Results 101 to 110 of about 24,909,638 (279)

Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration

Cells
The key to the effective treatment of neurodegenerative disorders is a thorough understanding of their pathomechanism. Neurodegeneration and neuroinflammation are mutually propelling brain processes.
Stanisław Szlufik, Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski   +3 more
doaj   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Sleep, circadian rhythms, and the pathogenesis of Alzheimer Disease [PDF]

Disturbances in the sleep–wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), and they have generally been considered as late consequences of the neurodegenerative processes.
Holtzman, David M, Musiek, Erik S, Xiong, David D   +2 more
core   +1 more source

Phase coupling between eye and brain pulsations is bidirectional and modulated by the parasympathetic system – An fMREye study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Physiological pulsations driven by cardiac, respiratory, and vasomotor activity are essential for solute transport within perivascular and perineural cerebrospinal fluid (CSF) pathways that support brain and eye clearance systems. Previous studies have shown that parasympathetic blockade significantly reduces ocular pulsation power and
Ebrahimi Seyed‐Mohsen, Väyrynen Tommi, Huotari Niko, Saarela Ville, Honkamo Marja, Helakari Heta, Järvelä Matti, Korhonen Vesa, Raitamaa Lauri, Kiviniemi Vesa   +9 more
wiley   +1 more source

Modeling Chronic Traumatic Encephalopathy: The Way Forward for Future Discovery [PDF]

Despite the extensive media coverage associated with the diagnosis of chronic traumatic encephalopathy (CTE), our fundamental understanding of the disease pathophysiology remains in its infancy.
Anthony L. Petraglia, Aric F. Logsdon, Brandon P. Lucke-Wold, Charles L. Rosen, Jason D. Huber, John M. Lee, Julian E. Bailes, Matthew J. Robson, Matthew L. Dashnaw, Ryan C. Turner   +9 more
core   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Increased glymphatic system activity and thalamic vulnerability in drug-naive somatic depression: Evidenced by DTI-ALPS index

NeuroImage: Clinical
Highlights • Increased DTI-ALPS index observed in MDD, especially in somatic depression patients.• DTI-ALPS index positively correlated with volume of thalamus nuclei, mainly in somatic depression patients.• Findings suggest thalamus vulnerability to ...
Z. Deng, Wei Wang, Zhaowen Nie, Simeng Ma, Enqi Zhou, Xinhui Xie, Qian Gong, L. Yao, Lihong Bu, Lijun Kang, Zhongchun Liu   +10 more
semanticscholar   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, EarlyView.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source

Glucocorticoid signalling coordinating circadian rhythms between the glymphatic system and sleep contributes to brain health [PDF]

Exploration of Endocrine and Metabolic Diseases
Circadian rhythms are present in almost every cell of the body and play important roles in various physiological processes. The central circadian clock in the suprachiasmatic nucleus (SCN) is synchronized to the environmental light-dark cycle and ensures
Laura C. A. van der Zwet, Stephan Michel, Tom Deboer   +2 more
doaj   +1 more source

Parkinson’s disease with possible REM sleep behavior disorder correlated with more severe glymphatic system dysfunction

npj Parkinson's Disease
This study aimed to evaluate the glymphatic system activity in Parkinson’s disease (PD) with and without rapid eye movement sleep behavior disorder (RBD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods.
Xinxin Ma, Yueying Liu, Miaoxian Xie, Chunmei Li, Xinyang Li, Dandan Shang, Min Chen, Haibo Chen, Wen Su   +8 more
semanticscholar   +1 more source