Results 131 to 140 of about 18,317 (228)

X‐Linked USP11 Drives Depression‐Like Behaviors by Stabilizing CK2α and Disrupting Mitochondrial Function

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
This study reveals that USP11 mediates depressive‐like behaviors and mitochondrial dysfunction in the prefrontal cortex. Mechanistically, USP11 directly binds to and deubiquitinates CK2α, thereby stabilizing its protein level and promoting mitochondrial impairment.
Yuqi Feng, Ningyuan Li, Lingfeng Zhang, Wei Wang, Hao Duan, Siqi Sun, Ruiling Li, Yuhui Zhang, Xinhua Song, Yingyue Zhang, Honghan Zhang, Zhaowen Nie, Hanchun Yan, Chao Wang, Zhongchun Liu   +14 more
wiley   +1 more source

Unmet needs in the care of patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody associated disease: insights from Germany. [PDF]

Neurol Res Pract
Giglhuber K, Bertrand A, Zappe C, Kleiter I, Ayzenberg I, Berthele A, Neuromyelitis Optica Study Group (NEMOS).   +6 more
europepmc   +1 more source

Synergistic Interaction Between MALAT1/miR‐30b‐5p/BAFF Axis and Inflammatory Cytokines Underlies Rituximab‐Refractory NMOSD

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
The MALAT1/miR‐30b‐5p/BAFF axis is activated in monocytes during NMOSD onset and relapse. The MALAT1/miR‐30b‐5p/BAFF axis is activated in monocytes, thereby facilitating the release of BAFF and inflammatory cytokines (including IL‐1, IL‐6, IL‐8, and TNF‐α).
Meiqun Deng, Keyi Zeng, Wei Chen, Jing Chen, Xiaoting Lin, Lei Chen, Yuxin Yao, Hanfei Chen, Aiyu Lin   +8 more
wiley   +1 more source

Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets. [PDF]

Mol Biomed
Wang NN, Liu ZJ, Wang Y, Cao F, Xu D.
europepmc   +1 more source

Single‐Nucleus RNA‐Seq Reveals Neuroprotective Effects of Acupuncture in Chronic Migraine Through Modulation of Glial Subtypes

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Acupuncture Alleviates Chronic Migraine by Reprogramming Glial Cells and Restoring Neuronal Homeostasis in the Trigeminal Nucleus Caudalis. It suppresses inflammatory and oxidative stress responses, rebalances neuronal excitability and metabolism, drives microglia and astrocytes toward reparative states, and reconstructs impaired neuron–glia ...
Shiqi Sun, Shuangyuan Hu, Mingsheng Sun, Zili Tang, Yuyan Wang, Longyao Xu, Puhua Cao, Lu Liu, Rong Wang, Jing Yuan, Ying Chen, Ling Zhao   +11 more
wiley   +1 more source

Anti-AQP4-Antikörper [PDF]

, 2019
openaire   +1 more source

Glia Are Bussin’: How Single‐Cell and Spatial Transcriptomics Enlighten the Role of Neuroglia in Spinal Cord Injury and Regeneration

Glia, Volume 74, Issue 6, June 2026.
Neuroglia have been extensively profiled using single‐cell genomics, improving our understanding of their dynamics after spinal cord injury. A meta‐analysis of five single‐cell time‐course genomic studies reveals heterogeneity underscoring important challenges for interpretation.
Julio Mejia, Philip J. Horner
wiley   +1 more source

Exploring the Therapeutic Potential of Aquaporin-4 Modulation in Sepsis: Inhibitors and Facilitators. [PDF]

Int J Mol Sci
Neacșu AI, Giubelan LI, Cătălin B, Rotaru-Zăvăleanu AD, Mușat MI, Neniu EM, Irimie AI, Pirici D, Osiac E.   +8 more
europepmc   +1 more source

CXCL9 associates with experimental neuromyelitis optica spectrum disorder following adoptive transfer of Tfh and Th17 cells. [PDF]

Front Immunol
Wang L, Zhou L, Huang W, ZhangBao J, Tan H, Fan Y, Lu C, Yu J, Wang M, Lu J, Zhao C, Wang J, Quan C.   +12 more
europepmc   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source