Results 11 to 20 of about 24,501 (255)
AQP4 and the Fate of Gliomas [PDF]
Cancer Research, 2019 Abstract High-grade glioma is the most common primary brain cancer type and is characterized by invasive and fast growth. In a previous issue of Cancer Research, Simone and colleagues show that the two isoforms of the aquaporin-4 (AQP4) water channel may determine the fate of gliomas.
Amiry-Moghaddam, Mahmood
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Biology of
Brain Pathology, 2013 AbstractThe water channel aquaporin‐4 (AQP4) is the target of the immunoglobulin G autoantibody (AQP4‐IgG) in neuromyelitis optica (NMO). AQP4 is expressed in foot processes of astrocytes throughout the central nervous system, as well as in skeletal muscle and epithelial cells in kidney, lung and gastrointestinal organs.
A S, Verkman +3 more
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Neuroimmunological Implications of AQP4 in Astrocytes [PDF]
International Journal of Molecular Sciences, 2016 The brain has high-order functions and is composed of several kinds of cells, such as neurons and glial cells. It is becoming clear that many kinds of neurodegenerative diseases are more-or-less influenced by astrocytes, which are a type of glial cell.
Hiroko Ikeshima-Kataoka
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AQP4 Aggregation State Is a Determinant for Glioma Cell Fate [PDF]
Cancer Research, 2019 Abstract The glial water channel protein aquaporin-4 (AQP4) forms heterotetramers in the plasma membrane made of the M23-AQP4 and M1-AQP4 isoforms. The isoform ratio controls AQP4 aggregation into supramolecular structures called orthogonal arrays of particles (AQP4-OAP).
Laura Simone +9 more
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Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on AQP4 (aquaporin 4), with data on DNA, on the protein encoded, and where the gene is implicated.
RIBATTI, Domenico, NICO, Beatrice
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BiochemistryAQP4-IgG is an autoantibody associated with neuromyelitis optica spectroscopic disorder (NMOSD), a central nervous system inflammatory disease that requires early diagnosis and treatment. We designed two fusion proteins, AQP4-DARPin1 and AQP4-DARPin2, comprising the complete antigenic epitopes of aquaporin-4 (AQP4) and the constant region of the ...
Xiaofei Wang +5 more
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Regulation and Function of AQP4 in the Central Nervous System
Neurochemical Research, 2015 Aquaporin 4 (AQP4) is the predominant water channel in the mammalian brain and is mainly expressed in the perivascular glial endfeet at the brain-blood interface. Based on studies on AQP4(-/-) mice, AQP4 has been assigned physiological roles in stimulus-induced K(+) clearance, paravascular fluid flow, and brain edema formation.
Assentoft, Mette +2 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2012 【目的】 研究表达不同亚型的AQP4细胞系检测中国人群视神经脊髓炎患者血清中AQP4抗体的敏感性? 【方法】 根据纳入标准共获取血清205例,其中包括视神经脊髓炎40例,长节段性脊髓炎39例,复发性视神经炎39例,多发性硬化47例,另设40例健康对照?使用稳定表达水通道蛋白4的四种细胞系HEK293/pcDNA3.1(+)-M23-AQP4?HEK293/pcDNA3.1(+)-M1-AQP4、HEK293/pEGFP-N3-M23-AQP4?HEK293/pEGFP-N3-M1 ...
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Aquaporin-4 autoantibodies in Neuromyelitis Optica: AQP4 isoform-dependent sensitivity and specificity. [PDF]
PLoS ONE, 2013 Neuromyelitis Optica (NMO) is an autoimmune demyelinating disease, characterized by the presence of autoantibody (NMO-IgG) to Aquaporin-4 (AQP4). NMO-IgG identification supports NMO diagnosis and several diagnostic tests have been developed, but their ...
Francesco Pisani +8 more
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AQP4-specific T cells determine lesion localization in the CNS in a model of NMOSD [PDF]
Acta Neuropathologica CommunicationsNeuromyelitis optica spectrum disorder (NMOSD) is a paradigmatic autoimmune disease of the central nervous system (CNS), in which the water channel protein Aquaporin-4 (AQP4) is targeted by a self-reactive immune response.
Ali Maisam Afzali +7 more
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