Results 21 to 30 of about 18,179 (218)
Aquaporin-4 expression and modulation in a rat model of post-traumatic syringomyelia
Scientific Reports, 2023 Aquaporin-4 (AQP4) has been implicated in post-traumatic syringomyelia (PTS), a disease characterised by the formation of fluid-filled cysts in the spinal cord.
Joel A. Berliner +5 more
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AQP4 and the Fate of Gliomas [PDF]
Cancer Research, 2019 Abstract High-grade glioma is the most common primary brain cancer type and is characterized by invasive and fast growth. In a previous issue of Cancer Research, Simone and colleagues show that the two isoforms of the aquaporin-4 (AQP4) water channel may determine the fate of gliomas.
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Frontiers in Neurology, 2021 Background: Neuromyelitis optica spectrum disorder (NMOSD) is a clinically defined, inflammatory central nervous system (CNS) disease of unknown cause, associated with humoral autoimmune findings such as anti-aquaporin 4 (AQP4)-IgG.
Oliver Schmetzer +18 more
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Neuroimmunological Implications of AQP4 in Astrocytes [PDF]
International Journal of Molecular Sciences, 2016 The brain has high-order functions and is composed of several kinds of cells, such as neurons and glial cells. It is becoming clear that many kinds of neurodegenerative diseases are more-or-less influenced by astrocytes, which are a type of glial cell.
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Drug Treatment of Neuromyelitis Optica Spectrum Disorders: Out with the Old, in with the New?
ImmunoTargets and Therapy, 2021 Friederike Held, Ana-Katharina Klein, Achim Berthele Department of Neurology, School of Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, GermanyCorrespondence: Achim BertheleDepartment of Neurology, School of Medicine, Klinikum
Held F, Klein AK, Berthele A
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Freeze-fracture and immunogold analysis of aquaporin-4 (AQP4) square arrays, with models of AQP4 lattice assembly [PDF]
Neuroscience, 2004 Each day, approximately 0.5-0.9 l of water diffuses through (primarily) aquaporin-1 (AQP1) channels in the human choroid plexus, into the cerebrospinal fluid of the brain ventricles and spinal cord central canal, through the ependymal cell lining, and into the parenchyma of the CNS. Additional water is also derived from metabolism of glucose within the
J E, Rash +3 more
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Ecotoxicology and Environmental Safety, 2022 1,2-Dichloroethane (1,2-DCE) is a pervasive environmental pollutant, and overexposure to this hazardous material causes brain edema and demyelination in humans. We found that 1,2-DCE inhibits aquaporin 4 (AQP4) and is a primary pathogenic effector of 1,2-
Yizhou Zhong +14 more
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AQP4, Astrogenesis, and Hydrocephalus: A New Neurological Perspective
International Journal of Molecular Sciences, 2022 Aquaporin 4 (AQP4) is a cerebral glial marker that labels ependymal cells and astrocytes’ endfeet and is the main water channel responsible for the parenchymal fluid balance. However, in brain development, AQP4 is a marker of glial stem cells and plays a crucial role in the pathophysiology of pediatric hydrocephalus.
Leandro Castañeyra-Ruiz +5 more
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An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment. [PDF]
PLoS ONE, 2012 Aquaporin-4 (AQP4), the main water channel of the brain, is highly expressed in animal glioma and human glioblastoma in situ. In contrast, most cultivated glioma cell lines don't express AQP4, and primary cell cultures of human glioblastoma lose it ...
Susan Noell +4 more
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Cells, 2023 We assessed interactions between the astrocytic volume-regulated anion channel (VRAC) and aquaporin 4 (AQP4) in the supraoptic nucleus (SON). Acute SON slices and cultures of hypothalamic astrocytes prepared from rats received hyposmotic challenge (HOC ...
Yang Liu +11 more
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