Results 61 to 70 of about 17,183,881 (176)

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, EarlyView.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

The glymphatic system in Huntington's disease

Journal of Huntington's Disease
The glymphatic system, a macroscopic waste clearance network in the brain, plays a vital role in maintaining neuronal health and brain homeostasis. Functionally analogous to the lymphatic system in other organs, the term “glymphatic” combines “glial” and “lymphatic.” This system facilitates the exchange of cerebrospinal fluid (CSF) and interstitial ...
Wenzhen Duan, Yuan Zhou, Hongshuai Liu
openaire   +3 more sources

Exploring neurodegenerative disorders using advanced magnetic resonance imaging of the glymphatic system

Frontiers in Psychiatry
The glymphatic system, a macroscopic waste clearance system in the brain, is crucial for maintaining neural health. It facilitates the exchange of cerebrospinal and interstitial fluid, aiding the clearance of soluble proteins and metabolites and ...
Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jannik Prasuhn, Jiadi Xu, Jiadi Xu, Jun Hua, Jun Hua, Peter van Zijl, Peter van Zijl, Linda Knutsson, Linda Knutsson, Linda Knutsson   +13 more
doaj   +1 more source

Stress and the glymphatic system

, 2020
Psychoneuroendocrinoimmunology (PNEI) is an integrative discipline studying the processes by which mental events modulate immune functions and how the immune system in turn can alter brain function. The central nervous system (CNS) is the only system in the body lacking its own anatomically defined lymphatic vessels.
Mariya Ivanovska, Meral Naimova, Marianna Murdjeva   +2 more
openaire   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Associations between the brain glymphatic system and mitochondrial (dys)function: a systematic review

Frontiers in Neuroscience
IntroductionPrevious studies have shown that the proper functioning of both mitochondria and the glymphatic system transporting metabolites are essential for brain health.
Tilda Pihala, Vesa Kiviniemi, Vesa Kiviniemi, Vesa Kiviniemi, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen, Mika H. Martikainen   +7 more
doaj   +1 more source

WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse

Epilepsia, EarlyView.
Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper, Zining Liu, Aristea S. Galanopoulou, Gernot Hlauschek, Benjamin Sinclair, Wai Lam Leung, Stefanie Dedeurwaerdere, Elisabeth Doran, Solomon L. Moshé, David C. Henshall, Ozlem Akman, Pablo M. Casillas‐Espinosa   +11 more
wiley   +1 more source

The role and mechanism of Aβ clearance dysfunction in the glymphatic system in Alzheimer’s disease comorbidity

Frontiers in Neurology
Alzheimer’s disease (AD) is the leading type of dementia globally, characterized by a complex pathogenesis that involves various comorbidities. An imbalance in the production and clearance of amyloid β-protein (Aβ) peptides in the brain is a key ...
Hailang Li, Qianqian Yao, Xueyan Huang, Xiaoyan Yang, Changyin Yu   +4 more
doaj   +1 more source

A SPECT-based method for dynamic imaging of the glymphatic system in rats

, 2023
The glymphatic system is a brain-wide waste drainage system that promotes cerebrospinal fluid circulation through the brain to remove waste metabolites.
Laura Klinger, Rosenholm, Marko P., Mogensen, Frida L.H., Tuomas O Lilius, Hauglund, Natalie L., Matthias Herth, Beschorner, Natalie, Natalie Beschorner, Sigurdsson, Björn, Simone L Bærentzen, Lilius, Tuomas O., Maiken Nedergaard, Marko P Rosenholm, Mortensen, Kristian N., Frida L-H Mogensen, Nedergaard, Maiken, Herth, Matthias, Björn Sigurdsson, Bærentzen, Simone L., Natalie L Hauglund, Kristian N Mortensen, Klinger, Laura, Vladimir Shalgunov, Shalgunov, Vladimir, Yuki Mori, Mori, Yuki   +25 more
core   +1 more source

Emerging Issues for Counselors Applying Neuroscience With Black Clients: Avoiding Scientific Racism

Journal of Multicultural Counseling and Development, EarlyView.
ABSTRACT Neuroscience‐infused methods are heavily impacting the manner in which counselors, educators, and researchers approach working with clients and conducting research. While some scholars perceive neuroscience as scientifically objective and culturally neutral, that is not entirely true.
Isaac Burt
wiley   +1 more source