Results 61 to 70 of about 23,657 (257)

NMO-IgG staining patterns in AQP4-EmGFP versus AQP4 expressing cells.

, 2013
Fusion of EmGFP to AQP4 molecules has no effect on the formation of the different staining patterns of NMO-IgG in M-1 and M-23 AQP4 transfected cells. NMO-IgG has the same laminar staining pattern when binding M-23 AQP4 with and without EmGFP fusion (A).
Bettina Kuenz (89551), Fahmy Aboul-Enein (351477), Franziska Di Pauli (365013), Sven Jarius (25658), Maria K. Storch (365016), Wolfgang Kristoferitsch (351482), Markus Reindl (89559), Andreas Lutterotti (89552), Thomas Berger (72614), Simone Mader (365012), Michael Khalil (365015), Kathrin Schanda (365014)   +11 more
core   +1 more source

Aquaporin4 (AQP4) in brain disorder

Folia Pharmacologica Japonica, 2019
Two third of our body is composed of water molecules. Regulation of water and electrolytes is indeed the most important homeostatic functions. Many diseases, such as heart failure, are associated with disturbance in fluid homeostasis. Surprisingly, water dynamics inside the brain is still largely unknown.
openaire   +3 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

AQP4 knockout promotes neurite outgrowth via upregulating GAP43 expression in infant rats with hypoxic‐ischemic brain injury

Ibrain, 2022
Neonatal hypoxic‐ischemic encephalopathy (NHIE) induces severe cerebral damage and neurological dysfunction, with seldom effective therapy. Aquaporin‐4 (AQP4) is involved in aggravating brain damage induced by NHIE.
Qi‐Qin Dan, Zheng Ma, Ya‐Xin Tan, Belegu Visar, Li Chen   +4 more
doaj   +1 more source

The Structure of AQP4 and Its Relationship to Disease

The FASEB Journal, 2021
Aquaporin‐4 (AQP4) is the most common water channel protein in the central nervous system (Flippidis, Carozza, & Rekate, 2016). It is highly concentrated in the cell membrane of the astrocytic endfeet, which form the blood‐brain barrier (BBB) and help protect the brain from toxins (Mader & Brimberg, 2019; Woodruff & Götz, 2018).
Koyuki Yamada, Ishani Pidara
openaire   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance

Journal of Neuroinflammation, 2010
Background In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
Jarius Sven, Franciotta Diego, Paul Friedemann, Ruprecht Klemens, Bergamaschi Roberto, Rommer Paulus S, Reuss Reinhard, Probst Christian, Kristoferitsch Wolfgang, Wandinger Klaus, Wildemann Brigitte   +10 more
doaj   +1 more source

Structural Alterations of Segmented Macular Inner Layers in Aquaporin4-Antibody-Positive Optic Neuritis Patients in a Chinese Population. [PDF]

PLoS ONE, 2016
This study aimed to analyse the structural injury of the peripapillary retinal nerve fibre layer (pRNFL) and segmented macular layers in optic neuritis (ON) in aquaporin4-antibody (AQP4-Ab) seropositivity(AQP4-Ab-positiveON) patients and in AQP4-Ab ...
Chunxia Peng, Wei Wang, Quangang Xu, Shuo Zhao, Hongyang Li, Mo Yang, Shanshan Cao, Huanfen Zhou, Shihui Wei   +8 more
doaj   +1 more source

The effect of aquaporin-4 mis-localization on Aβ deposition in mice

Neurobiology of Disease, 2023
The reduced clearance of amyloid-β (Aβ) is thought to contribute to the development of the pathology associated with Alzheimer's disease (AD), which is characterized by the deposition of Aβ plaques.
Taylor J. Pedersen, Samantha A. Keil, Warren Han, Marie X. Wang, Jeffrey J. Iliff   +4 more
doaj   +1 more source

Opsoclonus‐Myoclonus‐Ataxia Revealing Underlying Neuromyelitis Optica Spectrum Disorder [PDF]

Mov Disord Clin Pract
Movement Disorders Clinical Practice, EarlyView.
Verde A, de Paiva Santos Rolim F, Catunda A, Filho J, Pitombeira M, Carvalho F, de Assis Pereira Matos P.   +6 more
europepmc   +2 more sources