Results 111 to 120 of about 17,183,881 (176)

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2309-2320, November 2026.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

Quantifying Cardiac, Respiratory, and Low Frequency Components of CSF Motion From fMRI Inflow Effects

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1916-1928, October 2026.
ABSTRACT Purpose Cerebrospinal fluid (CSF) flow oscillations have emerged as a potentially important marker related to brain clearance, but their acquisition often relies on specialized imaging MRI sequences. The purpose of this work was to enable quantitative assessment of CSF flow associated with cardiac, respiratory, and low‐frequency cycles using ...
Pontus Söderström, Cecilia Björnfot, Britt M. Andersson, Jan Malm, Anders Eklund, Anders Wåhlin   +5 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1780-1790, September 2026.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

Are infraslow oscillations the missing link between sleep and Alzheimer's?

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Locus coeruleus (LC) and glymphatic dysfunction have been linked both to Alzheimer's disease (AD) and, recently, to infraslow oscillation (ISO) in sleep spindle (sigma) activity (ISO). Here we hypothesize ISO integrity is a critical link between sleep and AD.
Demetrio Grollero, Victoria Gabb, Jonathan Blackman, Amanda Heslegrave, Luisa de Vivo, Elizabeth Coulthard, Michele Bellesi   +6 more
wiley   +1 more source

Neurologic symptoms as a hallmark of glymphatic alteration in recovered patients with COVID-19

BMC Neurology
Background The glymphatic system is a glial-based perivascular network that facilitates the clearance of metabolic waste from the brain. Dysfunction of the glymphatic system, along with neurological symptoms such as cognitive deficits and olfactory ...
Minhoe Kim, Kyung Hoon Lee, Ji Su Ko, Myung Sub Kim, Kyu Sung Choi, Jiwon Seo, Minchul Kim   +6 more
doaj   +1 more source

Neurobiological mechanisms of 40‐Hz stimulation in Alzheimer's disease: evidence, heterogeneity, and constraints

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract Early disruption of gamma oscillations is increasingly recognized as a contributor to neurodegeneration and cognitive decline in Alzheimer's disease (AD), positioning 40‐Hz stimulation as a promising neuromodulatory strategy. However, its neurophysiological and cognitive effects remain highly variable across studies, underscoring the need for ...
Lin Qi, Weiye Wang, Reema Abdullah, Yilei Zhao, Zhibin Wang, Yi Tang, Benyan Luo, Guoping Peng   +7 more
wiley   +1 more source

Water and wisdom: Hydration as a defence against dementia

Experimental Physiology, EarlyView.
David C. Byfield, Damian M. Bailey
wiley   +1 more source

Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION We tested whether quantitative transport mapping (QTM)‐derived perfusion velocity would detect earlier and more sex‐specific microvascular alterations than cerebral blood flow (CBF) across the Alzheimer's disease (AD) continuum.
Manxi Xu, Yian Gao, Peiling Ou, Haoyu Yang, Jia Wang, Wulong Liu, Ni Shu, Yu Sun, Liping Fu, Lidia Glodzik, Tracy A Butler, Gloria C Chaing, Yi Li, Yi Wang, Liangdong Zhou, Guolin Ma   +15 more
wiley   +1 more source

The Glymphatic System: A New Player in Ocular Diseases? [PDF]

Investigative Opthalmology & Visual Science, 2016
Wostyn, Peter, De Groot, Veva, Van Dam, Debby, Audenaert, Kurt, De Deyn, Peter Paul, Killer, Hanspeter Esriel   +5 more
openaire   +3 more sources

Shared genetic architecture between DTI‐ALPS traits and neurodegenerative diseases

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear. METHODS By integrating genome‐wide association datasets for three DTI‐ALPS traits and seven NDDs, we quantified polygenic overlap using MiXeR ...
Hong Zhou, Jialin Deng, Qian Wu, Yule Zeng, Tianyao Wang, Jiayi Wu, Xiaomei Duan, Beisha Tang, Xinhua Wei, Lu He, Feng Liu   +10 more
wiley   +1 more source