Results 101 to 110 of about 9,639 (217)

The Ocular Glymphatic Clearance System [PDF]

, 2019
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified a novel ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve.
L R Xavier, Anna, Lu, Chen, Jørgensen, Peter Kusk, Ertürk, Ali, Wang, Xiaowei, Eberhardt, Allison, Shi, Meng, Libby, Richard T., Yang, Yujia, Xu, Qiwu, Thrane, Alexander, Peng, Sisi, Nedergaard, Maiken, Lou, Nanhong, Foerstera, Benjamin   +14 more
core   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

Glucocorticoid signalling coordinating circadian rhythms between the glymphatic system and sleep contributes to brain health [PDF]

Exploration of Endocrine and Metabolic Diseases
Circadian rhythms are present in almost every cell of the body and play important roles in various physiological processes. The central circadian clock in the suprachiasmatic nucleus (SCN) is synchronized to the environmental light-dark cycle and ensures
Laura C. A. van der Zwet, Stephan Michel, Tom Deboer   +2 more
doaj   +1 more source

40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice

Cell Discovery
The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain parenchyma and eliminates metabolic waste.
Xiaoting Sun, Liliana Dias, Chenlei Peng, Ziyi Zhang, Haoting Ge, Zejun Wang, Jiayi Jin, Manli Jia, Tao Xu, Wei Guo, Wu Zheng, Yan He, Youru Wu, Xiaohong Cai, Paula Agostinho, Jia Qu, Rodrigo A. Cunha, Xuzhao Zhou, Ruiliang Bai, Jiang-fan Chen   +19 more
doaj   +1 more source

Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long‐duration spaceflight

Experimental Physiology, EarlyView.
Abstract Long‐duration spaceflight represents an extreme challenge, triggering adaptive responses including spaceflight‐associated neuro‐ocular syndrome, characterized by diminished visual acuity and ocular changes, which is a significant health risk for Mars missions.
Ge Tang, Steven Jillings, Ben Jeurissen, Elena Tomilovskaya, Inna Nosikova, Alexandra Ryabova, Ekaterina Pechenkova, Viktor Petrovichev, Ilya Rukavishnikov, Stefan Sunaert, Paul M. Parizel, Lyudmila Makovskaya, Valentin Sinitsyn, Jan Sijbers, Jitka Annen, Steven Laureys, Angelique Van Ombergen, Seyed‐Ahmad Ahmadi, Floris L. Wuyts, Peter zu Eulenburg   +19 more
wiley   +1 more source

Developing a Porcine Model to Study the Glymphatic System [PDF]

, 2022
The glymphatic system is a brain-wide solute clearance system that has developed in the brain to clear metabolic waste during sleep. This clearance is mediated by advective fluxes of cerebrospinal fluid (CSF) along perivascular spaces (PVS) and through ...
Bechet, Nicholas
core  

Coupling between global brain blood oxygen level‐dependent activity and cerebrospinal fluid dynamics in young endurance athletes

Experimental Physiology, EarlyView.
Abstract Cerebrospinal fluid (CSF) contributes to brain waste clearance through its coupling with cerebral haemodynamics. Aerobic exercise promotes brain health, but its influence on brain waste clearance remains unclear. This study examined the coupling between CSF and cerebral haemodynamics in endurance athletes. Fifteen young male endurance athletes
Daisuke Hoshi, Marina Fukuie, Ryota Asahara, Tsubasa Tomoto, David C. Zhu, Rong Zhang, Keigo Ohyama‐Byun, Seiji Maeda, Jun Sugawara, Takashi Tarumi   +9 more
wiley   +1 more source

[The glymphatic system - an overview]. Glymfatiska systemet – renar hjärnan från slaggprodukter [PDF]

, 2023
The glymphatic system as a concept was introduced a decade ago and the knowledge regarding the circulation of the cerebrospinal fluid has since been revised. The research of the glymphatic system is extensive today, but there are many knowledge gaps. The
Skoglund, Thomas,, Jakola, Asgeir Store,, Corell, Alba,   +2 more
core  

Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review

Frontiers in Neurology
The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system (CNS) of vertebrates that exploits the perivascular compartment between the vascular basement membrane (outermost wall of blood vessels) and astrocytic ...
Lichuan Zeng, Lichuan Zeng, Lichuan Zeng, Zihan Yin, Wei Li, Xiao Wang, Yaodan Zhang, Mingguo Xie, Ling Zhao   +8 more
doaj   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source