8 more sources
Regulation of AQP4 in the Central Nervous System [PDF]
International Journal of Molecular Sciences, 2020 Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in CNS water and potassium homeostasis.
Masato Yasui, Arno Vandebroek
core +3 more sources
BiochemistryAQP4-IgG is an autoantibody associated with neuromyelitis optica spectroscopic disorder (NMOSD), a central nervous system inflammatory disease that requires early diagnosis and treatment.
Shubei Ma (18177127) +5 more
core +3 more sources
In the brain, the water channel Aquaporin 4 (AQP4) is largely restricted to astrocytes, enriched at perivascular astrocytic processes, and involved in fluid balance and neurological disease.
Sadan Dahal +6 more
core +2 more sources
Regulation and Function of AQP4 in the Central Nervous System
Neurochemical Research, 2015 Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface.
Assentoft, Mette +2 more
core +4 more sources
The Comprehensive Live Cell-Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD. [PDF]
Ann Clin Transl NeurolABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xu X +10 more
europepmc +2 more sources