Results 141 to 150 of about 24,501 (255)

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors

The Journal of Physiology, EarlyView.
Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck, Carlos Matellan, Cristina Bauset, Bella Raphael, Mary Nwaezeigwe, Emer Flynn, Kevin Okamoto, Desmond Winter, Colm Collins, Katie Doogan, Seán T. Martin, Glen Doherty, Seema S. Aceves, Mario C. Manresa   +13 more
wiley   +1 more source

Colocalization of MMP2 and AQP4 with GFAP and CD34 in the ischemic penumbra.

, 2014
Immunofluorescence labeling for the MMP2, AQP4, GFAP, and CD34 expression levels in the ischemic hemisphere of MCAO model group M rats. MMP2 (red, A) and GFAP (green, B) staining and the MMP2/GFAP merge (C) show MMP2 expression on astrocyte endfeet; MMP2
Hong Xu (71477), Hua Sun (406210), Yamin Zhang (563974), Fuming Wang (563976), Suhui Chen (563975)   +4 more
core   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Impact of a fluorescent AQP4 tag on NMO-IgG detection.

, 2013
Fluorescence of mCherry tagged at the AQP4 C-terminus (A) and GFP tagged at the AQP4 N-terminus (C). Immunofluorescence experiments conducted with NMO sera (collection of 20 NMO sera) on AQP4-M23mCherry (B) and GFPAQP4-M23 (D).
Angelo Sparaneo (387329), Maddalena Ruggieri (485748), Maria Grazia Mola (387330), Maria Trojano (301639), Carla Tortorella (301673), Antonio Frigeri (352675), Francesco Pisani (387328), Grazia Paola Nicchia (352672), Maria Svelto (330761)   +8 more
core   +1 more source

Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways

Scientific Reports
The aquaporin-4 (AQP4) water channel is essential in neurofluid dynamics. AQP4 loss impairs solute exchange between the cerebrospinal fluid (CSF) and interstitial fluid (ISF).
Daisuke Kato, Hiroyuki Kameda, Naoya Kinota, Takaaki Fujii, Bai Xiawei, Zhou Simi, Yoshiki Takai, Simon Chau, Yoshiki Miyasaka, Tomoji Mashimo, Yoichiro Abe, Masato Yasui, Kazuyuki Minowa, Kohsuke Kudo   +13 more
doaj   +1 more source

Single‐Cell Integration of Mouse Models of Autism Reveals Conserved Transcriptomic Signatures of Excitatory‐Inhibitory Imbalance and Glial Dysfunction

Glia, Volume 74, Issue 12, December 2026.
Integrated scRNA‐seq from 11 ASD models reveals convergent E/I imbalance and glial dysfunction. Conserved astrocyte and oligodendrocyte dysregulation transcend model‐specific variability. Validated by human datasets. ABSTRACT The etiological heterogeneity of autism spectrum disorder (ASD) complicates identifying core molecular mechanisms.
João V. Nani, Victor J. Duque, Alysson R. Muotri, André S. Mecawi   +3 more
wiley   +1 more source

Altered Water Diffusivity in Mouse AQP4-/- Brain During Development Using Diffusion Tensor Imaging [PDF]

, 2012
Aquaporin-4 (AQP4) is the glial water channel that is primarily expressed in astrocytes. Various roles of AQP4 have been previously discussed such as deletion of AQP4 induces enlarged extracellular space.
Yang, Gi Eun
core  

Molecular Control of Neural Stem Cell Quiescence in the Adult Zebrafish Telencephalon: Established Mechanisms and an Integrative Hypothesis

Glia, Volume 74, Issue 12, December 2026.
Adult zebrafish radial glia quiescence is controlled by at least four mechanisms: Notch3, BMP‐Id1, Nr2f1b and Midkine‐a. We propose these act as partially redundant inputs, biased along the antero‐posterior axis that set quiescence depth. ABSTRACT The zebrafish telencephalon is an excellent model for adult neurogenesis under physiological and ...
Mathilde Hoareau, Nicolas Diotel, Sepand Rastegar   +2 more
wiley   +1 more source

Western blot against AQP4.

, 2013
(A) C6-system: the lower band (32 kDA) represents the AQP4 isoform M23 and the upper band (34 kDA) the isoform M1. Rat control brain (lane 1), C6 cell culture (lane 2), extracranial implanted C6 cells (lane 3), intracerebral implanted C6 cells (lane 4 ...
Karen Wolburg-Buchholz (323517), Susan Noell (294230), Hartwig Wolburg (185538), Petra Fallier-Becker (323518), Rainer Ritz (294227)   +4 more
core   +1 more source