Results 121 to 130 of about 24,501 (255)

The Functional Interaction of KATP and BK Channels with Aquaporin-4 in the U87 Glioblastoma Cell

Biomedicines
K+ channels do play a role in cell shape changes observed during cell proliferation and apoptosis. Research suggested that the dynamics of the aggregation of Aquaporin-4 (AQP4) into AQP4-OAP isoforms can trigger cell shape changes in malignant glioma ...
Fatima Maqoud, Laura Simone, Domenico Tricarico, Giulia Maria Camerino, Marina Antonacci, Grazia Paola Nicchia   +5 more
doaj   +1 more source

Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease

Cell Reports, 2019
Summary: Astrocytes constantly adapt their ramified morphology in order to support brain cell assemblies. Such plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4 (AQP4).
Silvia Ciappelloni, Delphine Bouchet, Nadège Dubourdieu, Eric Boué-Grabot, Blanka Kellermayer, Constance Manso, Romain Marignier, Stéphane H.R. Oliet, Thomas Tourdias, Laurent Groc   +9 more
doaj   +1 more source

Sueño, adicciones y AQP4

Revista de la Facultad de Medicina
La reflexión en el ámbito médico permite analizar y comprender las experiencias clínicas y personales, favoreciendo el aprendizaje continuo y el desarrollo profesional. “Despertar” implica tomar conciencia de los retos y oportunidades que se presentan día a día, tanto en la formación académica como en la práctica clínica.
openaire   +1 more source

Patient iPSC‐derived astrocytes reveal impaired homeostasis and reactive‐like features in propionic acidemia

The Journal of Pathology, EarlyView.
Abstract Propionic acidemia (PA) is a neurometabolic disorder caused by propionyl‐CoA carboxylase deficiency with frequent neurological involvement, yet cell‐type‐specific mechanisms remain poorly defined. We established human induced pluripotent stem cell (iPSC)‐derived astrocytes (iAs) from patients harboring PCCA or PCCB mutations and investigated ...
Irene González‐Garnacho, Mar Álvarez, Francisco Zafra, Pilar Rodríguez‐Pombo, Lourdes R Desviat, Eva Richard   +5 more
wiley   +1 more source

AQP3 and AQP4 are separated in post-Golgi carriers.

, 2013
Representative example of a single plane of a cell transiently expressing AQP3-IRES-EGFP and AQP4-IRES-EGFP labeled with antibodies towards AQP3 and AQP4, 10 minutes following release from a 19°C temperature block and inserts of the marked areas: arrows ...
Sabrina Sundbye (460017), Lene N. Nejsum (460018), Eva C. Arnspang (118878), W. James Nelson (160857)   +3 more
core   +1 more source

Distinct cerebrospinal fluid profiles of astrocytic aquaporin-4 and GFAP in neuroinflammatory disorders

Neurobiology of Disease
Aquaporin 4 (AQP4), a water channel expressed in astrocytic end feet forming the blood brain barrier, is predominantly expressed in the central nervous system.
Steffen Halbgebauer, Niklas Winger, Zeynep Elmas, Badrieh Fazeli, Franziska Bachhuber, Deborah K. Erhart, Önder Soylu, Paula Klassen, Makbule Senel, Johannes Dorst, Karl Georg Haeusler, Jochen Weishaupt, Markus Otto, Hayrettin Tumani   +13 more
doaj   +1 more source

Top‐Down CSF Peptidomics Reveals Disease‐Associated Peptide Signatures and Oxidative Modifications in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

PROTEOMICS, EarlyView.
ABSTRACT Multiple sclerosis and neuromyelitis optica spectrum disorder (NMOSD) are inflammatory demyelinating diseases of the CNS whose diagnosis is mainly based on clinical evidence, magnetic resonance imaging, and the analysis of cerebrospinal fluid (CSF). Current approaches provide only partial insight into disease‐related biological processes, thus
Cristina Contini, Lorena Lorefice, Greca Lai, Alessandra Schirru, Giorgia Zodio, Tiziana Cabras, Alessandra Olianas, Giacomo Diaz, Eleonora Cocco, Barbara Manconi   +9 more
wiley   +1 more source

Hinokitiol Promotes Neural Repair After Spinal Cord Injury by Reprogramming Microglial Inflammatory and Redox Responses

Phytotherapy Research, EarlyView.
Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang, Jing Wang, Tianyi Wang, Qihao Fu, Jiawen Xu, Chaochen Li, Zheng Zhou, Chenxi Zhang, Guanhua Xu, Mingjie Xia, Zhiming Cui   +10 more
wiley   +1 more source

Unaltered Glutamate Transporter-1 Protein Levels in Aquaporin-4 Knockout Mice

ASN Neuro, 2017
Maintenance of glutamate and water homeostasis in the brain is crucial to healthy brain activity. Astrocytic glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) are the main regulators of extracellular glutamate and osmolarity, respectively.
Jacqueline A. Hubbard, Devin K. Binder
doaj   +1 more source

Carbon dots as a smart nanoplatform for the blood‐brain barrier penetration and ischemic stroke therapy

Responsive Materials, EarlyView.
This review presents the structure and transport routes of the blood‐brain barrier, summarizes the ischemic stroke pathophysiological cascade, and discusses the BBB‐crossing mechanisms and multitarget therapeutic effects of carbon dots, demonstrating their promising theranostic potential for ischemic stroke.
Yanhan Huang, Xuan Hou, Haiping Zhao, Qi Kong, Xiayan Wang, Xiaokun Geng, Zaicheng Sun   +6 more
wiley   +1 more source