Results 81 to 90 of about 23,657 (257)

BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex

Scientific Reports, 2021
Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB).
Kazuya Morita, Naoyuki Matsumoto, Kengo Saito, Toshihide Hamabe-Horiike, Keishi Mizuguchi, Yohei Shinmyo, Hiroshi Kawasaki   +6 more
doaj   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Aquaporin-4 autoantibodies in Neuromyelitis Optica: AQP4 isoform-dependent sensitivity and specificity. [PDF]

PLoS ONE, 2013
Neuromyelitis Optica (NMO) is an autoimmune demyelinating disease, characterized by the presence of autoantibody (NMO-IgG) to Aquaporin-4 (AQP4). NMO-IgG identification supports NMO diagnosis and several diagnostic tests have been developed, but their ...
Francesco Pisani, Angelo Sparaneo, Carla Tortorella, Maddalena Ruggieri, Maria Trojano, Maria Grazia Mola, Grazia Paola Nicchia, Antonio Frigeri, Maria Svelto   +8 more
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Aquaporin-4 deficiency induced white matter injury via upregulated complement component 3 in cerebral small vessel disease

Journal of Neuroinflammation
Background Cerebral small vessel disease (CSVD) is the most common neurological disorder associated with a high incidence of stroke and dementia. For the heterogeneity of the pathogenesis, effective preventive and therapeutic strategies remain limited ...
Yun Chen, Lingling Jiang, Dongxiao Yao, Dandan Liu, Yuesong Pan, Yilong Wang   +5 more
doaj   +1 more source

B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 [PDF]

Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which the water-channel protein AQP4 is the target antigen1. The immunopathology in neuromyelitis optica is largely driven by autoantibodies to AQP42.
Ulianov, Oleksii, Buchholz, Veit R, Jarosch, Sebastian, Petrozziello, Elisabetta, Ottersen, Ole Petter, Korn, Thomas, Lammens, Katja, Böttcher, Jan P., Buettner, Andreas, Grassmann, Simon, Ollinger, Rupert, Mühlbauer, Anton, Busch, Dirk H, Boettcher, Jan P., Busch, Dirk H., Klein, Ludger, Muehlbauer, Anton, Muschaweckh, Andreas, Pfaller, Monika, Heink, Sylvia, Kalluri, Sudhakar Reddy, Tyystjaervi, Sofia, Seyhan, Gonul, Büttner, Andreas, Böttcher, Jan P, Delbridge, Claire, Afzali, Ali Maisam, Steiger, Katja, Sie, Christopher, Schmidt Supprian, Marc, Kreutzfeldt, Mario, Merkler, Doron, Chen, Hsin Hsiang, Nirschl, Lucy, Straub, Adrian, Rad, Roland, Pardas, Irene Bonafonte, Federle, Christine, Supprian, Marc Schmidt, Tyystjärvi, Sofia, Hassler, Tobias, Wagner, Ingrid, Buchholz, Veit R., Hemmer, Bernhard   +43 more
core   +1 more source

Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain

ASN Neuro, 2015
Aquaporin-4 (AQP4) is a bidirectional water channel that is found on astrocytes throughout the central nervous system. Expression is particularly high around areas in contact with cerebrospinal fluid, suggesting that AQP4 plays a role in fluid exchange ...
Jacqueline A. Hubbard, Mike S. Hsu, Marcus M. Seldin, Devin K. Binder   +3 more
doaj   +1 more source

The Dual Role of AQP4 in Cytotoxic and Vasogenic Edema Following Spinal Cord Contusion and Its Possible Association With Energy Metabolism via COX5A

Frontiers in Neuroscience, 2019
Spinal cord edema, mainly including vasogenic and cytotoxic edema, influences neurological outcome after spinal cord contusion (SCC). Aquaporin 4 (AQP4) is the most ubiquitous water channel in the central nervous system (CNS), which is a rate-limiting ...
Yuan Huang, Sheng-nan Li, Xiu-ya Zhou, Li-xin Zhang, Gang-xian Chen, Ting-hua Wang, Ting-hua Wang, Qing-jie Xia, Nan Liang, Xiao Zhang   +9 more
doaj   +1 more source

Western blot analysis of AQP4 protein expression in each normal AQP4^+/+ group.

, 2013
(A, B) Western blot analysis showed rhVEGF165 injected intracerebroventricularly up-regulated AQP4 protein expression at striatum in normal AQP4+/+ mice at 1 d, 3 d, and 7 d (n = 6 ...
Yuping Tang (249674), Qiang Dong (380835), Heling Chu (425189)   +2 more
core   +1 more source