Results 131 to 140 of about 18,116,541 (240)

Glymphatic activity is linked to the synaptic vesicle cycle pathway in frontotemporal dementia: A metabolomics study

Neurobiology of Disease
Background: Emerging evidence implicating glymphatic dysfunction contributes to the pathogenesis of frontotemporal dementia (FTD). However, the pathway correlated to glymphatic function in FTD remains poorly understood.
Min Chu, Ailing Yue, Haitian Nan, Hong Ye, Miao Qu, Liyong Wu   +5 more
doaj   +1 more source

Assessment of Glymphatic System in epilepsy: A systematic review and meta ana

A systematic review and meta analysis on glymphatic system assessment based on the DTI in different types of ...
Maryam Moghbel Baerz
core   +1 more source

Choroid Plexus Enlargement and USPIO‐Based Inflammatory Feature in Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2078-2087, October 2026.
ABSTRACT Objective The choroid plexus (CP) is a key component of the blood–cerebrospinal fluid barrier (BCSFB), but its mechanism of action in cerebral small vessel disease (CSVD) remains unclear. This study investigated CP volume (CPV) alterations and their association with conventional imaging markers in CSVD and explored the underlying role of ...
Yongqiang Qu, Xiaoning Ren, Cuihua Fan, Chun Li, Lijie Zhang, Zaiqiang Zhang, Shaowu Li, Zhongmeng Lai, Bin Cai, Ying Fu, Yi Lin, Zhibao Zhu   +11 more
wiley   +1 more source

Clinical magnetic resonance imaging evaluation of glymphatic function

The glymphatic system is a system of specialized perivascular spaces in the brain that facilitates removal of toxic waste solutes from the brain. Evaluation of glymphatic system function by means of magnetic resonance imaging (MRI) has thus far been ...
Kaur, Jasleen, Ding, Guangliang, Jiang, Quan, Boyd, Edward D, Chopp, Michael   +4 more
core  

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, Volume 13, Issue 57, 14 October 2026.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

Exposome‐wide association study and predictive risk score for incident Alzheimer's disease and related dementias

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Environmental exposures contribute substantially to Alzheimer's disease and related dementias (ADRD), yet comprehensive exposome‐wide investigations systematically evaluating multi‐domain environmental factors remain limited and lacking utility for precision medicine. METHODS We conducted an exposome‐wide association study (ExWAS)
Chenshuang Li, Chenxu Zhao, Yiqun Lan, Randall J Ellis, Shakson Isaac, Sai Zhang, Gary W. Miller, Yi Sun, Shalini Jain, Hariom Yadav, Peng Gao, Chirag J Patel   +11 more
wiley   +1 more source

The right temperature at the right time: A framework for understanding thermoregulatory pathophysiology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley   +1 more source

Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation, neurodegeneration, and cognitive decline.
James D. LeFevre, Yukti Vyas, Angela L. Jefferson   +2 more
wiley   +1 more source

Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression

Annals of Neurology, Volume 100, Issue 4, Page 695-708, October 2026.
Objective Magnetic resonance imaging (MRI)‐visible enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (SVD) and aging, processes implicated in both neurodegenerative and cerebrovascular pathologies. However, longitudinal positron emission tomography (PET) studies examining PVS as a mechanism underlying Alzheimer's disease ...
Audrey Low, Jeffrey L. Gunter, Mingzhao Hu, Sheelakumari Raghavan, Scott A. Przybelski, Christopher G. Schwarz, Kejal Kantarci, Val J. Lowe, Ronald C. Petersen, Jonathan Graff‐Radford, Clifford R. Jack Jr, Prashanthi Vemuri   +11 more
wiley   +1 more source

The glymphatic system in oncology : from the perspective of a radiation oncologist

The brain and spinal cord, which constitute the central nervous system, were historically considered immune-privileged sites, as it was believed they lacked an equivalent to the systemic lymphatic system.
Oda, Seitaro, Iima, Mami, Watabe, Tadashi, Saida, Tsukasa, Kawamura, Mariko, Ito, Rintaro, Honda, Maya, Sugawara, Shunsuke, Hirata, Kenji, Nishioka, Kentaro, Yanagawa, Masahiro, Ueda, Daiju, Sofue, Keitaro, Kurokawa, Ryo, Naganawa, Shinji, Ide, Satoru, Sakata, Akihiko, Takumi, Koji   +17 more
core   +1 more source