Results 111 to 120 of about 24,501 (255)

Binding of a recombinant monoclonal NMO-IgG to mouse AQP4.

, 2013
A. CHO cells expressing mouse M1 or M23 AQP4 were labeled with an anti-AQP4 C-terminus antibody (green) and recombinant monoclonal NMO antibody rAb-53 (labeled ‘NMO-IgG’, red). B.
A. S. Verkman (161048), Jeffrey L. Bennett (340202), Julien Ratelade (340201)   +2 more
core   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Neurological scores and Nissl’s staining cell counting of AQP4^+/+ and AQP4^−/− mice.

, 2013
(A) RhVEGF165 alleviated neurological deficits due to ICH of AQP4+/+ and AQP4−/− mice at 1 d, 3 d, and 7 d after injected intracerebroventricularly (n = 6 ...
Yuping Tang (249674), Qiang Dong (380835), Heling Chu (425189)   +2 more
core   +1 more source

Inner medullary expression of AQP4.

, 2015
Values are expressed as means ± SE. AQP4, aquaporin-4;n, number of rats.*P
Sophie Constantin Lütken (689916), Jørgen Frøkiær (463157), Søren Nielsen (155815)   +2 more
core   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes

, 2001
Aquaporin 4 (AQP4) is the predominant water channel in the brain. It is targeted to specific membrane domains of astrocytes and plays a crucial role in cerebral water balance in response to brain edema formation.
Madrid González, Ricardo, Merot, Jean, Benichou, Serge, Barrault, Marie-Benedicte, Le Maout, Sophie, Janvier, Katy, R. Madrid   +6 more
core   +1 more source

In Vivo Dynamic D2O‐MRI for Quantifying Apparent CSF Water Renewal Across Ventricular and Extraventricular Compartments

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The choroid plexus has long been regarded as the principal source of cerebrospinal fluid (CSF), yet this view remains unresolved. We developed a dynamic indirect D2O MRI approach to quantify regional apparent CSF water renewal in vivo in rats at 9.4 T.
Zhao Zhang, Yun Wu, Yanmin Zheng, Zhuoyang Lin, Ye Li, Qiong Ye   +5 more
wiley   +1 more source

AQP4 role in renal K+ transport

The FASEB Journal, 2009
The collecting duct principle cells (PC) play a major role for concentration of urine and regulation of K+ homeostasis. Two water channels, AQP3 and AQP4, are expressed in the PC basolateral membrane (BLM). Here we present evidence that AQP4 participates in regulation of renal K+ transport.
Sergey Zelenin, Marina Zelenina, Yanhong Li, Padideh Kamali‐Zare, Alexander Bondar, Hjalmar Brismar, Anita Aperia   +6 more
openaire   +1 more source

Accelerated Motion‐Compensated Diffusion‐Weighted pCASL Using Subspace Low‐Rank Reconstruction for Quantification of BBB Water Exchange and Permeability

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop an accelerated motion‐compensated diffusion‐weighted pseudo‐continuous arterial spin labeling (MCDW‐pCASL) method using a spatial subspace low‐rank reconstruction method for efficient quantification of blood–brain barrier (BBB) water exchange (kw) and permeability (PSw).
Zixuan Liu, Chenyang Zhao, Ziyang Huang, Fanhua Guo, Danny J. J. Wang, Xingfeng Shao   +5 more
wiley   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source