Results 81 to 90 of about 9,639 (217)

The structure, functions and clinical significance of the glymphatic system [PDF]

, 2021
The glymphatic system is a newly discovered waste cleaning system. It provides active removal of metabolites and soluble proteins from the central nervous system (CNS).
Tansu Kuşat, Emrah Sur
core  

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

Brain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich, David S. Priemer, Charles Harker Rhodes, Daniel P. Perl, Kurenai Tanji, James E. Goldman   +5 more
wiley   +1 more source

Brain Glymphatic System [PDF]

, 2018
Táto práca je venovaná problematike glymfatického systému, ako potenciálneho mechanizmu pre odstránenie metabolického odpadu z mozgu. Jedná sa o kapitoly, ktoré zahŕňajú základné poznatky o anatómii a funkcii centrálneho nervového systému a mozgu, objav ...
Záhorská, Alexandra
core  

A new glaucoma hypothesis: a role of glymphatic system dysfunction [PDF]

, 2015
: In a recent review article titled A new look at cerebrospinal fluid circulation, Brinker et al. comprehensively described novel insights from molecular and cellular biology as well as neuroimaging research, which indicate that cerebrospinal fluid (CSF)
Hanspeter Esriel Killer, Veva De Groot, Wostyn, Peter, Killer, Hanspeter Esriel, Peter Wostyn, De Deyn, Peter Paul, Audenaert, Kurt, De Groot, Veva, Debby Van Dam, Van Dam, Debby, Kurt Audenaert, Peter Paul De Deyn   +11 more
core   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, EarlyView.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Neurosurgery and the glymphatic system

Acta Neurochirurgica
Abstract The discovery of the glymphatic system has fundamentally altered our comprehension of cerebrospinal fluid transport and the removal of waste from brain metabolism. In the past decade, since its initial characterization, research on the glymphatic system has surged exponentially.
openaire   +2 more sources

Alteration of the glymphatic system in Alzheimer disease compared to non-Alzheimer dementia: a single center PET/MRI study [PDF]

openBackground: The glymphatic system clears brain waste via cerebrospinal fluid (CSF) perivascular routes, maintaining homeostasis, but its function is disrupted in neurological disorders such as Alzheimer disease (AD).
DAL SANTO, ARIANNA
core  

Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration

Cells
The key to the effective treatment of neurodegenerative disorders is a thorough understanding of their pathomechanism. Neurodegeneration and neuroinflammation are mutually propelling brain processes.
Stanisław Szlufik, Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski   +3 more
doaj   +1 more source

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source