Results 21 to 30 of about 23,657 (257)

Inebilizumab in AQP4-Seropositive NMOSD: One-Year Follow-Up From a Multicenter, Real-World Study. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Gui M, Zhan J, Li W, Jin T, He D, Tian D, Li Z, Lin J, Li Y, Zhou H, Bu B.   +10 more
europepmc   +2 more sources

HD-tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice. [PDF]

Adv Sci (Weinh)
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Li Z, Zhang Y, Tong Q, Gong Z, Zhang S, Qian Z, Zhang H, Yao Q, Li Q.   +8 more
europepmc   +2 more sources

表达AQP4不同亚型的细胞系检测AQP4抗体敏感性的研究

Zhongshan Daxue xuebao. Yixue kexue ban, 2012
【目的】 研究表达不同亚型的AQP4细胞系检测中国人群视神经脊髓炎患者血清中AQP4抗体的敏感性? 【方法】 根据纳入标准共获取血清205例,其中包括视神经脊髓炎40例,长节段性脊髓炎39例,复发性视神经炎39例,多发性硬化47例,另设40例健康对照?使用稳定表达水通道蛋白4的四种细胞系HEK293/pcDNA3.1(+)-M23-AQP4?HEK293/pcDNA3.1(+)-M1-AQP4、HEK293/pEGFP-N3-M23-AQP4?HEK293/pEGFP-N3-M1 ...
doaj   +1 more source

Astrocyte subtype-specific alterations in the dentate gyrus of individuals with mesial temporal lobe epilepsy. [PDF]

Epilepsia Open
Abstract Objective Epilepsy affects approximately 50 million people worldwide and, although primarily attributed to neuronal dysfunction, increasing evidence highlights a critical role of glial cells, particularly astrocytes, in the pathophysiological mechanisms.
Lötzsch C, Schmidt JJ, Delev D, Coras R, Blümcke I, Beckervordersandforth R.   +5 more
europepmc   +2 more sources

Evaluation of gliovascular functions of Aqp4 readthrough isoforms

Frontiers in Cellular Neuroscience, 2023
Abstract Aquaporin-4 (AQP4) is a water channel protein that links astrocytic endfeet to the blood-brain barrier (BBB) and regulates water and potassium homeostasis in the brain, as well as the glymphatic clearance of waste products that would otherwise potentiate neurological diseases.
Shayna M. Mueller, Shayna M. Mueller, Kelli McFarland White, Kelli McFarland White, Stuart B. Fass, Stuart B. Fass, Siyu Chen, Siyu Chen, Siyu Chen, Zhan Shi, Xia Ge, Xia Ge, John A. Engelbach, John A. Engelbach, Seana H. Gaines, Annie R. Bice, Michael J. Vasek, Michael J. Vasek, Joel R. Garbow, Joel R. Garbow, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Joseph P. Culver, Zila Martinez-Lozada, Martine Cohen-Salmon, Joseph D. Dougherty, Joseph D. Dougherty, Joseph D. Dougherty, Darshan Sapkota, Darshan Sapkota   +31 more
openaire   +5 more sources

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid-Beta Pathology in Alzheimer's Mice. [PDF]

Adv Sci (Weinh)
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Wu F, Fan J, Zhou X, Yang Z, Gong M, Huang M, Cai Z, Yang S, Teng T, Yang C, Li J, Wang H, Dai S, Chen C, Chen X, Wang M, Zhang K.   +16 more
europepmc   +2 more sources

A Bioinformatics Analysis of the Potential Roles of Aquaporin 4 in Human Brain Tumors: An Immune-Related Process

Frontiers in Pharmacology, 2021
Aquaporin 4 (AQP4) is an ubiquitously expressed membrane protein channel found in the central nervous system and mainly on astrocytes. Recent studies on AQP4 has implicated it in tumorigenesis.
Shuang Zou, Shuang Zou, Shuang Zou, Yu-Long Lan, Yu-Long Lan, Yu-Long Lan, Tong Ren, Xiangyu Li, Lijun Zhang, Hongjin Wang, Xun Wang   +10 more
doaj   +1 more source

Aquaporin 4 is a ubiquitously expressed isoform in the dogfish (Squalus acanthias) shark [PDF]

, 2012
Christopher P.Cutler is in receipt of a grant from the National Science Foundation, NSFIOS0844818.The dogfish ortholog of aquaporin 4 (AQP4) was amplified from cDNA using degenerate PCR followed by cloning and sequencing.
MacIver, Bryce, Cutler, Christopher P, Cutler, Christopher P., Mark eZeidel, Cramb, Gordon, Gordon Cramb, Christopher P Cutler, McIver, Bryce, Gordon eCramb, Mark Zeidel, Zeidel, Mark, Zeidel, Mark L., Bryce MacIver, Cutler, Christopher Paul, Bryce eMcIver, Christopher P Cutler   +15 more
core   +1 more source

AQP4-IgG Immunoprecipitation Assay Optimization [PDF]

Clinical Chemistry, 2009
The sensitivity and specificity of tissue-based immunofluorescence assays (IFA)1 is established for detecting neuromyelitis optica (NMO) IgG as an aid to classifying inflammatory demyelinating central nervous system disorders belonging to the NMO spectrum (1): NMO, partial and inaugural forms of NMO [longitudinally extensive transverse myelitis (≥3 ...
Metha, Apiwattanakul, Andrew, McKeon, James P, Fryer, Shannon R, Hinson, Sean J, Pittock, Vanda A, Lennon   +5 more
openaire   +2 more sources

Aquaporin-4 expression and modulation in a rat model of post-traumatic syringomyelia

Scientific Reports, 2023
Aquaporin-4 (AQP4) has been implicated in post-traumatic syringomyelia (PTS), a disease characterised by the formation of fluid-filled cysts in the spinal cord.
Joel A. Berliner, Magdalena A. Lam, Elmira Najafi, Sarah J. Hemley, Lynne E. Bilston, Marcus A. Stoodley   +5 more
doaj   +1 more source