Results 51 to 60 of about 24,909,638 (279)

Association of glymphatic system function with peripheral inflammation and motor symptoms in Parkinson’s disease

npj Parkinson's Disease
Growing evidence highlights the roles of glymphatic system and peripheral inflammation in Parkinson’s disease (PD). We evaluated their interrelationship and potential mechanisms contributing to motor symptoms using DTI-ALPS and inflammatory markers ...
Ruo-Lan Lin, Guoen Cai, Ying Chen, Jinmei Zheng, Shu Wang, Huinan Xiao, Qinyong Ye, Yunjing Xue, Rifeng Jiang   +8 more
semanticscholar   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Convective infux/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways [PDF]

Tracers injected into CSF pass into the brain alongside arteries and out again. This has been recently termed the "glymphatic system" that proposes tracers enter the brain along periarterial "spaces" and leave the brain along the walls of veins.
Albargothy, Nazira J., Carare, Roxana O., Hawkes, Cheryl A., Johnston, David A., MacGregor-Sharp, Matthew, Verma, Ajay, Weller, Roy O.   +6 more
core   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Perivascular Spaces, Glymphatic System and MR

Frontiers in Neurology, 2022
The importance of the perivascular space (PVS) as one of the imaging markers of cerebral small vessel disease (CSVD) has been widely appreciated by the neuroradiologists. The PVS surrounds the small blood vessels in the brain and has a signal consistent with the cerebrospinal fluid (CSF) on MR.
Linya Yu, Xiaofei Hu, Haitao Li, Yilei Zhao   +3 more
openaire   +3 more sources

Magnetic Resonance Imaging and Modeling of the Glymphatic System

Diagnostics, 2020
The glymphatic system is a newly discovered waste drainage pathway in the brain; it plays an important role in many neurological diseases. Ongoing research utilizing various cerebrospinal fluid tracer infusions, either directly or indirectly into the ...
Jasleen Kaur, Esmaeil Davoodi-Bojd, Lara M Fahmy, Li Zhang, Guangliang Ding, Jiani Hu, Zhenggang Zhang, Michael Chopp, Quan Jiang   +8 more
doaj   +1 more source

Glymphatic system: an emerging therapeutic approach for neurological disorders

Frontiers in Molecular Neuroscience, 2023
The functions of the glymphatic system include clearance of the metabolic waste and modulation of the water transport in the brain, and it forms a brain-wide fluid network along with cerebrospinal fluid (CSF) and interstitial fluid (ISF).
Ying Gao, Kangding Liu, Jie Zhu, Jie Zhu
doaj   +1 more source

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation [PDF]

Sleep deprivation reduces the dextran radial distribution and 125I-apoE inflow from CSF into brain. A-B) Representative images of cascade blue dextran (CB) in mice on normal sleep cycle (A) and in mice during sleep deprivation (SD) (B).
Achariyar, Thiyagaragan M, Benraiss, Abdellatif, Deane, Rashid, Holtzman, David, Kasper, Tristan, Li, Baoman, McConnell, Evan, Nedergaard, Maiken, Peng, Weiguo, Shi, Yang, Song, Wei, Takana, Takahiro, Verghese, Philip B   +12 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Aquaporin‐4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Narcolepsy type 1 (NT1) is caused by the loss of hypocretin‐1 leading to excessive daytime sleepiness and cataplexy. Additionally, disrupted nighttime sleep has become an increasingly recognized feature of NT1. As the glymphatic fluid movement has been linked to sleep architecture, we investigated cerebrospinal fluid (CSF) Aquaporin‐4 (AQP4 ...
Jonas Ranke, Petra Steinacker, Steffen Halbgebauer, Patrick Oeckl, Geert Mayer, Markus Otto   +5 more
wiley   +1 more source