Results 21 to 30 of about 24,501 (255)

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Filippatou AG, Dominguez-Penuela S, Acero-Garces D, Gakis G, Smith MD, Resto Y, Reyes-Mantilla M, Chen H, Hernandez I, Said Y, Salazar-Camelo A, Huynh C, Tassoni A, Yednock T, Artis R, Andrews-Zwilling Y, Newsome SD, Saidha S, Bhargava P, Mowry EM, Fitzgerald KC, Calabresi PA, Pardo CA, Sotirchos ES.   +23 more
europepmc   +2 more sources

The Comprehensive Live Cell-Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xu X, Ding J, Du Y, Luo G, Li J, Liu R, Xu X, Li X, Li M, Jiang W, Yang C.   +10 more
europepmc   +2 more sources

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D-Serine Signaling. [PDF]

Adv Sci (Weinh)
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Han K, Jang MW, Park T, Kim KJ, Drew VJ, Kim S, Kim TY, Park MG, Kim M, Chung SW, Suh M, Lee CJ.   +11 more
europepmc   +2 more sources

Regulation of AQP4 in the Central Nervous System [PDF]

International Journal of Molecular Sciences, 2020
Aquaporin-4 (AQP4) is the main water channel protein expressed in the central nervous system (CNS). AQP4 is densely expressed in astrocyte end-feet, and is an important factor in CNS water and potassium homeostasis. Changes in AQP4 activity and expression have been implicated in several CNS disorders, including (but not limited to) epilepsy, edema ...
Vandebroek, Arno, Yasui, Masato
openaire   +2 more sources

Aquaporin-4 Orchestrates Muscle Cell Differentiation and Satellite Cell Preservation: A Novel Target in Age-Related Muscle Decline. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Impaired muscle regeneration is a key contributor to age‐related muscle decline, yet the molecular mechanisms linking muscle water homeostasis to regenerative failure remain incompletely understood. Aquaporin‐4 (AQP4), a major skeletal muscle water channel, may have functions beyond water transport that are relevant to muscle ...
Girón MD, Manzano M, Pereira SL, Reinoso A, Burgio C, Montero-Martin N, Jiménez-Jiménez G, Argilés JM, Rueda R, López-Pedrosa JM, Salto R.   +10 more
europepmc   +2 more sources

Evaluation of gliovascular functions of Aqp4 readthrough isoforms

Frontiers in Cellular Neuroscience, 2023
Abstract Aquaporin-4 (AQP4) is a water channel protein that links astrocytic endfeet to the blood-brain barrier (BBB) and regulates water and potassium homeostasis in the brain, as well as the glymphatic clearance of waste products that would otherwise potentiate neurological diseases.
Shayna M. Mueller, Shayna M. Mueller, Kelli McFarland White, Kelli McFarland White, Stuart B. Fass, Stuart B. Fass, Siyu Chen, Siyu Chen, Siyu Chen, Zhan Shi, Xia Ge, Xia Ge, John A. Engelbach, John A. Engelbach, Seana H. Gaines, Annie R. Bice, Michael J. Vasek, Michael J. Vasek, Joel R. Garbow, Joel R. Garbow, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Zila Martinez-Lozada, Martine Cohen-Salmon, Joseph D. Dougherty, Joseph D. Dougherty, Joseph D. Dougherty, Darshan Sapkota, Darshan Sapkota   +31 more
openaire   +5 more sources

AQP4-IgG Immunoprecipitation Assay Optimization [PDF]

Clinical Chemistry, 2009
The sensitivity and specificity of tissue-based immunofluorescence assays (IFA)1 is established for detecting neuromyelitis optica (NMO) IgG as an aid to classifying inflammatory demyelinating central nervous system disorders belonging to the NMO spectrum (1): NMO, partial and inaugural forms of NMO [longitudinally extensive transverse myelitis (≥3 ...
Metha, Apiwattanakul, Andrew, McKeon, James P, Fryer, Shannon R, Hinson, Sean J, Pittock, Vanda A, Lennon   +5 more
openaire   +2 more sources

Aquaporin 4 is a ubiquitously expressed isoform in the dogfish (Squalus acanthias) shark [PDF]

, 2012
Christopher P.Cutler is in receipt of a grant from the National Science Foundation, NSFIOS0844818.The dogfish ortholog of aquaporin 4 (AQP4) was amplified from cDNA using degenerate PCR followed by cloning and sequencing.
MacIver, Bryce, Cutler, Christopher P, Cutler, Christopher P., Mark eZeidel, Cramb, Gordon, Gordon Cramb, Christopher P Cutler, McIver, Bryce, Gordon eCramb, Mark Zeidel, Zeidel, Mark, Zeidel, Mark L., Bryce MacIver, Cutler, Christopher Paul, Bryce eMcIver, Christopher P Cutler, Cramb, Gordon; id_orcid   +16 more
core   +1 more source

Protection of Vascular Endothelial Growth Factor to Brain Edema Following Intracerebral Hemorrhage and Its Involved Mechanisms: Effect of Aquaporin-4. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor (VEGF) has protective effects on many neurological diseases. However, whether VEGF acts on brain edema following intracerebral hemorrhage (ICH) is largely unknown.
Heling Chu, Yuping Tang, Qiang Dong
doaj   +1 more source

Glymphatic system, AQP4, and their implications in Alzheimer’s disease [PDF]

Neurological Research and Practice, 2021
AbstractLacking conventional lymphatic system, the central nervous system requires alternative clearance systems, such as the glymphatic system, which promotes clearance of interstitial solutes. Aquaporin-4 water channels (AQP4) are an integral part of this system and related to neuropathologies, such as Alzheimer’s disease (AD).
Inês Silva, Jéssica Silva, Rita Ferreira, Diogo Trigo   +3 more
openaire   +3 more sources