Results 111 to 120 of about 12,211 (230)

Microglia synchronizes with the circadian rhythm of the glymphatic system and modulates glymphatic system function

IUBMB Life
AbstractMicroglia, as immune cells in the central nervous system, possess the ability to adapt morphologically and functionally to their environment. Glymphatic system, the principal waste clearance system in the brain, exhibits circadian rhythms. However, the impact of microglia on the glymphatic system function remains unknown.
Ting Yang, Yan Tang, Xinghua Liu, Song Gong, Ensheng Yao   +4 more
openaire   +2 more sources

Phenotypic Variability in Slow‐Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity

Journal of Sleep Research, EarlyView.
ABSTRACT Slow‐wave sleep (SWS; stage N3) is often reported as reduced in depression, yet variability across depressive phenotypes remains poorly characterised. This study aimed to determine whether N3 architecture—proportion, duration, and latency—identifies clinically distinct profiles in major depressive episode (MDE).
Antoine Salmeron, Pierre A. Geoffroy, Lily Vissouze, Jeanne Leseur, Heloise Rach, Michel Lejoyeux, Justine Frija, Marie Pia d’Ortho, Julia Maruani   +8 more
wiley   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source

Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline

Experimental Physiology, EarlyView.
Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley   +1 more source

Dilated Virchow-Robin spaces in primary open-angle glaucoma : a biomarker of glymphatic waste clearance dysfunction? [PDF]

, 2016
Audenaert, Kurt, De Deyn, Peter Paul, De Groot, Veva, Killer, Hanspeter Esriel, Van Dam, Debby, Wostyn, Peter   +5 more
core   +6 more sources

Glucocorticoid signalling coordinating circadian rhythms between the glymphatic system and sleep contributes to brain health [PDF]

Exploration of Endocrine and Metabolic Diseases
Circadian rhythms are present in almost every cell of the body and play important roles in various physiological processes. The central circadian clock in the suprachiasmatic nucleus (SCN) is synchronized to the environmental light-dark cycle and ensures
Laura C. A. van der Zwet, Stephan Michel, Tom Deboer   +2 more
doaj   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source

40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice

Cell Discovery
The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain parenchyma and eliminates metabolic waste.
Xiaoting Sun, Liliana Dias, Chenlei Peng, Ziyi Zhang, Haoting Ge, Zejun Wang, Jiayi Jin, Manli Jia, Tao Xu, Wei Guo, Wu Zheng, Yan He, Youru Wu, Xiaohong Cai, Paula Agostinho, Jia Qu, Rodrigo A. Cunha, Xuzhao Zhou, Ruiliang Bai, Jiang-fan Chen   +19 more
doaj   +1 more source

Sleep and Academic Performance : What students and faculty need to know [PDF]

, 2015
ここ数10年の間における研究をとおして,アカデミック・パフォーマンスにおける睡眠の役割と重要性への理解が進んできた。睡眠の量および質という両側面が,人間の記憶機能と神経系の働きに直接的かつ重大な影響を持つことが明らかになってきている。本稿では,最近の研究文献を多角的かつ複合的に再考し,アカデミック・パフォーマンスを向上させるためには睡眠の質を高めることが重要かつ不可欠であるという提言を試みる。During the past few decades much progress has been made ...
SNYDER Steven M., Steven M. SNYDER, スナイダー スティーブン   +2 more
core  

Physiological cerebrospinal fluid interactions between brain and eye structures are altered after long‐duration spaceflight

Experimental Physiology, EarlyView.
Abstract Long‐duration spaceflight represents an extreme challenge, triggering adaptive responses including spaceflight‐associated neuro‐ocular syndrome, characterized by diminished visual acuity and ocular changes, which is a significant health risk for Mars missions.
Ge Tang, Steven Jillings, Ben Jeurissen, Elena Tomilovskaya, Inna Nosikova, Alexandra Ryabova, Ekaterina Pechenkova, Viktor Petrovichev, Ilya Rukavishnikov, Stefan Sunaert, Paul M. Parizel, Lyudmila Makovskaya, Valentin Sinitsyn, Jan Sijbers, Jitka Annen, Steven Laureys, Angelique Van Ombergen, Seyed‐Ahmad Ahmadi, Floris L. Wuyts, Peter zu Eulenburg   +19 more
wiley   +1 more source