Results 61 to 70 of about 9,639 (217)

Impaired glymphatic transport in hypoxic-ischemic encephalopathy

NeuroImage
Hypoxic-ischemic encephalopathy (HIE) is a major cause of neonatal brain injury. The glymphatic system aids in waste clearance via perivascular pathways and is crucial in maintaining brain functions.
Jieyi Shen, Ying Yang, Fangfang Chen, Yang Zuo, Yidong Yang, Wei Wei, Ying Liu, Jie Wen   +7 more
doaj   +1 more source

Attenuation of cerebral edema facilitates recovery of glymphatic system function after status epilepticus

JCI Insight, 2021
Status epilepticus (SE) is a neurological emergency usually accompanied by acute cerebral edema and long-term cognitive impairment, and is characterized by neurodegeneration and aberrant hyperphosphorylated tau protein (p-tau) aggregation.
Kewei Liu, Juan Zhu, Yuan Chang, Zhenzhou Lin, Zhu Shi, Xing Li, Xing Chen, Chuman Lin, Suyue Pan, Kaibin Huang   +9 more
doaj   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

NIR-II nanoprobes for investigating the glymphatic system function under anesthesia and stroke injury

Journal of Nanobiotechnology
The glymphatic system plays an important role in the transportation of cerebrospinal fluid (CSF) and the clearance of metabolite waste in brain. However, current imaging modalities for studying the glymphatic system are limited.
Bin Sun, Danlan Fang, Wenzhong Li, Mengfei Li, Shoujun Zhu   +4 more
doaj   +1 more source

Targeting the glymphatic system to promote α-synuclein clearance: a novel therapeutic strategy for Parkinson’s disease

Neural Regeneration Research
The excessive buildup of neurotoxic α-synuclein plays a pivotal role in the pathogenesis of Parkinson’s disease, highlighting the urgent need for innovative therapeutic strategies to promote α-synuclein clearance, particularly given the current lack of ...
Xiaoyue Lian, Zhenghao Liu, Zuobin Gan, Qingshan Yan, Luyao Tong, Linan Qiu, Yuntao Liu, Jiang-fan Chen, Zhihui Li   +8 more
doaj   +1 more source

WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse

Epilepsia, EarlyView.
Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper, Zining Liu, Aristea S. Galanopoulou, Gernot Hlauschek, Benjamin Sinclair, Wai Lam Leung, Stefanie Dedeurwaerdere, Elisabeth Doran, Solomon L. Moshé, David C. Henshall, Ozlem Akman, Pablo M. Casillas‐Espinosa   +11 more
wiley   +1 more source

Arterial Perivascular Space‐Mediated Solute Transport in the Mouse Brain

Exploration, EarlyView.
The mechanisms underlying solute clearance from the brain parenchyma remain debated, with competing hypotheses involving bulk cerebrospinal fluid flow versus perivascular transport. Using multimodal in vivo imaging and computational modeling in mice, this study demonstrates that arterial pulsation drives bidirectional solute movement within the ...
Shiyong Li, Ye Wang, Guangyu Jia, Yamei Yu, Zhe Zhang, Qi Wang, Kaelyn V. Becker, Jonathan W. Engle, Dawei Jiang, Weibo Cai   +9 more
wiley   +1 more source

Emerging Issues for Counselors Applying Neuroscience With Black Clients: Avoiding Scientific Racism

Journal of Multicultural Counseling and Development, EarlyView.
ABSTRACT Neuroscience‐infused methods are heavily impacting the manner in which counselors, educators, and researchers approach working with clients and conducting research. While some scholars perceive neuroscience as scientifically objective and culturally neutral, that is not entirely true.
Isaac Burt
wiley   +1 more source

Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system

Frontiers in Psychiatry
The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and ...
Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jiadi Xu, Jiadi Xu, Jun Hua, Jun Hua, Peter van Zijl, Peter van Zijl, Linda Knutsson, Linda Knutsson, Linda Knutsson   +13 more
doaj   +1 more source

MRI Diffusion Tensor Image Analysis Along the Perivascular Space: Effects of Mean Tract Orientation Divergence

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background The diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index is an established term, and ongoing research aims to explore underlying mechanisms. Hypothesis DTI‐ALPS measures are influenced by subject‐specific orientational differences of the projection and association fibers. Study Type Prospective.
Dávid Bognár, Gergely Orsi, Csirmaz Benedek, Szilvia A. Nagy, Gergely Darnai, Barnabás Dudás, Ákos Arató, Norbert Kovács, József Janszky, Gábor Perlaki   +9 more
wiley   +1 more source