Results 161 to 170 of about 24,909,638 (279)

Influence of an AQP4 haplotype and sleep duration on early Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Aquaporin‐4 (AQP4) is thought to facilitate Alzheimer's disease (AD) protein clearance during sleep. We examined whether AQP4 genetic variation was associated with AD pathology or modified the association between sleep duration and AD biomarkers.
Emma L. Palatsides, Stephanie Yiallourou, Dibya Himali, Marina G. Cavuoto, Andrée‐Ann Baril, Qiong Yang, Gina M. Peloso, Joanne Ryan, Georges El Fakhri, Saptaparni Ghosh, Emma Thibault, Charles S. DeCarli, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri, Jayandra J. Himali, Matthew P. Pase   +16 more
wiley   +1 more source

Stress, stress systems, and Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract Stress is increasingly recognized as an important, modifiable factor for Alzheimer's disease (AD), yet its roles in initiation, progression, and outcomes remain incompletely elucidated. Epidemiologic studies link chronic stress, early‐life adversity, and trauma to increased AD risk, while experimental models have uncovered mechanisms by which ...
Stephanie G. Eberly, Chayarndorn Phumsatitpong, Catherine E. Munro, Thomas C. Neylan, Daniela Kaufer, Alexander J. Ehrenberg   +5 more
wiley   +1 more source

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, Volume 101, Issue 3, Page 1491-1510, June 2026.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source

Foreign body responses in central nervous system mimic natural wound responses and alter biomaterial functions [PDF]

Biomaterials hold promise for diverse therapeutic applications in the central nervous system (CNS). Little is known about molecular factors that determine CNS foreign body responses (FBRs) in vivo , or about how such responses influence biomaterial ...
Ao, Yan, Deming, Timothy, Kim, Jae, O’Shea, Timothy, Sofroniew, Michael, Wollenberg, Alexander   +5 more
core  

Acute Lung Injury: From Molecular Circuits to System‐Level Therapeutics

MedComm, Volume 7, Issue 6, June 2026.
This visual summary illustrates the paradigm shift from linear pathways to network medicine in ALI. Three interconnected circuits—innate immunity, immunometabolism, and cell death (PANoptosis)—drive disease progression under multiorgan crosstalk (gut–lung, brain–lung).
Yaoli Hou, Sheng He, Lili He, Kun Liu, Wen Tang, Deming Wang, Jing Gui, Zhiying Zeng, Yan Wang, Wenjie Liu, Ren Jing   +10 more
wiley   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

Dilated Virchow-Robin spaces in primary open-angle glaucoma : a biomarker of glymphatic waste clearance dysfunction? [PDF]

Audenaert, Kurt, De Deyn, Peter Paul, De Groot, Veva, Killer, Hanspeter Esriel, Van Dam, Debby, Wostyn, Peter   +5 more
core   +1 more source

Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3409-3415, June 2026.
ABSTRACT Purpose The aim was to estimate T1 relaxivity of gadobutrol and gadoteric acid in cerebrospinal fluid (CSF) at 3T, to support research on CSF‐flow and the glymphatic system in humans utilizing T1 mapping after intrathecal injection. Methods Using a phantom, relaxivity was estimated for gadobutrol and gadoteric acid in lumbar CSF and an ...
Sofia Behndig, Anders Garpebring, Daniel Dahlgren Lindström, Jan Malm, Anders Wåhlin, Anders Eklund   +5 more
wiley   +1 more source

2014 Behavioral Health and Performance Standing Review Panel [PDF]

The 2014 Behavioral Health and Performance (BHP) Standing Review Panel (from here on referred to as the SRP) met for a site visit in Houston, TX on December 17 - 18, 2014.
Balkin, Thomas, Bono, Joyce, Caldwell, John, Dimsdale, Joel, Joiner, Thomas, Leon, Gloria, Paulus, Martin, Steinberg, Susan, Zaccaro, Stephen   +8 more
core  

Rapid Tissue‐CSF Water Exchange in the Human Brain Revealed by Magnetization Transfer Indirect Spin Labeling

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3270-3283, June 2026.
ABSTRACT Purpose To apply the Magnetization Transfer Indirect Spin Labeling (MISL) MRI technique for quantifying tissue‐CSF water exchange in the human brain, and to investigate its utility in (1) evaluating tissue‐CSF water exchange within perivascular spaces (PVS), and (2) characterizing altered water exchange dynamics in pathologic conditions ...
Yihan Wu, Kexin Wang, Licheng Ju, Anna Li, Qin Qin, Feng Xu, Doris D. M. Lin, Lawrence Kleinberg, Jiadi Xu   +8 more
wiley   +1 more source