Results 91 to 100 of about 24,501 (255)

Overlapping AQP4 peptides.

, 2013
Overlapping AQP4 peptides.
Bernhard Hemmer (233893), Sudhakar Reddy Kalluri (357524), Marco Prinz (69460), Thomas Korn (220026), Rajneesh Srivastava (143651), Ori Staszewski (357526), Franziska Petermann (220017), Veit Rothhammer (357525)   +7 more
core   +1 more source

Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain

ASN Neuro, 2015
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the central nervous system. Expression is particularly high around areas in contact with cerebrospinal fluid, suggesting that AQP4 plays a role in fluid exchange ...
Jacqueline A. Hubbard, Mike S. Hsu, Marcus M. Seldin, Devin K. Binder   +3 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

AQP4 abundance.

, 2015
Semiquantitative immunoblotting of kidney protein prepared from inner medulla. Immunoblot was reacted with anti-AQP4 antibody and reveals a single ~ 34.5 kDa AQP4-band (A-E). Data are presented in Table 10.
Sophie Constantin Lütken (689916), Jørgen Frøkiær (463157), Søren Nielsen (155815)   +2 more
core   +1 more source

Update on the intriguing roles of AQP4 expression and redistribution in the progression and treatment of glioma

Annals of Medicine
Aquaporin 4 (AQP4) is abundant in the human brain and has an important role in brain homeostasis and diseases. AQP4 expression has been found to be associated with glioma malignancies.
Yu-Long Lan, Shuang Zou, Ruoli Chen
doaj   +1 more source

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

Alterations of average pRNFL thickness and segmented macular volume 0–6 months after initial ON attack in AQP4-Ab-positive ON and AQP4-Ab-negative ON eyes.

, 2016
The images of segmented macular layers were scanned by OCT. The upper image of Fig 2A shows segmented retina layers around the optic disc, and the region between red and green lines shows pRNFL.
Huanfen Zhou (2852270), Shihui Wei (580991), Hongyang Li (296731), Quangang Xu (114116), Chunxia Peng (2634328), Mo Yang (507360), Wei Wang (17594), Shuo Zhao (1545043), Shanshan Cao (2852267)   +8 more
core   +1 more source

The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A

Frontiers in Neuroscience, 2019
Spinal cord edema, mainly including vasogenic and cytotoxic edema, influences neurological outcome after spinal cord contusion (SCC). Aquaporin 4 (AQP4) is the most ubiquitous water channel in the central nervous system (CNS), which is a rate-limiting ...
Yuan Huang, Sheng-nan Li, Xiu-ya Zhou, Li-xin Zhang, Gang-xian Chen, Ting-hua Wang, Ting-hua Wang, Qing-jie Xia, Nan Liang, Xiao Zhang   +9 more
doaj   +1 more source

AQP4 and AQP4‐IgG in NMO

, 2013
The water channel aquaporin-4 (AQP4) is the target of the immunoglobulin G autoantibody (AQP4-IgG) in neuromyelitis optica (NMO). AQP4 is expressed in foot processes of astrocytes throughout the central nervous system, as well as in skeletal muscle and epithelial cells in kidney, lung and gastrointestinal organs.
Verkman, AS, Phuan, Puay‐Wah, Asavapanumas, Nithi, Tradtrantip, Lukmanee   +3 more
openaire   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source