Results 71 to 80 of about 24,909,638 (279)

Idiopathic Intracranial Hypertension Is Characterized by a Distinct Proteomic Profile

Annals of Neurology, EarlyView.
Objectives The pathophysiology of idiopathic intracranial hypertension (IIH) is poorly understood and disease‐specific biomarkers are lacking. We aimed to shed light on IIH pathophysiology and identify disease‐specific biomarkers. Methods This prospective cross‐sectional cohort study included patients with new‐onset IIH and age‐, body mass index‐, and ...
Santosh D. Bhosale, Arkadiusz Nawrocki, Johanne J. Korsbæk, Nadja S. Hansen, Fabian Foettinger, Nik Krajnc, Mathias J. Norvig, Niclas L. Eriksen, Stefan Macher, Berthold Pemp, Connar S.J. Westgate, Christian B. Pedersen, Frantz R. Poulsen, Sune Munthe, Gabriel Bsteh, Martin R. Larsen, Rigmor H. Jensen, Dagmar Beier   +17 more
wiley   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Astrocytes and neurons communicate via a monocarboxylic acid shuttle [PDF]

Since formulation of the Astrocyte-Neuron Lactate Shuttle (ANLS) hypothesis in 1994, the hypothesis has provoked criticism and debate. Our review does not criticise, but rather integrates experimental data characterizing proton-linked monocarboxylate ...
Cottrell, Graeme S., Roosterman, Dirk
core   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system

Frontiers in Psychiatry
The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and ...
Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jiadi Xu, Jiadi Xu, Jun Hua, Jun Hua, Peter van Zijl, Peter van Zijl, Linda Knutsson, Linda Knutsson, Linda Knutsson   +13 more
doaj   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Glymphatic dysfunction couples with cortical excitation–inhibition imbalance in epilepsy: Evidence from Rasmussen encephalitis

Epilepsia, EarlyView.
Cong Fu et al. demonstrate that glymphatic system dysfunction is linked to enhanced inhibitory cortical activity using diffusion MRI and EEG. These findings highlight a mechanistic link between perivascular fluid dynamics and neuronal activity, suggesting a role for glymphatic function in maintaining cortical stability in epilepsy.
Cong Fu, Yujiao Yang, Pan Gong, Kun Lv, Yilin Liu, Chongyang Tang, Xiongfei Wang, Lixin Cai, Qingzhu Liu, Yuwu Jiang, Taoyun Ji, Guoming Luan   +11 more
wiley   +1 more source

Investigating cerebral oedema using poroelasticity [PDF]

Cerebral oedema can be classified as the tangible swelling produced by expansion of the interstitial fluid volume. Hydrocephalus can be succinctly described as the abnormal accumulation of cerebrospinal fluid (CSF) within the brain which ultimately leads
Chou, D, Hung, CC, Lee, TH, Tsui, PH, Tully, BJ, Vardakis, IC, Ventikos, Y   +6 more
core   +1 more source

Evaluation of Soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) in Cerebrospinal Fluid, Serum, and Plasma Using the Fully Automated Lumipulse Platform

Journal of Clinical Laboratory Analysis, EarlyView.
Relationship between serum and CSF sTREM2 concentration. ABSTRACT Background In this study, we first evaluated the relationship between sTREM2 concentrations in CSF, serum, and plasma of Alzheimer's disease (AD) patients using the newly developed Lumipulse G sTREM2 assay.
Luisa Agnello, Anna Maria Ciaccio, Fabio Del Ben, Caterina Maria Gambino, Tommaso Piccoli, Mauro Midiri, Concetta Scazzone, Anna Masucci, Martina Tamburello, Marcello Ciaccio   +9 more
wiley   +1 more source

The role and mechanism of Aβ clearance dysfunction in the glymphatic system in Alzheimer’s disease comorbidity

Frontiers in Neurology
Alzheimer’s disease (AD) is the leading type of dementia globally, characterized by a complex pathogenesis that involves various comorbidities. An imbalance in the production and clearance of amyloid β-protein (Aβ) peptides in the brain is a key ...
Hailang Li, Qianqian Yao, Xueyan Huang, Xiaoyan Yang, Changyin Yu   +4 more
doaj   +1 more source