Results 141 to 150 of about 18,116,541 (240)

Spotlight commentary: Addressing the persistent problem of benzodiazepine overuse, time for clinical, educational and AI‐driven reform

British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3703-3706, November 2026.
Jakša Vukojević, Luka Horvat, Vito Papić, Andrija Štajduhar   +3 more
wiley   +1 more source

Association of Glymphatic Imaging Markers With Clinical Outcomes and Cerebral Small Vessel Disease Burden After Intracerebral Hemorrhage

Brain and Behavior, Volume 16, Issue 10, October 2026.
In patients with intracerebral hemorrhage, higher free water fraction in contralateral white matter was associated with lower odds of functional independence and greater WMH burden. These associations did not remain statistically significant after FDR correction, and the FW–outcome association was nonsignificant after adjustment for WMH burden ...
Xiao Hu, Zuoqiao Li, Zijie Wang, Yingmei Zhang, Mengqiu Zhang, Sijia Liu, Fan Chen, Jianshuo Shao, Longsheng Wang, Qi Li   +9 more
wiley   +1 more source

The Role of Glymphatic Clearance in Affective Decision‐Making in Adolescents with Non‐Suicidal Self‐Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In adolescents with non‐suicidal self‐injury (NSSI), characterized by sleep disturbances and metabolic burden, a disease‐specific, compensatory up‐regulation of glymphatic function (stronger gBOLD‐CSF coupling) selectively supports “hot” (affective) cognition while leaving “cold” (executive) cognition unlinked, functioning as a pathological buffer ...
Hongping Wang, Jiahua Zhang, Ruizi Pan, Xiaoqian Ye, Rong Wang, Ke Lv, Yue Yu, Qianqian Li, Ting Zhang, Dongpeng Wu, Dai Zhang, Yanghua Tian   +11 more
wiley   +1 more source

The glymphatic system and multiple sclerosis: An evolving connection

Multiple sclerosis (MS) is a complex autoimmune disorder that affects the central nervous system, resulting in demyelination and an array of neurological manifestations.
Alghanimy, Alaa, Work, Lorraine M., Holmes, William M.   +2 more
core   +1 more source

PANoptosis In Microglia and Neurons Following Traumatic CNS Injury: A Systematic Review of Pathological Features and Therapeutic Implications

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Following traumatic CNS injury, PANoptosis is activated in microglia and neurons, with microglia–neuron crosstalk serving as a key feature of this process. The PANoptosome sensors ZBP1 and NLRP12, together with the adaptor ASC, activate downstream executioner proteins to drive PANoptosis.
Zhusheng Feng, Yingnan Fan, Tianshu Du, Peipei Huang, Yuqin Ye, Junjie Li   +5 more
wiley   +1 more source

“Hypodense Holes” and the Ocular Glymphatic System: Author Response: “Black Holes” and the Ocular Glymphatic System [PDF]

Investigative Opthalmology & Visual Science, 2017
Wostyn, Peter, De Groot, Veva, Van Dam, Debby, Audenaert, Kurt, De Deyn, Peter Paul, Esriel Killer, Hanspeter   +5 more
openaire   +4 more sources

Cerebral Artery Stenosis, Glymphatic Dysfunction, and Cognitive Trajectories: A Longitudinal Cohort Study of Community‐Dwelling Older Adults

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
DTI‐ALPS and FW‐WM significantly mediated the association between stenosis burden and baseline MMSE. Participants with both stenosis and impaired glymphatic function showed the most rapid MMSE decline and a higher risk of CDR‐SB worsening than those with stenosis but preserved glymphatic function or those without stenosis.
Weizhuang Yuan, Xingyang Niu, Linfang Lan, Xinran Chen   +3 more
wiley   +1 more source

The Glymphatic System in α-Synucleinopathies. [PDF]

Yonsei Med J
Jeong SH, Chung SJ, Lee PH.
europepmc   +1 more source

Multimodal Characterization of APOE ε4‐Associated Neurovascular Heterogeneity Using Retinal, Plasma, and Neuroimaging Biomarkers in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
The LASSO and logistic regression model integrate neuroimaging measures and retinal vascular biomarkers to identify key predictors of APOE ε4 status, improving genotype‐specific stratification. The model's calibration curve and decision curve analysis demonstrate improved discrimination and clinical utility when retinal vascular data are integrated ...
Haoran Cheng, Huwei Xia, Youjie Wang, Le Cao, Suqing Hu, Huayan Wang, William Robert Kwapong, Zhen Wang, Caiyun Wen   +8 more
wiley   +1 more source

WONOEP appraisal: Biomarkers and treatment strategies beyond the synapse

Epilepsia, Volume 67, Issue 10, Page 5026-5041, October 2026.
Abstract Epilepsy is a heterogeneous neurological disorder affecting more than 70 million people worldwide, posing significant challenges for clinicians due to its complex etiology, diverse manifestations, variable treatment responses, and the inability to predict seizures or disease onset reliably.
Mirte Scheper, Zining Liu, Aristea S. Galanopoulou, Gernot Hlauschek, Benjamin Sinclair, Wai Lam Leung, Stefanie Dedeurwaerdere, Elisabeth Doran, Solomon L. Moshé, David C. Henshall, Ozlem Akman, Pablo M. Casillas‐Espinosa   +11 more
wiley   +1 more source