Results 61 to 70 of about 24,501 (255)

The Structure of AQP4 and Its Relationship to Disease

The FASEB Journal, 2021
Aquaporin‐4 (AQP4) is the most common water channel protein in the central nervous system (Flippidis, Carozza, & Rekate, 2016). It is highly concentrated in the cell membrane of the astrocytic endfeet, which form the blood‐brain barrier (BBB) and help protect the brain from toxins (Mader & Brimberg, 2019; Woodruff & Götz, 2018).
Koyuki Yamada, Ishani Pidara
openaire   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Effects of AQP4 and KCNJ10 Gene Polymorphisms on Drug Resistance and Seizure Susceptibility in Chinese Han Patients with Focal Epilepsy

Neuropsychiatric Disease and Treatment, 2020
Haoyue Zhu, Mengqi Zhang, Yujiao Fu, Hongyu Long, Wenbiao Xiao, Li Feng, Bo Xiao, Luo Zhou Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Luo ZhouDepartment of ...
Zhu H, Zhang M, Fu Y, Long H, Xiao W, Feng L, Xiao B, Zhou L   +7 more
doaj  

AQP4 knockout promotes neurite outgrowth via upregulating GAP43 expression in infant rats with hypoxic‐ischemic brain injury

Ibrain, 2022
Neonatal hypoxic‐ischemic encephalopathy (NHIE) induces severe cerebral damage and neurological dysfunction, with seldom effective therapy. Aquaporin‐4 (AQP4) is involved in aggravating brain damage induced by NHIE.
Qi‐Qin Dan, Zheng Ma, Ya‐Xin Tan, Belegu Visar, Li Chen   +4 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Changes in sensitivity of the CBE test using cells transfected with different AQP4 isoforms.

, 2013
Immunofluorescence analysis performed using NMO sera (NMO) and AQP4 commercial antibodies (AQP4) on cells transfected with AQP4-M23 (M23), WT AQP4-M1 (M1) and the mutated form of AQP4-M1 (M1M23I).
Angelo Sparaneo (387329), Maddalena Ruggieri (485748), Maria Grazia Mola (387330), Maria Trojano (301639), Carla Tortorella (301673), Antonio Frigeri (352675), Francesco Pisani (387328), Grazia Paola Nicchia (352672), Maria Svelto (330761)   +8 more
core   +1 more source

Aquaporin-4 deficiency induced white matter injury via upregulated complement component 3 in cerebral small vessel disease

Journal of Neuroinflammation
Background Cerebral small vessel disease (CSVD) is the most common neurological disorder associated with a high incidence of stroke and dementia. For the heterogeneity of the pathogenesis, effective preventive and therapeutic strategies remain limited ...
Yun Chen, Lingling Jiang, Dongxiao Yao, Dandan Liu, Yuesong Pan, Yilong Wang   +5 more
doaj   +1 more source

Structural Alterations of Segmented Macular Inner Layers in Aquaporin4-Antibody-Positive Optic Neuritis Patients in a Chinese Population. [PDF]

PLoS ONE, 2016
This study aimed to analyse the structural injury of the peripapillary retinal nerve fibre layer (pRNFL) and segmented macular layers in optic neuritis (ON) in aquaporin4-antibody (AQP4-Ab) seropositivity(AQP4-Ab-positiveON) patients and in AQP4-Ab ...
Chunxia Peng, Wei Wang, Quangang Xu, Shuo Zhao, Hongyang Li, Mo Yang, Shanshan Cao, Huanfen Zhou, Shihui Wei   +8 more
doaj   +1 more source

Role of AQP4 in skeletal muscle

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2018
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Frigeri, Antonio, Paola, Nicchia G
openaire   +3 more sources

“Low‐Positive” MOG‐IgG Cases Among Adults With a First Event Suggestive of Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum collected ≤ 6 months from the FDE.
Javier Villacieros‐Álvarez, Carmen Espejo, Georgina Arrambide, Mireia Castillo, Marta Rodriguez, Helena Ariño, Iker Elosua, Carmen Tur, Angela Vidal‐Jordana, Andreu Vilaseca, Joaquín Castilló, Ingrid Galán, Luciana Midaglia, Carlos Nos, Breogan Rodríguez‐Acevedo, Ana Zabalza, Luca Bollo, Agustín Pappolla, René Carvajal, Neus Mongay‐Ochoa, Jordi Rio, Jaume Sastre‐Garriga, Manuel Comabella, Gesualdina Busiello, Sofia Sceppacuercia, Àlex Rovira, Xavier Montalban, Mar Tintoré, Cristina Auger, Álvaro Cobo‐Calvo   +29 more
wiley   +1 more source