Results 121 to 130 of about 24,909,638 (279)

Phenotypic Variability in Slow‐Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity

Journal of Sleep Research, EarlyView.
ABSTRACT Slow‐wave sleep (SWS; stage N3) is often reported as reduced in depression, yet variability across depressive phenotypes remains poorly characterised. This study aimed to determine whether N3 architecture—proportion, duration, and latency—identifies clinically distinct profiles in major depressive episode (MDE).
Antoine Salmeron, Pierre A. Geoffroy, Lily Vissouze, Jeanne Leseur, Heloise Rach, Michel Lejoyeux, Justine Frija, Marie Pia d’Ortho, Julia Maruani   +8 more
wiley   +1 more source

“Glymphatic” Neurodegeneration: Is Sleep the Missing Key?

Clinical and Translational Neuroscience
Robust evidence suggests that the glymphatic system plays a key role in preserving brain health. Indeed, its activity in maintaining homeostasis by clearing neurotoxic proteins such as beta-amyloid from the human brain is essential.
Luigi Ferini-Strambi, Maria Salsone
doaj   +1 more source

Cardiovascular Responses to Natural and Auditory Evoked Slow Waves Predict Post‐Sleep Cardiac Function

Journal of Sleep Research, EarlyView.
ABSTRACT The importance of sleep as a key component of cardiovascular health has been increasingly recognized. Our previous research demonstrated that auditory‐enhanced slow waves increase cardiac function, but the underlying mechanisms behind these beneficial effects remain uncertain. In this study, we examined the influence of two types of slow waves
Giulia Alessandrelli, Stephanie Huwiler, Giulio Bernardi, Manuel Carro‐Domínguez, Fabia Stich, Rossella Sala, Florent Aziri, Anna Trippel, Susanne Markendorf, David Niederseer, Philipp Bohm, Pietro Cerveri, Francesca Siclari, Reto Huber, Nicole Wenderoth, Christian Schmied, Caroline Lustenberger   +16 more
wiley   +1 more source

Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review

Frontiers in Neurology
The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system (CNS) of vertebrates that exploits the perivascular compartment between the vascular basement membrane (outermost wall of blood vessels) and astrocytic ...
Lichuan Zeng, Lichuan Zeng, Lichuan Zeng, Zihan Yin, Wei Li, Xiao Wang, Yaodan Zhang, Mingguo Xie, Ling Zhao   +8 more
doaj   +1 more source

Central and peripheral circadian clocks and their role in Alzheimer's disease [PDF]

Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face.
Chauhan, R, Chen, K-F, Crowther, DC, Kent, BA   +3 more
core   +1 more source

Confined spaces in space: Cerebral implications of chronic elevations of inspired carbon dioxide and implications for long‐duration space travel

Experimental Physiology, EarlyView.
Abstract Cerebrovascular regulation is critically dependent upon the arterial partial pressure of carbon dioxide (PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_{\mathrm{2}}}}}$), owing to its effect on cerebral blood flow, tissue PCO2${P_{{\mathrm{C}}{{\mathrm{O}}_{\mathrm{2}}}}}$, tissue proton concentration, cerebral metabolism and cognitive and neuronal ...
Jay M. J. R. Carr, Philip N. Ainslie, Trevor Day   +2 more
wiley   +1 more source

Poroelastic Modelling of CSF circulation via the incorporation of experimentally derived microscale water transport properties [PDF]

We outline how multicompartmental poroelasticity is applied to the study of dementia. We utilize a 3D version of our poroelastic code to investigate the effects within parenchymal tissue.
Chou, D, Guo, L, Jensen, V, Nagelhus, EA, Omholt, SW, Ottersen, OP, Pettersen, KH, Thoren, AE, Tully, BJ, Vardakis, IC, Ventikos, Y, Vindedal, GF   +11 more
core  

The diabetic brain and cognition [PDF]

The prevalence of both Alzheimer’s disease (AD) and vascular dementia (VaD) is increasing with the aging of the population. Studies from the last several years have shown that people with diabetes have an increased risk for dementia and cognitive ...
Ali Sameh S., Bajenaru Ovidiu, Choi Mun Seong, Chopp Michael, Dermanovic-Dobrota Vesna, Grünblatt Edna, Jellinger Kurt A., Kamal Mohammad Amjad, Kamal Warda, Korczyn Amos D., Riederer Peter, Vécsei László, Wojszel Zyta Beata, Yaman Hakan, Zhang Zheng G.   +14 more
core   +1 more source

Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline

Experimental Physiology, EarlyView.
Abstract Central arterial stiffening, particularly of the proximal aorta, is increasingly recognised as a pivotal contributor to cardiovascular disease, dementia, and mild cognitive impairment. Loss of Windkessel function amplifies pulsatile pressure, reduces diastolic perfusion and accelerates microvascular damage in the brain.
Jun Sugawara, Hirofumi Tanaka
wiley   +1 more source

Contributions of vascular ageing to late‐onset Alzheimer's disease

Experimental Physiology, EarlyView.
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson, Young Deanna Choi, Ashley E. Walker   +2 more
wiley   +1 more source