Results 71 to 80 of about 24,501 (255)
, 2013 Wild type C57BL/6 mice were immunized with full length AQP4/CFA as described in Materials and Methods. Unimmunized mice or mice immunized with MOG35–55/CFA were used as controls.
Bernhard Hemmer (233893) +7 more
core +1 more source
Journal of Neuroinflammation, 2010 Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
Jarius Sven +10 more
doaj +1 more source
The effect of aquaporin-4 mis-localization on Aβ deposition in mice
Neurobiology of Disease, 2023 The reduced clearance of amyloid-β (Aβ) is thought to contribute to the development of the pathology associated with Alzheimer's disease (AD), which is characterized by the deposition of Aβ plaques.
Taylor J. Pedersen +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab +19 more
wiley +1 more source
, 2021 The graph represents the standard curve obtained with the ELISA kit (A). The table indicates the type of sample, the mean AQP4 concentration per group including all analyzed samples (central column), the mean AQP4 concentration when only the samples with
Maria Bernal (11512738) +11 more
core +1 more source
Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4:A study with an isoform-selective AQP4 inhibitor [PDF]
, 2020 The mammalian brain consists of 80% water, which is continuously shifted between different compartments and cellular structures by mechanisms that are, to a large extent, unresolved.
Khandelia, Himanshu +12 more
core +1 more source
Immunodominant T cell determinants of aquaporin-4, the autoantigen associated with neuromyelitis optica. [PDF]
PLoS ONE, 2010 Autoantibodies that target the water channel aquaporin-4 (AQP4) in neuromyelitis optica (NMO) are IgG1, a T cell-dependent Ig subclass. However, a role for AQP4-specific T cells in this CNS inflammatory disease is not known.
Patricia A Nelson +8 more
doaj +1 more source
Reactivity to AQP4 epitopes in relapsing–remitting multiple sclerosis [PDF]
Journal of Neuroimmunology, 2013 Autoantibodies against the water channel AQP4, expressed predominately in central nervous system astrocytes, are markers and pathogenic factors in Devic's disease. In this study we examined whether Multiple Sclerosis (MS) patients recognize antigenic epitopes on AQP4 that may define distinct disease subsets.
Alexopoulos, H. +6 more
openaire +4 more sources
Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui +10 more
wiley +1 more source
Aquaporin-4 antibody testing: direct comparison of M1-AQP4-DNA-transfected cells with leaky scanning versus M23-AQP4-DNA-transfected cells as antigenic substrate [PDF]
, 2014 Background: Neuromyelitis optica (NMO, Devic syndrome) is associated with antibodies to aquaporin-4 (NMO-IgG/AQP4-Ab) in the majority of cases. NMO-IgG/AQP4-Ab seropositivity in patients with NMO and its spectrum disorders has important differential ...
Jarius, Sven +9 more
core +3 more sources