Results 161 to 170 of about 24,501 (255)

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia

MedComm, Volume 7, Issue 11, November 2026.
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song, Li‐Rong Zhang, Yun‐Mei Wang, Yan Hu, Qing Li, Ren‐Rong Tian, Liu‐Meng Yang, Si‐Dong Xiong, Dong‐Dong Wu, Yong‐Tang Zheng   +9 more
wiley   +1 more source

Spp1 Appears to Be a Key Gene for Sporadic Obstructive Hydrocephalus in the Absence of AQP4

Aquaporin-4 (AQP4) is expressed in ependymal cells bordering the ventricles, the glia limitans, and pericapillary astrocyte endfeet forming the blood–brain barrier.
Trillo-Contreras, Jos\ue9 Luis, Carmen Ortiz-Salguero, Hiraldo-Gonz\ue1lez, Laura, Reposo Ramírez-Lorca, Francisco D. Rodríguez-Gómez, Rodr\uedguez-G\uf3mez, Francisco D., Villadiego, Javier, Francisco Mayo, Miriam Echevarría, Echevarr\ueda, Miriam, Mayo, Francisco, Ortiz-Salguero, Carmen, Ram\uedrez-Lorca, Reposo, José Luis Trillo-Contreras, Javier Villadiego, Sobh-Doush, Elaheh, Rodríguez-Gómez, Francisco D., Ortiz Salguero, Carmen, Hiraldo-González, Laura, Ramírez-Lorca, Reposo, Elaheh Sobh-Doush, Trillo-Contreras, José Luis, Laura Hiraldo-González, Echevarría, Miriam   +23 more
core   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

AQP4-Autoantikörper [PDF]

, 2019
openaire   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2309-2320, November 2026.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, Volume 36, Issue 6, November 2026.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, Volume 36, Issue 6, November 2026.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Absolute Counts of Circulating T Follicular Helper Cell Subsets in Acute‐Phase AQP4‐IgG–Positive Neuromyelitis Optica Spectrum Disorder

Clinical and Experimental Neuroimmunology, Volume 17, Issue 4, November 2026.
ABSTRACT Objectives Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease characterized by pathogenic anti‐aquaporin‐4 (AQP4) antibodies. Previous studies have shown increased circulating T follicular helper (cTfh) cells and altered Tfh subset frequencies in NMOSD, but the absolute counts of Tfh subsets remain unclear. We
Takafumi Hosokawa, Hideto Nakajima, Manami Matsushita, Takahiro Akamatsu, Shoji Ogawa, Shin Ota, Hiroko Tanada, Shigeki Arawaka   +7 more
wiley   +1 more source

Spatial organization of AQP4 water channel expression in the human brain. [PDF]

Sci Adv
Taheri T, Farahani A, Liu ZQ, Ceballos EG, Harroud A, Dagher A, Misic B.   +6 more
europepmc   +1 more source

Paraneoplastic and Autoimmune Retinopathy Presenting as Isolated Neuro‐Ophthalmic Dysfunction: Two Cases

Clinical and Experimental Neuroimmunology, Volume 17, Issue 4, November 2026.
ABSTRACT Background Paraneoplastic and autoimmune retinopathies can cause progressive visual loss before structural ophthalmic or neurologic findings are diagnostic. Case Presentation A 66‐year‐old woman developed bilateral visual decline and was diagnosed with small‐cell lung cancer‐associated paraneoplastic neuroretinal dysfunction, with persistent ...
Alan B. Dogan, Dean Neutel, Anthony L. Loschner   +2 more
wiley   +1 more source