Results 121 to 130 of about 12,211 (230)

“Glymphatic” Neurodegeneration: Is Sleep the Missing Key?

Clinical and Translational Neuroscience
Robust evidence suggests that the glymphatic system plays a key role in preserving brain health. Indeed, its activity in maintaining homeostasis by clearing neurotoxic proteins such as beta-amyloid from the human brain is essential.
Luigi Ferini-Strambi, Maria Salsone
doaj   +1 more source

WWOX Mutation as a Rare Cause of Neonatal‐Infantile Parkinsonism Mimicking a Neurotransmitter Disorder: A Case Report

Journal of Paediatrics and Child Health, EarlyView.
Ozge Serce Pehlevan, Gizem Gider Yaman, Anıl Gok, Leman Tekin Orgun   +3 more
wiley   +1 more source

Glymphatic system function in patients with ischemic stroke evaluated by the DTI-ALPS method: a comprehensive review

Frontiers in Neurology
The glymphatic system is a glial-dependent waste clearance pathway in the central nervous system (CNS) of vertebrates that exploits the perivascular compartment between the vascular basement membrane (outermost wall of blood vessels) and astrocytic ...
Lichuan Zeng, Lichuan Zeng, Lichuan Zeng, Zihan Yin, Wei Li, Xiao Wang, Yaodan Zhang, Mingguo Xie, Ling Zhao   +8 more
doaj   +1 more source

Coupling between global brain blood oxygen level‐dependent activity and cerebrospinal fluid dynamics in young endurance athletes

Experimental Physiology, EarlyView.
Abstract Cerebrospinal fluid (CSF) contributes to brain waste clearance through its coupling with cerebral haemodynamics. Aerobic exercise promotes brain health, but its influence on brain waste clearance remains unclear. This study examined the coupling between CSF and cerebral haemodynamics in endurance athletes. Fifteen young male endurance athletes
Daisuke Hoshi, Marina Fukuie, Ryota Asahara, Tsubasa Tomoto, David C. Zhu, Rong Zhang, Keigo Ohyama‐Byun, Seiji Maeda, Jun Sugawara, Takashi Tarumi   +9 more
wiley   +1 more source

Brain strain: Blood flow and metabolism in environmental extremes

Experimental Physiology, EarlyView.
Abstract This narrative review compares and contrasts the most commonly encountered environmental stressors on human cerebrovascular functioning. From high altitude and space, extreme apnoea, heat and cold stress, the impact of these stressors on the regulation of cerebral blood flow (CBF) and oxygen metabolism (CMRO2${\mathrm{CM}}{{\mathrm{R}}_ ...
Dario Vrdoljak, Damian M. Bailey, Travis D. Gibbons, Philip N. Ainslie   +3 more
wiley   +1 more source

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, Volume 101, Issue 3, Page 1491-1510, June 2026.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source

Foreign body responses in central nervous system mimic natural wound responses and alter biomaterial functions [PDF]

, 2019
Biomaterials hold promise for diverse therapeutic applications in the central nervous system (CNS). Little is known about molecular factors that determine CNS foreign body responses (FBRs) in vivo , or about how such responses influence biomaterial ...
Ao, Yan, Deming, Timothy, Kim, Jae, O’Shea, Timothy, Sofroniew, Michael, Wollenberg, Alexander   +5 more
core   +1 more source

Relaxivity of Gadobutrol and Gadoteric Acid in Cerebrospinal Fluid at 3T

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3409-3415, June 2026.
ABSTRACT Purpose The aim was to estimate T1 relaxivity of gadobutrol and gadoteric acid in cerebrospinal fluid (CSF) at 3T, to support research on CSF‐flow and the glymphatic system in humans utilizing T1 mapping after intrathecal injection. Methods Using a phantom, relaxivity was estimated for gadobutrol and gadoteric acid in lumbar CSF and an ...
Sofia Behndig, Anders Garpebring, Daniel Dahlgren Lindström, Jan Malm, Anders Wåhlin, Anders Eklund   +5 more
wiley   +1 more source

A CFD and FEM Approach to a Multicompartmental Poroelastic Model for CSF Production and Circulation with Applicationsin Hydrocephalus Treatment and Cerebral Oedema [PDF]

, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014), Chou, D, Tully, BJ, Vardakis, JC, Ventikos, Y   +4 more
core  

Rapid Tissue‐CSF Water Exchange in the Human Brain Revealed by Magnetization Transfer Indirect Spin Labeling

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3270-3283, June 2026.
ABSTRACT Purpose To apply the Magnetization Transfer Indirect Spin Labeling (MISL) MRI technique for quantifying tissue‐CSF water exchange in the human brain, and to investigate its utility in (1) evaluating tissue‐CSF water exchange within perivascular spaces (PVS), and (2) characterizing altered water exchange dynamics in pathologic conditions ...
Yihan Wu, Kexin Wang, Licheng Ju, Anna Li, Qin Qin, Feng Xu, Doris D. M. Lin, Lawrence Kleinberg, Jiadi Xu   +8 more
wiley   +1 more source