Results 61 to 70 of about 12,211 (230)

Glymphatic system: a self-purification circulation in brain

Frontiers in Cellular Neuroscience
The glymphatic system theory introduces a new perspective on fluid flow and homeostasis in the brain. Here, cerebrospinal fluid and interstitial fluid (CSF-ISF) moves from the perivascular spaces (PVS) of arteries to those of veins for drainage ...
Siying Chen, Siying Chen, Huijing Wang, Lini Zhang, Yingying Xi, Yiying Lu, Kailin Yu, Yujie Zhu, Izmailova Regina, Yong Bi, Fang Tong, Fang Tong   +11 more
doaj   +1 more source

Spatial model of convective solute transport in brain extracellular space does not support a "glymphatic" mechanism. [PDF]

, 2016
A "glymphatic system," which involves convective fluid transport from para-arterial to paravenous cerebrospinal fluid through brain extracellular space (ECS), has been proposed to account for solute clearance in brain, and aquaporin-4 water channels in ...
Jin, Byung-Ju, Smith, Alex J, Verkman, Alan S   +2 more
core  

A mixed finite element method for nearly incompressible multiple-network poroelasticity

, 2018
In this paper, we present and analyze a new mixed finite element formulation of a general family of quasi-static multiple-network poroelasticity (MPET) equations.
Lee, Jeonghun J., Mardal, Kent-Andre, Piersanti, Eleonora, Rognes, Marie E.   +3 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Combining H-FABP and GFAP increases the capacity to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury [PDF]

, 2018
Mild traumatic brain injury (mTBI) patients may have trauma-induced brain lesions detectable using CT scans. However, most patients will be CT-negative. There is thus a need for an additional tool to detect patients at risk. Single blood biomarkers, such
Bustamante, Alejandro, Egea Guerrero, Juan José, El Rahal, Amir, García-Armengol, Roser, Lagerstedt, Linnéa, Melinda Prica, Carmen, Montaner, Joan, Quintana-Díaz, Manuel, Rodríguez Rodríguez, Ana   +8 more
core   +1 more source

Impairment of the glymphatic system after diabetes [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2016
The glymphatic system has recently been shown to clear brain extracellular solutes and abnormalities in glymphatic clearance system may contribute to both initiation and progression of neurological diseases. Despite that diabetes is known as a risk factor for vascular diseases, little is known how diabetes affects the glymphatic system.
Jiang, Quan, Zhang, Li, Ding, Guangliang, Davoodi-Bojd, Esmaeil, Li, Qingjiang, Li, Lian, Sadry, Neema, Nedergaard, Maiken, Chopp, Michael, Zhang, Zhenggang   +9 more
openaire   +3 more sources

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Magnetic Resonance Imaging and Modeling of the Glymphatic System

Diagnostics, 2020
The glymphatic system is a newly discovered waste drainage pathway in the brain; it plays an important role in many neurological diseases. Ongoing research utilizing various cerebrospinal fluid tracer infusions, either directly or indirectly into the ...
Jasleen Kaur, Esmaeil Davoodi-Bojd, Lara M Fahmy, Li Zhang, Guangliang Ding, Jiani Hu, Zhenggang Zhang, Michael Chopp, Quan Jiang   +8 more
doaj   +1 more source

Amyloid mis-metabolism in idiopathic normal pressure hydrocephalus [PDF]

, 2016
BACKGROUND: Patients with idiopathic normal pressure hydrocephalus (iNPH) have reduced cerebrospinal fluid (CSF) concentrations of amyloid-β (Aβ) and α- and β-cleaved soluble forms of amyloid precursor protein (sAPPα and sAPPβ).
Blennow, K, Höltta, M, Jeppsson, A, Tullberg, M, Wikkelsø, C, Zetterberg, H   +5 more
core   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source