Results 101 to 110 of about 18,116,541 (240)

Glymphatic Dysfunction Across Neurological Disorders: Links to Neurodegeneration, Inflammaging, Gut–Brain Signaling, and Physiological Modulators

Biomedicines
The glymphatic system is a brain-wide perivascular network that facilitates cerebrospinal-fluid–interstitial-fluid exchange and the clearance of metabolic waste.
Konstantinos I. Voumvourakis, Nikolaos S. Thomaidis, Eleni Sideri, Georgios N. Papadimitropoulos, Chrysa Liadinioti, Georgios Tsivgoulis, Sotirios Tsiodras   +6 more
doaj   +1 more source

Alteration of the glymphatic system in Alzheimer disease compared to non-Alzheimer dementia: a single center PET/MRI study [PDF]

openBackground: The glymphatic system clears brain waste via cerebrospinal fluid (CSF) perivascular routes, maintaining homeostasis, but its function is disrupted in neurological disorders such as Alzheimer disease (AD).
DAL SANTO, ARIANNA
core  

Investigating the Link Between Objective Sleep Metrics and Cerebral Small Vessel Disease in a Population‐Based Cohort

Journal of Sleep Research, EarlyView.
ABSTRACT Cerebral small vessel disease (CSVD), a disorder that affects the cerebral microvasculature, is commonly associated with aging and may contribute to dementia and stroke. Increasing evidence suggests a link between CSVD and sleep disturbances, but the association remains poorly understood.
Mareike Ludwig, Arne Böttcher, Marvin Petersen, Felix Leonard Nägele, Maximilian Schell, Jacob Friedrich Clausen, Götz Thomalla, Ines Schäfer, Alena Haack, Christian Betz, Anna Sophie Hoffmann, Bastian Cheng   +11 more
wiley   +1 more source

“Glymphatic” Neurodegeneration: Is Sleep the Missing Key?

Clinical and Translational Neuroscience
Robust evidence suggests that the glymphatic system plays a key role in preserving brain health. Indeed, its activity in maintaining homeostasis by clearing neurotoxic proteins such as beta-amyloid from the human brain is essential.
Luigi Ferini-Strambi, Maria Salsone
doaj   +1 more source

From mouth to brain: Linking periodontal and peri‐implant dysbiosis to systemic inflammation and neuropathology

Periodontology 2000, EarlyView.
Abstract Background/Aim Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. Materials and Methods A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was ...
Emilio A. Cafferata, Frank Schwarz, Jaime Díaz‐Zúñiga, Alpdogan Kantarci   +3 more
wiley   +1 more source

Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline

Experimental Physiology, EarlyView.
Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley   +1 more source

Brain Glymphatic System

, 2018
Táto práca je venovaná problematike glymfatického systému, ako potenciálneho mechanizmu pre odstránenie metabolického odpadu z mozgu. Jedná sa o kapitoly, ktoré zahŕňajú základné poznatky o anatómii a funkcii centrálneho nervového systému a mozgu, objav ...
Záhorská, Alexandra
core   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review

Frontiers in Neurology
The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system (CNS) of vertebrates that exploits the perivascular compartment between the vascular basement membrane (outermost wall of blood vessels) and astrocytic ...
Lichuan Zeng, Lichuan Zeng, Lichuan Zeng, Zihan Yin, Wei Li, Xiao Wang, Yaodan Zhang, Mingguo Xie, Ling Zhao   +8 more
doaj   +1 more source

The Ocular Glymphatic System—Current Understanding and Future Perspectives

The ocular glymphatic system subserves the bidirectional polarized fluid transport in the optic nerve, whereby cerebrospinal fluid from the brain is directed along periarterial spaces towards the eye, and fluid from the retina is directed along ...
Christine Delle, Delle, Christine, Wang, Xiaowei, Maiken Nedergaard, Nedergaard, Maiken, Xiaowei Wang   +5 more
core   +1 more source