Results 111 to 120 of about 18,116,541 (240)

The Association between Glymphatic System and Perivascular Macrophages in Brain Waste Clearance

Diagnostics
The glymphatic system suggests the convective bulk flow of cerebrospinal fluid (CSF) through perivascular spaces and the interstitial spaces of the brain parenchyma for the rapid removal of toxic waste solutes from the brain.
Jasleen Kaur, Edward D. Boyd, Guangliang Ding, Li Zhang, Hao Luo, Qingjiang Li, Lian Li, Min Wei, Julie Landschoot-Ward, Michael Chopp, Zhenggang Zhang, Quan Jiang   +11 more
doaj   +1 more source

The glymphatic system for neurosurgeons: a scoping review

Neurosurgical Review
Abstract The discovery of the glymphatic system has revolutionized our understanding of cerebrospinal fluid (CSF) circulation and interstitial waste clearance in the brain. This scoping review aims to synthesize the current literature on the glymphatic system’s role in neurosurgical conditions and its potential as a therapeutic target.
Mohammad Al Masri, Alba Corell, Isak Michaëlsson, Asgeir S. Jakola, Thomas Skoglund   +4 more
openaire   +2 more sources

Coupling between global brain blood oxygen level‐dependent activity and cerebrospinal fluid dynamics in young endurance athletes

Experimental Physiology, EarlyView.
Abstract Cerebrospinal fluid (CSF) contributes to brain waste clearance through its coupling with cerebral haemodynamics. Aerobic exercise promotes brain health, but its influence on brain waste clearance remains unclear. This study examined the coupling between CSF and cerebral haemodynamics in endurance athletes. Fifteen young male endurance athletes
Daisuke Hoshi, Marina Fukuie, Ryota Asahara, Tsubasa Tomoto, David C. Zhu, Rong Zhang, Keigo Ohyama‐Byun, Seiji Maeda, Jun Sugawara, Takashi Tarumi   +9 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

MRI investigation of glymphatic responses to Gd-DTPA infusion rates

, 2018
The glymphatic system is a newly identified waste clearance pathway in brain discovered and investigated predominately using in vivo two-photon confocal microscopy. Magnetic resonance imaging (MRI), in contrast to two-photon confocal microscopy, provides
Davoodi-Bojd, Esmaeil, Li, Qingjiang, Zhang, Zhenggang, Zhang, Li, Ding, Guangliang, Li, Lian, Jiang, Quan, Chopp, Michael   +7 more
core   +2 more sources

Cerebral blood flow in conscious rats and implications for therapeutic interventions

Experimental Physiology, EarlyView.
Abstract Cerebral blood flow (CBF) often becomes compromised in patients suffering from cardiovascular diseases, increasing the risk of neurodegenerative disease and vascular dementia. There is an urgent need for treatments to address cardiovascular risk without compromising brain perfusion, yet the impact of many existing treatments on CBF are not ...
Tonja W. Emans, Courtney R. Brighouse, Jack T. Sloan, Fiona D. McBryde   +3 more
wiley   +1 more source

Thermoregulatory and plasma neurobiomarker responses to heat tolerance assessment in exertional heat illness and matched controls

Experimental Physiology, EarlyView.
Abstract Exercise in the heat and elevated tissue temperature are associated with neuronal stress and changes in blood–brain barrier (BBB) function. More severe thermal insult may manifest as exertional heat illness (EHI) and complication by central nervous system (CNS) dysfunction may persist post‐EHI.
Tom W. Palin, Jo Corbett, Lisa J. Hill, David R. Woods, Alex A. M. Gould, Barney Wainwright, James A. Roberts, Chloe N. Thomas, Daniel Snape, Carol House, Omar Tayari, Richard J. Elsworthy, James L. Mitchell, Andrew J. Roberts, John P. O'Hara, Michael J. Stacey   +15 more
wiley   +1 more source

Hypothalamic Neurochemical and Microglial Suppression in Long‐Standing Human Hibernation‐Like Syndrome

Neuropathology and Applied Neurobiology, Volume 52, Issue 6, December 2026.
A rare case of a human hibernation‐like syndrome was associated with preserved hypothalamic anatomy but profound suppression of neuroendocrine and circadian neuropeptide systems. Marked reductions in synaptic and microglial immunoreactivity suggest a suppressed hypothalamic neuron–glial network, despite preserved astrocytic markers, myelination and ...
Wei Jiang, Andries Kalsbeek, Roelof A. Hut, Dick F. Swaab, Chun‐Xia Yi   +4 more
wiley   +1 more source

Role of the glymphatic system in ageing and diabetes mellitus impaired cognitive function

, 2019
Diabetes mellitus (DM) is a common metabolic disease in the middle-aged and older population, and is associated with cognitive impairment and an increased risk of developing dementia.
Zhang, Zhenggang, Zhang, Li, Jiang, Quan, Chopp, Michael   +3 more
core   +1 more source

The Glymphatic System: A New Player in Ocular Diseases? [PDF]

Investigative Opthalmology & Visual Science, 2016
Wostyn, Peter, De Groot, Veva, Van Dam, Debby, Audenaert, Kurt, De Deyn, Peter Paul, Killer, Hanspeter Esriel   +5 more
openaire   +3 more sources