Results 101 to 110 of about 18,179 (218)

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source

Distinct cerebrospinal fluid profiles of astrocytic aquaporin-4 and GFAP in neuroinflammatory disorders

Neurobiology of Disease
Aquaporin 4 (AQP4), a water channel expressed in astrocytic end feet forming the blood brain barrier, is predominantly expressed in the central nervous system.
Steffen Halbgebauer, Niklas Winger, Zeynep Elmas, Badrieh Fazeli, Franziska Bachhuber, Deborah K. Erhart, Önder Soylu, Paula Klassen, Makbule Senel, Johannes Dorst, Karl Georg Haeusler, Jochen Weishaupt, Markus Otto, Hayrettin Tumani   +13 more
doaj   +1 more source

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

The Journal of Physiology, EarlyView.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos, Denis E. Bragin, Nagesh C. Shanbhag, Luise Schlotterose, Mootaz M. Salman   +4 more
wiley   +1 more source

Sueño, adicciones y AQP4

Revista de la Facultad de Medicina
La reflexión en el ámbito médico permite analizar y comprender las experiencias clínicas y personales, favoreciendo el aprendizaje continuo y el desarrollo profesional. “Despertar” implica tomar conciencia de los retos y oportunidades que se presentan día a día, tanto en la formación académica como en la práctica clínica.
openaire   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Regulates Competition Dependent Astrocyte Morphogenesis and Tiling in Murine Cortex

Glia, Volume 74, Issue 8, August 2026.
Neuronal contact‐induced expression of S1PR1 in astrocytes is regulated by JAK‐STAT3 signaling. Astrocytic S1PR1 modulates cortical astrocyte morphogenesis. Astrocytic S1PR1 regulates astrocyte territorial overlap/tiling in a competition dependent manner.
Jean Patrick M. Gonzales, Connor Tuck, Surya Chandra Rao Thumu, Soha Munir, Jaden Harris, Hunain (Zeik) Tariq, Paul Marcelli, Oscar Dominguez, Kaviya Suriyakumar Anbazagan, Sandeep K. Singh   +9 more
wiley   +1 more source

Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes

Glia, Volume 74, Issue 8, August 2026.
Cerebellar Olig2 positive astrocytes are most abundant in the cerebellar nuclei. Cerebellar astrocytes expressing Olig2 have unique gene expression profiles. Yin Yang 1 specifically supports the development of astrocytes expressing Olig2. Deletion of YY1 during development increases numbers of astrocytes expressing Olig2 but hinders their ...
Masoumeh Zarei‐Kheirabadi, Katarzyna M. Tyc, Lauren Dain, Maryam Ashrafi Kheirabadi, Jennifer Hanco, Karli Mockenhaupt, Soha Munir, Adam McQuiston, Sandeep K. Singh, Tomasz Kordula   +9 more
wiley   +1 more source

表达AQP4不同亚型的细胞系检测AQP4抗体敏感性的研究

Zhongshan Daxue xuebao. Yixue kexue ban, 2012
【目的】 研究表达不同亚型的AQP4细胞系检测中国人群视神经脊髓炎患者血清中AQP4抗体的敏感性? 【方法】 根据纳入标准共获取血清205例,其中包括视神经脊髓炎40例,长节段性脊髓炎39例,复发性视神经炎39例,多发性硬化47例,另设40例健康对照?使用稳定表达水通道蛋白4的四种细胞系HEK293/pcDNA3.1(+)-M23-AQP4?HEK293/pcDNA3.1(+)-M1-AQP4、HEK293/pEGFP-N3-M23-AQP4?HEK293/pEGFP-N3-M1 ...
doaj  

AQP4 and HIVAN

Experimental and Molecular Pathology, 2018
Fahad, Mubariz, Joseph L, Bryant, Vamshi K C, Nimmagadda, Jayanta, Ray, Tapas K, Makar   +4 more
openaire   +2 more sources

A Rare Overlap of AQP4 and MOG Seropositivity in Neuromyelitis Optica Spectrum Disorder: A Case Report

Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is an immune‐mediated disorder of the central nervous system associated with autoantibodies against aquaporin‐4 (AQP4). This is distinct from myelin‐oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), defined by anti‐MOG antibodies.
Sarah E. Butler, Siew Kar Chen, Mastura Monif   +2 more
wiley   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source