Results 131 to 140 of about 18,365 (217)

Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange, Erica Zhao, Ellie O'Connell, Olivia Gillham, Amy McTague   +4 more
wiley   +1 more source

Multi‐Omics Integration Reveals That SN‐011 Targets JUNB to Upregulate ADGRE5 and Restore Vascular Endothelial Cell Communication in Ischemic Stroke

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Ischemic stroke (IS) remains a leading cause of disability with limited therapeutic targets. Using multi‐omics integration, we identified ADGRE5 as a protective gene significantly downregulated in venous endothelial cells (vECs) during IS. JUNB acts as a key upstream transcription factor that negatively regulates ADGRE5 expression.
XiangLing Ou, ZunKe Gong
wiley   +1 more source

A Rare Overlap of AQP4 and MOG Seropositivity in Neuromyelitis Optica Spectrum Disorder: A Case Report

Clinical and Experimental Neuroimmunology, Volume 17, Issue 3, August 2026.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is an immune‐mediated disorder of the central nervous system associated with autoantibodies against aquaporin‐4 (AQP4). This is distinct from myelin‐oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), defined by anti‐MOG antibodies.
Sarah E. Butler, Siew Kar Chen, Mastura Monif   +2 more
wiley   +1 more source

Are diurnal variations in glymphatic clearance driven by circadian regulation of Aquaporin-4 expression?

Fluids and Barriers of the CNS
Aquaporin-4 (AQP4) is a key astrocytic water channel protein predominantly localized to perivascular endfeet, where it is believed to play a crucial role in brain fluid homeostasis and glymphatic waste clearance.
Mina Martine Frey, Negar Zohoorian, Nadia Skauli, Ole Petter Ottersen, Mahmood Amiry-Moghaddam   +4 more
doaj   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Update on the Incidence of Paediatric Multiple Sclerosis, Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease, Aquaporin‐4 Antibody–Positive Neuromyelitis Optica Spectrum Disorder, and Other Acquired Demyelinating Syndromes in the Netherlands, 2017–2025, Including the COVID‐19 Pandemic

European Journal of Neurology, Volume 33, Issue 8, August 2026.
ABSTRACT Background Acquired demyelinating syndromes (ADS) in children include multiple sclerosis (MS), myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), aquaporin 4 antibody‐positive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), and other seronegative disorders.
Sandy Molenaar, Michiel S. J. Buijze, Arlette L. Bruijstens, Yu Yi M. Wong, Maud A. Quist, C. Louk de Mol, Beatrijs H. A. Wokke, Rinze F. Neuteboom, Dutch Study Group for Paediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis   +8 more
wiley   +1 more source

Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease. [PDF]

Alzheimers Dement
Palatsides EL, Yiallourou S, Himali D, Cavuoto MG, Baril AA, Yang Q, Peloso GM, Ryan J, El Fakhri G, Ghosh S, Thibault E, DeCarli CS, Johnson KA, Beiser AS, Seshadri S, Himali JJ, Pase MP.   +16 more
europepmc   +1 more source

AQP4-Autoantikörper [PDF]

, 2019
openaire   +1 more source

Unmet needs in the care of patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody associated disease: insights from Germany. [PDF]

Neurol Res Pract
Giglhuber K, Bertrand A, Zappe C, Kleiter I, Ayzenberg I, Berthele A, Neuromyelitis Optica Study Group (NEMOS).   +6 more
europepmc   +1 more source

Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets. [PDF]

Mol Biomed
Wang NN, Liu ZJ, Wang Y, Cao F, Xu D.
europepmc   +1 more source