Results 91 to 100 of about 23,657 (257)

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain

Cerebrospinal Fluid Research, 2010
Background The water channel protein aquaporin-4 (AQP4) is reported to be of possible major importance for accessory cerebrospinal fluid (CSF) circulation pathways.
Praetorius Jeppe, Søgaard Lise V, Rowland Ian J, Skjolding Anders D, Penkowa Milena, Juhler Marianne   +5 more
doaj   +1 more source

Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma

Annals of Medicine
Aquaporin 4 (AQP4) is abundant in the human brain and has an important role in brain homeostasis and diseases. AQP4 expression has been found to be associated with glioma malignancies.
Yu-Long Lan, Shuang Zou, Ruoli Chen
doaj   +1 more source

AQP4 autoantibodies in patients with idiopathic normal pressure hydrocephalus

, 2020
Idiopathic normal pressure hydrocephalus (iNPH) is a common neurological disorder with unknown etiology. A selective depletion of aquaporin 4 (AQP4) has been shown in iNPH patients.
Claudio P., Giorgia C., Elisabetta Z., Anna Pichiecchio., Gastaldi M., Diego F., Roberta Z., Markus R., Brigida M., Sven J., Massimiliano T., Silvia S.   +11 more
core   +1 more source

AQP4 NMD screen results.

, 2021
Ranking, average log2 enrichments and false discovery rates for each gene in the AQP4 NMD screen, as computed by MAGeCK. (TXT)
Rachel Green (2365774), Niladri K. Sinha (11581635), Benjamin Koleske (11581641), Syed Usman Enam (11581638), Boris Zinshteyn (440253)   +4 more
core   +1 more source

Clearance of activity-evoked K⁺ transients and associated glia cell swelling occur independently of AQP4:A study with an isoform-selective AQP4 inhibitor [PDF]

, 2020
The mammalian brain consists of 80% water, which is continuously shifted between different compartments and cellular structures by mechanisms that are, to a large extent, unresolved.
Khandelia, Himanshu, Himanshu Khandelia, Toft-Bertelsen, Trine Lisberg, MacAulay, Nanna, Helle S. Waagepetersen, Khandelia, Himanshu; id_orcid, Christensen, Sofie Kjellerup, Nanna MacAulay, Sofie Kjellerup Christensen, Trine Lisberg Toft‐Bertelsen, Brian Roland Larsen, Waagepetersen, Helle S., Larsen, Brian Roland   +12 more
core   +1 more source

Effects of erythropoietin and methylprednisolone on AQP4 expression in astrocytes

Molecular Medicine Reports, 2017
Methylprednisolone sodium succinate (MPSS) has been suggested as a treatment for spinal cord injury (SCI), but its use has been limited due to its adverse effects. Erythropoietin (EPO) has been suggested as a promising candidate for limiting SCI in mammals.
Wang, Changchao, Xu, Youjia, Huang, Yadong, Huang, Yan   +3 more
openaire   +3 more sources

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Nissl’s staining of AQP4^+/+ and AQP4^−/− mice.

, 2013
Injection of rhVEGF165 intracerebroventricularly had no effect on Nissl’s staining in normal mice. At the three time points, marked neuron loss perihemotoma were found in AQP4−/− mice when compared to AQP4+/+ mice.
Yuping Tang (249674), Qiang Dong (380835), Heling Chu (425189)   +2 more
core   +1 more source

TH/TRs–COL11A2 Axis Mediates Loss of a Differentiated Astrocyte State in Hypogyrified Brains

Advanced Science, EarlyView.
Using a gyrencephalic congenital hypothyroidism pig model, this study reveals cerebral atrophy and cortical hypogyrification. Single‐cell sequencing identifies astrocytes as major TH‐responsive cells, with the COL11A2‐enriched Astro‐2 state nearly absent.
Ying Zhang, Xiao Wang, Hongyan Ma, Pengcheng Lyu, Shuangjie Tian, Ruojun Zong, Jiani Chen, Gang Ren, Yongjiang Yang, Zichen Yang, Guosong Qin, Naishi Li, Yanfang Wang, Jianwei Jiao, Jianguo Zhao   +14 more
wiley   +1 more source