Results 81 to 90 of about 24,501 (255)

Aquaporin-4 protein expression in normal canine brains

BMC Veterinary Research, 2021
Background Aquaporin-4 (AQP4) is in growing recognition as potential marker for cancer progression, differentiation and therapeutic intervention. No information is available about AQP4 expression in the normal canine brain.
Patricia Álvarez, Ester Blasco, Martí Pumarola, Annette Wessmann   +3 more
doaj   +1 more source

BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex

Scientific Reports, 2021
Aquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB).
Kazuya Morita, Naoyuki Matsumoto, Kengo Saito, Toshihide Hamabe-Horiike, Keishi Mizuguchi, Yohei Shinmyo, Hiroshi Kawasaki   +6 more
doaj   +1 more source

Utility of the APE2 Score as a Diagnostic Tool for Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To retrospectively evaluate the diagnostic performance of the Antibody Prevalence in Epilepsy and Encephalopathy (APE2) score relative to clinician‐adjudicated autoimmune encephalitis (AE) and the Graus criteria in a tertiary neuroimmunology referral cohort, including antibody‐negative AE.
Bijoya Basu, Sophia F. Damman, Samhitha M. Rai, Hesham Abboud   +3 more
wiley   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

NMO-IgG staining patterns in AQP4-EmGFP versus AQP4 expressing cells.

, 2013
Fusion of EmGFP to AQP4 molecules has no effect on the formation of the different staining patterns of NMO-IgG in M-1 and M-23 AQP4 transfected cells. NMO-IgG has the same laminar staining pattern when binding M-23 AQP4 with and without EmGFP fusion (A).
Bettina Kuenz (89551), Fahmy Aboul-Enein (351477), Franziska Di Pauli (365013), Sven Jarius (25658), Maria K. Storch (365016), Wolfgang Kristoferitsch (351482), Markus Reindl (89559), Andreas Lutterotti (89552), Thomas Berger (72614), Simone Mader (365012), Michael Khalil (365015), Kathrin Schanda (365014)   +11 more
core   +1 more source

Quantification and spatial comparisons of pRNFL and segmented macular layers in AQP4-Ab-positive ON and AQP4-Ab-negative ON eyes without an ON attack for 6 months.

, 2016
Fig 3. Analysis of pRNFL thickness and segmented macular layer volume. Fig 3A, 3B and 3C show the statistical results of average pRNFL thickness, GCIP volume and INL volume, when controlling BCVA, inter-eye correlation, episodes of ON attack and disease ...
Huanfen Zhou (2852270), Shihui Wei (580991), Hongyang Li (296731), Quangang Xu (114116), Chunxia Peng (2634328), Mo Yang (507360), Wei Wang (17594), Shuo Zhao (1545043), Shanshan Cao (2852267)   +8 more
core   +1 more source

Efficacy of Fampridine on Refractory Optic Neuritis in Neuromyelitis Optica Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorders (NMOSD) usually occur with acute refractory optic neuritis (ON). However, there is a lack of efficacious treatments to improve recovery. Since fampridine has been found to improve the prognosis of multiple sclerosis (MS) and MS‐related ON, it is necessary to explore the efficacy of fampridine ...
Hongxuan Wang, Wanru Chen, Xiangpen Li, Hengjian Lu, Chenguang Li, Xiaoni Zhang, Lulu Bu, Xiaoyu Xu, Qingyu Shen, Ying Peng   +9 more
wiley   +1 more source

Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain

Cerebrospinal Fluid Research, 2010
Background The water channel protein aquaporin-4 (AQP4) is reported to be of possible major importance for accessory cerebrospinal fluid (CSF) circulation pathways.
Praetorius Jeppe, Søgaard Lise V, Rowland Ian J, Skjolding Anders D, Penkowa Milena, Juhler Marianne   +5 more
doaj   +1 more source

Effects of erythropoietin and methylprednisolone on AQP4 expression in astrocytes

Molecular Medicine Reports, 2017
Methylprednisolone sodium succinate (MPSS) has been suggested as a treatment for spinal cord injury (SCI), but its use has been limited due to its adverse effects. Erythropoietin (EPO) has been suggested as a promising candidate for limiting SCI in mammals.
Wang, Changchao, Xu, Youjia, Huang, Yadong, Huang, Yan   +3 more
openaire   +3 more sources

Serostatus‐Specific Prognostic Profiles and Phenotype‐Dependent Therapeutic Windows in Autoimmune Encephalitis: A Multicenter Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background While autoimmune encephalitis (AE) outcomes vary, serostatus‐specific prognostic determinants and institutional clustering effects remain poorly characterized. We aimed to delineate the distinct prognostic architecture of AE, identifying serostatus‐specific risk factors and potential therapeutic windows.
Xiaohong Tang, Jingxian Wang, Kaixin Zhu, Zhen Zhang, Liao Wu, Wei Wang, Chang Li, Qingyun Li, Hao Li, Jinghua Chen, Zhangxu Lian, Bin Liu, Tengfei Liu, Chunmei Wen, Nuan Wang, Sen Qun, Lishun Xiao, Qingwei Lai   +17 more
wiley   +1 more source