Results 11 to 20 of about 18,179 (218)

Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Aquaporin‐4 (AQP4) is thought to facilitate Alzheimer's disease (AD) protein clearance during sleep. We examined whether AQP4 genetic variation was associated with AD pathology or modified the association between sleep duration and AD biomarkers.
Palatsides EL, Yiallourou S, Himali D, Cavuoto MG, Baril AA, Yang Q, Peloso GM, Ryan J, El Fakhri G, Ghosh S, Thibault E, DeCarli CS, Johnson KA, Beiser AS, Seshadri S, Himali JJ, Pase MP.   +16 more
europepmc   +2 more sources

AQP4 (aquaporin 4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013
Review on AQP4 (aquaporin 4), with data on DNA, on the protein encoded, and where the gene is implicated.
RIBATTI, Domenico, NICO, Beatrice
openaire   +2 more sources

Evidence for direct and sleep-moderated relationships between aquaporin-4 genetic variants and Alzheimer's disease phenotypes. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Variants in the aquaporin‐4 gene (AQP4) have been associated with Alzheimer's disease (AD) diagnosis, cognition, and brain amyloid beta (Aβ) and may affect the sleep and Aβ relationship. Their association with other AD‐related phenotypes/disease progression remain largely unknown.
Porter T, Armstrong AM, O'Brien EK, Doré V, Bourgeat P, Turner M, Maruff P, Rowe CC, Brown BM, Villemagne VL, Rainey-Smith SR, Laws SM, AIBL Research Group.   +12 more
europepmc   +2 more sources

Late-Onset Neuromyelitis Optica Spectrum Disorder Mimicking a Non-Arteritic Anterior Ischemic Optic Neuropathy–Case Report

Türk Oftalmoloji Dergisi, 2023
A 60-year-old white woman presented to the emergency department with painless decrease of visual acuity in the left eye (LE). The diagnosis of a non-arteritic anterior ischemic optic neuropathy in the LE was established based on the clinical picture and ...
Lech Sedlak, Marta Swierczynska, Dorota Wygledowska Promienska   +2 more
doaj   +1 more source

Evaluation of gliovascular functions of Aqp4 readthrough isoforms

Frontiers in Cellular Neuroscience, 2023
Abstract Aquaporin-4 (AQP4) is a water channel protein that links astrocytic endfeet to the blood-brain barrier (BBB) and regulates water and potassium homeostasis in the brain, as well as the glymphatic clearance of waste products that would otherwise potentiate neurological diseases.
Shayna M. Mueller, Shayna M. Mueller, Kelli McFarland White, Kelli McFarland White, Stuart B. Fass, Stuart B. Fass, Siyu Chen, Siyu Chen, Siyu Chen, Zhan Shi, Xia Ge, Xia Ge, John A. Engelbach, John A. Engelbach, Seana H. Gaines, Annie R. Bice, Michael J. Vasek, Michael J. Vasek, Joel R. Garbow, Joel R. Garbow, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Zila Martinez-Lozada, Martine Cohen-Salmon, Joseph D. Dougherty, Joseph D. Dougherty, Joseph D. Dougherty, Darshan Sapkota, Darshan Sapkota   +31 more
openaire   +5 more sources

AQP4-IgG Immunoprecipitation Assay Optimization [PDF]

Clinical Chemistry, 2009
The sensitivity and specificity of tissue-based immunofluorescence assays (IFA)1 is established for detecting neuromyelitis optica (NMO) IgG as an aid to classifying inflammatory demyelinating central nervous system disorders belonging to the NMO spectrum (1): NMO, partial and inaugural forms of NMO [longitudinally extensive transverse myelitis (≥3 ...
Metha, Apiwattanakul, Andrew, McKeon, James P, Fryer, Shannon R, Hinson, Sean J, Pittock, Vanda A, Lennon   +5 more
openaire   +2 more sources

Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder

Scientific Reports, 2021
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system. Most NMOSD patients are seropositive for immunoglobulin G (IgG) autoantibodies against astrocyte water channel aquaporin-4 (AQP4), called ...
Lukmanee Tradtrantip, Michael R. Yeaman, A. S. Verkman   +2 more
doaj   +1 more source

Glymphatic system, AQP4, and their implications in Alzheimer’s disease [PDF]

Neurological Research and Practice, 2021
AbstractLacking conventional lymphatic system, the central nervous system requires alternative clearance systems, such as the glymphatic system, which promotes clearance of interstitial solutes. Aquaporin-4 water channels (AQP4) are an integral part of this system and related to neuropathologies, such as Alzheimer’s disease (AD).
Inês Silva, Jéssica Silva, Rita Ferreira, Diogo Trigo   +3 more
openaire   +3 more sources

A Bioinformatics Analysis of the Potential Roles of Aquaporin 4 in Human Brain Tumors: An Immune-Related Process

Frontiers in Pharmacology, 2021
Aquaporin 4 (AQP4) is an ubiquitously expressed membrane protein channel found in the central nervous system and mainly on astrocytes. Recent studies on AQP4 has implicated it in tumorigenesis.
Shuang Zou, Shuang Zou, Shuang Zou, Yu-Long Lan, Yu-Long Lan, Yu-Long Lan, Tong Ren, Xiangyu Li, Lijun Zhang, Hongjin Wang, Xun Wang   +10 more
doaj   +1 more source

Protection of Vascular Endothelial Growth Factor to Brain Edema Following Intracerebral Hemorrhage and Its Involved Mechanisms: Effect of Aquaporin-4. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor (VEGF) has protective effects on many neurological diseases. However, whether VEGF acts on brain edema following intracerebral hemorrhage (ICH) is largely unknown.
Heling Chu, Yuping Tang, Qiang Dong
doaj   +1 more source