Results 121 to 130 of about 17,183,881 (176)

Development and prospect of treating Alzheimer's disease using the glymphatic system

Journal of Alzheimer's Disease Reports
Alzheimer's disease (AD) is a common neurodegenerative disorder with progressive cognitive decline and typical amyloid-β (Aβ) and tau pathologies, whose pathogenesis remains unclear.
Jiajie Gu, Zekai Liu, Jiaxiang Gu
doaj   +1 more source

Routine Blood Indicators Combined With Sleep Questionnaires for the Identification of Cognitive Impairment in Parkinson's Disease: A Cross‐Sectional Study With a Leakage‐Free Nested Modeling Framework

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Background Cognitive impairment (CI) is a prevalent non‐motor complication of Parkinson's disease (PD), yet accessible and reliable screening aids remain limited. This cross‐sectional study aimed to quantify the strength of association and the cross‐sectional classification value of routine blood indicators combined with standardized sleep ...
Ziyi Wang, TszLeong Lam, Shuo Zhang, Chuanjin Song, Xiaoxue Pei, Junhong Zhong, Bin Li, Guilin Liu, Yingxue Cui, Shaosong Wang   +9 more
wiley   +1 more source

Diffusion–tensor MRI study of the relationship between glymphatic system asymmetry and onset lateralization in Parkinson’s disease

npj Parkinson's Disease
The characteristic asymmetric motor symptoms of Parkinson’s disease (PD) may be associated with asymmetric deposition of α-synuclein. The impaired glymphatic system may promote pathological deposition of α-synuclein, leading to disease progression.
Zihan Li, Xinxin Miao, Qiumei Zhang, Jun Shen, Yongfeng Jia, Shaoyun Ge, Peixian Ji, Jianwei Wang, Kezhong Zhang, Min Wang   +9 more
doaj   +1 more source

Additional Effects of 1‐Hz rTMS Combined With Tai Chi Chuan on Dual‐Task Performance Among Older Adults With Sleep Disorders and MCI: An fNIRS‐Based Randomized Controlled Trial

Brain and Behavior, Volume 16, Issue 9, September 2026.
1‐Hz rTMS enhances Tai Chi–induced improvements in dual‐task performance in older adults with sleep disorders and MCI, potentially via increased activation and functional connectivity within prefrontal and premotor regions. ABSTRACT Objective This study aimed to determine whether 1‐Hz repetitive transcranial magnetic stimulation (rTMS) combined with ...
Zhenxing Guo, Kaifeng Xu, Linxin Bai, Yuxuan Sun, Lin Zhang, Jiahui Gao, Lidian Chen, Zhizhen Liu   +7 more
wiley   +1 more source

Targeting the glymphatic system: Aβ accumulation and phototherapy strategies across different stages of Alzheimer’s disease

Translational Neurodegeneration
The glymphatic system serves as the brain’s clearance system. It deteriorates with age and is a significant contributor to the onset and progression of Alzheimer’s disease (AD).
Danrui Zhao, Junting Wang, Yirui Zhu, Hao Zhang, Chenkang Ni, Zhuowen Zhao, Jingyu Dai, Rongqiao He, Guangzhi Liu, Cheng Gan, Shouzi Zhang, Zhiqian Tong   +11 more
doaj   +1 more source

Choroid Plexus Microstructural Alterations Link Glymphatic Dysfunction and White Matter Degeneration in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This study investigates the role of choroid plexus (CP) microstructural alterations in Parkinson's disease (PD), using free‐water corrected diffusion tensor imaging (FW‐DTI). Elevated CP diffusion metrics were linked to glymphatic dysfunction, corpus callosum degeneration, and worsened motor and cognitive performance in PD patients.
Suyi Zhou, Zhiming Zhen, Cheng Lai, Peiyu Huang, Zhe Sun, Taotao Yang, Fengwei Yu, Wei Chen, Zhentao Zuo, Wei Chen   +9 more
wiley   +1 more source

Sleep Deprivation Induces Glial Dysfunction, Synaptic Loss, Metabolic Imbalance, and Cognitive Impairment in 12‐Month‐Old Mice: Protective Effects of D30

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Sleep deprivation induces neuroglial atrophy and dendritic spine loss, accompanied by metabolic disturbances involving 1‐methyladenosine, citric acid, L‐kynurenine, and berberine, indicating disrupted neuroenergetic and immunometabolic homeostasis. These alterations result in deficits in spatial recognition, fear conditioning, nesting, and Morris Water
Xueyan Liu, Huiling Lin, Jian Zhong, Xili Chen, Zonglin Wang, Meng Shi, Hang Shi, Hui Zhang, Ping Chen, Zu‐Cheng Ye   +9 more
wiley   +1 more source

Glymphatic activity is linked to the synaptic vesicle cycle pathway in frontotemporal dementia: A metabolomics study

Neurobiology of Disease
Background: Emerging evidence implicating glymphatic dysfunction contributes to the pathogenesis of frontotemporal dementia (FTD). However, the pathway correlated to glymphatic function in FTD remains poorly understood.
Min Chu, Ailing Yue, Haitian Nan, Hong Ye, Miao Qu, Liyong Wu   +5 more
doaj   +1 more source

A Pilot Study Evaluating the Effect of Artesunate on Glymphatic‐Related Fluid Transport in Parkinson's Disease Mouse Models In Vivo and Ex Vivo

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Artesunate (ART) treatment was associated with enhanced glymphatic CSF‐ISF exchange in both wild‐type (WT) and A53T mouse models of Parkinson's disease, with regional differences observed by dynamic MRI. In A53T mice, ART was associated with restoration of AQP4 polarization and reduced α‐syn levels in the SN.
Wan‐ting Han, Wen‐hui Lu, Hui Xu, Guang‐hui Xie, Yan Cao, Xin‐ying Wu, Fan Qiu, Tong Fu   +7 more
wiley   +1 more source

Repetitive Transcranial Magnetic Stimulation in Alzheimer's Disease Cognitive Impairment: A Narrative Review of Clinical Trials

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Alzheimer's disease (AD), primarily characterized by cognitive impairment, places an immense burden on patients and caregivers. Non‐invasive neuromodulation with repetitive transcranial magnetic stimulation has been proposed to improve cognition in mild to moderate AD. This narrative review aimed to summarize clinical trial
Tejiri Napoleon, Deborah Akinrinde, Victor Oluwafemi Femi‐Lawal, Glory Olalekan Adebajo, Hermann Yokolo, Faith Uzoamaka Okei, Gbenga Alabi, Ojo Israel Ifeoluwa, Sodiq Olatunbosun Lawal, Samuel Oluwatimilehin Abati, Chioma Nnedinma Duru, Olawoyin Oluwatosin, Ishaq Oyeshina Sanusi, Adeyemi Owoseni Solomon, Angel Clement, Tahir Bello, Emmanuela Ojoagefu Egwu, Emmanuel Kodizuru Chukwuemeka   +17 more
wiley   +1 more source