Results 11 to 20 of about 24,909,638 (279)

New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases

Neurobiology of Disease
Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of ...
Yan-rui Sun, Qian-Kun Lv, Jun-Yi Liu, Fen Wang, Chun-Feng Liu   +4 more
doaj   +6 more sources

Glymphatic system: a self-purification circulation in brain

Frontiers in Cellular Neuroscience
The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage ...
Siying Chen, Siying Chen, Huijing Wang, Lini Zhang, Yingying Xi, Yiying Lu, Kailin Yu, Yujie Zhu, Izmailova Regina, Yong Bi, Fang Tong, Fang Tong   +11 more
doaj   +4 more sources

The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle

Neurobiology of Disease
The term “glymphatic” emerged roughly a decade ago, marking a pivotal point in neuroscience research. The glymphatic system, a glial-dependent perivascular network distributed throughout the brain, has since become a focal point of investigation.
Yu Cai, Yangqiqi Zhang, Shuo Leng, Yuanyuan Ma, Quan Jiang, Qiuting Wen, Shenghong Ju, Jiani Hu   +7 more
doaj   +4 more sources

PDGF-B Is Required for Development of the Glymphatic System [PDF]

Cell Reports, 2019
Summary: The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways.
Anne Sofie Munk, Wei Wang, Nicholas Burdon Bèchet, Ahmed M. Eltanahy, Anne Xiaoan Cheng, Björn Sigurdsson, Abdellatif Benraiss, Maarja A. Mäe, Benjamin Travis Kress, Douglas H. Kelley, Christer Betsholtz, Kjeld Møllgård, Anja Meissner, Maiken Nedergaard, Iben Lundgaard   +14 more
doaj   +9 more sources

Glymphatic system and psychiatric disorders: need for a new paradigm? [PDF]

Front Psychiatry
Psychiatric disorders like depression, bipolar disorder, schizophrenia, and post-traumatic stress Disorder have conventionally theorized on alterations in neurotransmitters, receptor pharmacodynamics, and neural connectivity.
Barlattani T, Cavatassi A, Bologna A, Socci V, Trebbi E, Malavolta M, Rossi A, Martiadis V, Tomasetti C, De Berardis D, Di Lorenzo G, Pacitti F.   +11 more
europepmc   +2 more sources

Glymphatic System Dysfunction in Central Nervous System Diseases and Mood Disorders

Frontiers in Aging Neuroscience, 2022
The glymphatic system, a recently discovered macroscopic waste removal system in the brain, has many unknown aspects, especially its driving forces and relationship with sleep, and thus further explorations of the relationship between the glymphatic ...
Dianjun Zhang, Dianjun Zhang, Dianjun Zhang, Xinyu Li, Xinyu Li, Xinyu Li, Baoman Li, Baoman Li, Baoman Li   +8 more
doaj   +3 more sources

The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices

Brain Sciences, 2020
The glymphatic system is a “pseudo-lymphatic” perivascular network distributed throughout the brain, responsible for replenishing as well as cleansing the brain.
Oliver Cameron Reddy, Ysbrand D. van der Werf   +1 more
doaj   +3 more sources

Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease

Neural Regeneration Research
The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson’s disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of ...
Xiaoyue Lian, Zhenghao Liu, Zuobin Gan, Qingshan Yan, Luyao Tong, Linan Qiu, Yuntao Liu, Jiang-fan Chen, Zhihui Li   +8 more
doaj   +2 more sources

Glymphatic system: a gateway for neuroinflammation

Neural Regeneration Research, 2023
The glymphatic system is a relatively recently identified fluid exchange and transport system in the brain. Accumulating evidence indicates that glymphatic function is impaired not only in central nervous system disorders but also in systemic diseases ...
Kailu Zou, Qingwei Deng, Hong Zhang, Changsheng Huang   +3 more
doaj   +3 more sources

Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review [PDF]

Frontiers in Neuroscience
IntroductionPrevious studies have shown that the proper functioning of both mitochondria and the glymphatic system transporting metabolites are essential for brain health.
Tilda Pihala, Vesa Kiviniemi, Vesa Kiviniemi, Vesa Kiviniemi, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen   +7 more
doaj   +2 more sources