Results 61 to 70 of about 18,116,541 (240)

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

The glymphatic system and cerebral small vessel disease [PDF]

Objectives: Cerebral small vessel disease is a group of pathologies in which alterations of the brain's blood vessels contribute to stroke and neurocognitive changes.
Zhang, Douglas M., Azizi, Saara-Anne, Brorson, James R., Norton de Matos, Salvador A., Ang, Phillip S.   +4 more
core   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system

Frontiers in Psychiatry
The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and ...
Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jiadi Xu, Jiadi Xu, Jun Hua, Jun Hua, Peter van Zijl, Peter van Zijl, Linda Knutsson, Linda Knutsson, Linda Knutsson   +13 more
doaj   +1 more source

Stress and the glymphatic system

, 2020
Psychoneuroendocrinoimmunology (PNEI) is an integrative discipline studying the processes by which mental events modulate immune functions and how the immune system in turn can alter brain function. The central nervous system (CNS) is the only system in the body lacking its own anatomically defined lymphatic vessels.
Mariya Ivanovska, Meral Naimova, Marianna Murdjeva   +2 more
openaire   +1 more source

Striatal Dopaminergic Reserve Shapes the Longitudinal Impact of Peripheral Immune Activation on Motor Progression in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Peripheral immune dysregulation has been implicated in Parkinson's disease (PD) progression, but whether motor deterioration reflects accelerated nigrostriatal degeneration or residual dopaminergic reserve remains unclear. Objectives To examine whether baseline and time‐varying neutrophil‐to‐lymphocyte ratio (NLR) relate to motor ...
Osman Kahveci, Ulaş Ay, Tamer Demiralp
wiley   +1 more source

Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review

Frontiers in Neuroscience
IntroductionPrevious studies have shown that the proper functioning of both mitochondria and the glymphatic system transporting metabolites are essential for brain health.
Tilda Pihala, Vesa Kiviniemi, Vesa Kiviniemi, Vesa Kiviniemi, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen   +7 more
doaj   +1 more source

Whole‐Brain Cerebral Microvascular Pulsatility Imaging Using Dynamic pCASL MRI With Segmented Stack‐of‐Stars Golden‐Angle Radial Acquisition

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To develop an efficient dynamic pseudo‐continuous arterial spin labeling (pCASL) MRI technique for whole‐brain microvascular flow pulsatility imaging. Methods The proposed technique combines pCASL with a segmented stack‐of‐stars golden‐angle radial acquisition.
Tianrui Zhao, Jianing Tang, Yining He, Dilip K. Pandey, Philip B. Gorelick, Lirong Yan   +5 more
wiley   +1 more source

In Vivo Dynamic D2O‐MRI for Quantifying Apparent CSF Water Renewal Across Ventricular and Extraventricular Compartments

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose The choroid plexus has long been regarded as the principal source of cerebrospinal fluid (CSF), yet this view remains unresolved. We developed a dynamic indirect D2O MRI approach to quantify regional apparent CSF water renewal in vivo in rats at 9.4 T.
Zhao Zhang, Yun Wu, Yanmin Zheng, Zhuoyang Lin, Ye Li, Qiong Ye   +5 more
wiley   +1 more source

Interplay between the glymphatic system and neurotoxic proteins in Parkinson's disease and related disorders: current knowledge and future directions

Neural Regeneration Research
Parkinson's disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins, including α-synuclein, amyloid-β, and tau, in addition to the impaired elimination of these neurotoxic ...
Yumei Yue, Xiaodan Zhang, Wen Lv, Hsin-Yi Lai, Ting Shen   +4 more
doaj   +1 more source