Results 121 to 130 of about 18,116,541 (240)

An Investigation of Sleep Macro‐ and Microarchitecture by APOE Genotype

Annals of Neurology, Volume 100, Issue 5, Page 1012-1022, November 2026.
Objectives Apolipoprotein E ε4 (APOE ε4), a robust genetic risk factor for Alzheimer's disease (AD) is associated with functional connectivity deficits and amyloid pathology in brain regions involved in sleep regulation. Thus, alterations in sleep architecture may be one pathway through which ε4 contributes to Alzheimer's disease vulnerability. However,
Gawon Cho, Anne Chen, Eunyoung Choi, Orfeu M. Buxton, Daniel Kay, Adam Mecca, Brienne Miner   +6 more
wiley   +1 more source

Neurologic symptoms as a hallmark of glymphatic alteration in recovered patients with COVID-19

BMC Neurology
Background The glymphatic system is a glial-based perivascular network that facilitates the clearance of metabolic waste from the brain. Dysfunction of the glymphatic system, along with neurological symptoms such as cognitive deficits and olfactory ...
Minhoe Kim, Kyung Hoon Lee, Ji Su Ko, Myung Sub Kim, Kyu Sung Choi, Jiwon Seo, Minchul Kim   +6 more
doaj   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, Volume 100, Issue 5, Page 1055-1067, November 2026.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease

npj Parkinson's Disease
The characteristic asymmetric motor symptoms of Parkinson’s disease (PD) may be associated with asymmetric deposition of α-synuclein. The impaired glymphatic system may promote pathological deposition of α-synuclein, leading to disease progression.
Zihan Li, Xinxin Miao, Qiumei Zhang, Jun Shen, Yongfeng Jia, Shaoyun Ge, Peixian Ji, Jianwei Wang, Kezhong Zhang, Min Wang   +9 more
doaj   +1 more source

Brain Clearance of Contrast Agent in Intravenous DCE‐MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone

Magnetic Resonance in Medicine, Volume 96, Issue 5, Page 2309-2320, November 2026.
ABSTRACT Purpose To determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE‐MRI acquisitions and evaluate the contribution of blood–brain barrier (BBB) and non‐BBB clearance routes. Methods Uptake and extended Tofts models were fit to DCE‐MRI data from people with Parkinson's disease, post ...
Martin Kozár, Ioana‐Emilia Mosneag, Sarah Al‐Bachari, Igor Chernyavsky, Geoff J. M. Parker, Hervé Boutin, Laura M. Parkes, Ingo Schiessl, Ben R. Dickie   +8 more
wiley   +1 more source

The Ocular Glymphatic Clearance System

, 2019
Despite high metabolic activity, the retina and optic nerve head lack traditional lymphatic drainage. We here identified a novel ocular glymphatic clearance route for fluid and wastes via the proximal optic nerve.
L R Xavier, Anna, Lu, Chen, Jørgensen, Peter Kusk, Ertürk, Ali, Wang, Xiaowei, Eberhardt, Allison, Shi, Meng, Libby, Richard T., Yang, Yujia, Xu, Qiwu, Thrane, Alexander, Peng, Sisi, Nedergaard, Maiken, Lou, Nanhong, Foerstera, Benjamin   +14 more
core   +1 more source

Water and wisdom: Hydration as a defence against dementia

Experimental Physiology, EarlyView.
David C. Byfield, Damian M. Bailey
wiley   +1 more source

High‐Resolution IVIM MRI Characterizes Diffusion–Perfusion Properties of the Parasagittal Dura

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
Parasagittal dura demonstrates intermediate diffusion and elevated perfusion‐related IVIM metrics compared with brain parenchyma, reflecting its unique microfluidic environment at the CSF–dura interface. IVIM imaging of the parasagittal dura provides a rapid, noncontrast MRI approach to assess dural fluid transport and may offer a potential imaging ...
Yi‐Jui Liu, Chun‐Han Liao, Shin‐Lei Peng, Shao‐Chieh Lin, Chao‐Chun Lin, Chia‐Wei Lin, Chia‐Hong Hsieh, Chun‐Wen Chen, Hing‐Chiu Chang   +8 more
wiley   +1 more source

Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease

Translational Neurodegeneration
The glymphatic system serves as the brain’s clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer’s disease (AD).
Danrui Zhao, Junting Wang, Yirui Zhu, Hao Zhang, Chenkang Ni, Zhuowen Zhao, Jingyu Dai, Rongqiao He, Guangzhi Liu, Cheng Gan, Shouzi Zhang, Zhiqian Tong   +11 more
doaj   +1 more source

Wasteosomes accumulate in periventricular white matter hyperintensities and exhibit complex relationships with mixed pathology, sclerotic index, and perivascular space

Brain Pathology, Volume 36, Issue 6, November 2026.
In a mixed diagnostic cohort of pathologically diagnosed Alzheimer's disease, cerebrovascular disease, mixed pathology, and control tissue, we connected the histopathological wasteosome profile in periventricular (PV) brain sections to 7T FLAIR‐MRI confirmed PV white matter hyperintensities (WMHs), vascular stenosis and perivascular space size ...
Nikita Ollen‐Bittle, Isabella Boesgaard, Austyn Roseborough, Meaghan Frank, Qi Zhang, Stephen H. Pasternak, Robert Hammond, Shawn N. Whitehead   +7 more
wiley   +1 more source