Results 161 to 170 of about 18,116,541 (240)

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels. [PDF]

Aging Cell
Song B, Wang W, Liu S, Jin X, Qi Y, Li M, Yue D, Liu Y, Li X, Yin L, Feng L.   +10 more
europepmc   +1 more source

Hypothalamus Participates in Peripheral Sympathetic Hyperactivity After Acute Brain Injury by Regulating Trhr M6A Modification

MedComm, Volume 7, Issue 10, October 2026.
In acute brain injury (TBI/ICH), sympathetic hyperactivity is driven by hypothalamic FTO upregulation. FTO demethylates Trhr, blocking m6A‐YTHDF2‐dependent degradation, which stabilizes Trhr mRNA and increases neuronal sensitivity to TRH. Restoring FTO or Trhr alleviates sympathetic hyperactivity, offering a potential target for managing autonomic ...
Maoxing Fei, Handong Wang, Chaochao Gao, Shiqiao Luo, Xiwen Huang, Yanling Han, Mengliang Zhou, Zhenxing Li   +7 more
wiley   +1 more source

Glymphatic System Reconstruction in the Management of Alzheimer’s Disease

Iranian Journal of Neurosurgery
Alzheimer’s disease (AD) is a major public health challenge. The exact cause of AD is unknown, but it is characterized by progressive impairment in cognitive and memory functions and pathological changes in the brain, such as aggregation of two main ...
Ashkan Asgari Gashtrodkhani, Roxana Kaveh, Zoheir Reihanian, Shahrokh Yousefzadeh-Chabok, Sasan Andalib   +4 more
doaj  

The Glymphatic System and Neurosurgery: A Comprehensive Narrative Review of Current Concepts and Future Directions. [PDF]

J Clin Med
Çetinkaya K, Ünsal Y.
europepmc   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

New Directions in Migraine Pathophysiology: The Glymphatic System and PACAP. [PDF]

Life (Basel)
Cuciureanu DI, Bistriceanu CE, Vulpoi GA, Constantinescu V, Blajuta DL, Nădejde AM, Antochi F, Roceanu AM.   +7 more
europepmc   +1 more source

Quantifying Cardiac, Respiratory, and Low Frequency Components of CSF Motion From fMRI Inflow Effects

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1916-1928, October 2026.
ABSTRACT Purpose Cerebrospinal fluid (CSF) flow oscillations have emerged as a potentially important marker related to brain clearance, but their acquisition often relies on specialized imaging MRI sequences. The purpose of this work was to enable quantitative assessment of CSF flow associated with cardiac, respiratory, and low‐frequency cycles using ...
Pontus Söderström, Cecilia Björnfot, Britt M. Andersson, Jan Malm, Anders Eklund, Anders Wåhlin   +5 more
wiley   +1 more source

Glymphatic System Dysfunction in Epilepsy: Clinical and Translational Perspectives. [PDF]

Epilepsy Curr
Lee DA, Lee HJ, Park KM.
europepmc   +1 more source

Interview with Ruotong Chen, recipient of the 2026 Epilepsia Open Prize for Clinical Research

Epilepsia Open, Volume 11, Issue 5, Page 1880-1882, October 2026.
Merab Kokaia, Piero Perucca
wiley   +1 more source