Results 81 to 90 of about 18,116,541 (240)

Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus

, 2020
Approximately 10% of dementia patients have idiopathic normal pressure hydrocephalus (iNPH), an expansion of the cerebrospinal fluid (CSF)-filled brain ventricles.
Alper, Seth L., Cerci, H. Mert, Kundishora, Adam J., Lundgaard, Iben, Reeves, Benjamin C., Karimy, Jason K., Nedergaard, Maiken, Kahle, Kristopher T., Mestre, Humberto, Matouk, Charles, Reeves, Benjamin C.,, Kahle, Kristopher T.,, Lundgaard, Iben,, Kundishora, Adam J.,, Cerci, H. Mert,, Nedergaard, Maiken,, Alper, Seth L.,, Mestre, Humberto,, Karimy, Jason K.,, ÇERÇİ, HÜSEYİN MERT, Lund University., Matouk, Charles,   +21 more
core   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source

Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function

IUBMB Life
AbstractMicroglia, as immune cells in the central nervous system, possess the ability to adapt morphologically and functionally to their environment. Glymphatic system, the principal waste clearance system in the brain, exhibits circadian rhythms. However, the impact of microglia on the glymphatic system function remains unknown.
Ting Yang, Yan Tang, Xinghua Liu, Song Gong, Ensheng Yao   +4 more
openaire   +2 more sources

A SPECT-based method for dynamic imaging of the glymphatic system in rats

, 2023
The glymphatic system is a brain-wide waste drainage system that promotes cerebrospinal fluid circulation through the brain to remove waste metabolites.
Laura Klinger, Rosenholm, Marko P., Mogensen, Frida L.H., Tuomas O Lilius, Hauglund, Natalie L., Matthias Herth, Beschorner, Natalie, Natalie Beschorner, Sigurdsson, Björn, Simone L Bærentzen, Lilius, Tuomas O., Maiken Nedergaard, Marko P Rosenholm, Mortensen, Kristian N., Frida L-H Mogensen, Nedergaard, Maiken, Herth, Matthias, Björn Sigurdsson, Bærentzen, Simone L., Natalie L Hauglund, Kristian N Mortensen, Klinger, Laura, Vladimir Shalgunov, Shalgunov, Vladimir, Yuki Mori, Mori, Yuki   +25 more
core   +1 more source

The characteristics of perivascular proinflammation in 4‐repeat tauopathies

Brain Pathology, EarlyView.
The spatial distribution of perivascular proinflammation differs between PSP and CBD: PSP shows a predominance in basal ganglia (BG), whereas CBD demonstrates more widespread involvement of both BG and superior/middle frontal gyrus (S/M‐FG). PSP exhibits profound proinflammatory activation around venules while CBD affects a comparable magnitude around ...
Mu‐Hui Fu, Gokhan Uruk, Rodolfo G. Gatto, R. Ross Reichard, Jennifer L. Whitwell, Keith A. Josephs   +5 more
wiley   +1 more source

Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration

Cells
The key to the effective treatment of neurodegenerative disorders is a thorough understanding of their pathomechanism. Neurodegeneration and neuroinflammation are mutually propelling brain processes.
Stanisław Szlufik, Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski   +3 more
doaj   +1 more source

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Glymphatic System in Adolescents with Major Depressive Disorder: No Dysfunction and No Association with Poor Sleep Quality [PDF]

Jie Zhang,1 Xingxiong Zou,1 Xianjie Cai,2 Menghong Zou,1 Hongwei Li,1 Ruohan Feng1 1Department of Radiology, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang Sichuan, 621000, People’s Republic of China; 2Department of Radiology, MOE
Zou X, Li H, Zhang J, Zou M, Feng R, Cai X   +5 more
core  

The structure, functions and clinical significance of the glymphatic system [PDF]

, 2021
The glymphatic system is a newly discovered waste cleaning system. It provides active removal of metabolites and soluble proteins from the central nervous system (CNS).
Tansu Kuşat, Emrah Sur
core  

Shared dysregulation of complement and phosphorylation pathways in the cerebrospinal fluid of encephalitis, Aicardi–Goutières syndrome, and autism

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To identify shared and disorder‐specific molecular alterations across encephalitis, Aicardi–Goutières syndrome (AGS), and autism spectrum disorder (ASD) using cerebrospinal fluid (CSF) proteomics. Method In this cross‐sectional case–control study, mass‐spectrometry‐based proteomics was performed on archived CSF samples collected between ...
Omar H. Shadid, Peter G. Hains, Velda X. Han, Jingya Yan, Michael Griffiths, Ignatius Pang, Sushil Bandodkar, Phillip J. Robinson, Russell C. Dale   +8 more
wiley   +1 more source