Results 91 to 100 of about 12,211 (230)

Central and peripheral circadian clocks and their role in Alzheimer's disease [PDF]

, 2017
Molecular and cellular oscillations constitute an internal clock that tracks the time of day and permits organisms to optimize their behaviour and metabolism to suit the daily demands they face.
Chauhan, R, Chen, K-F, Crowther, DC, Kent, BA   +3 more
core   +2 more sources

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Interplay between the glymphatic system and neurotoxic proteins in Parkinson's disease and related disorders: current knowledge and future directions

Neural Regeneration Research
Parkinson's disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins, including α-synuclein, amyloid-β, and tau, in addition to the impaired elimination of these neurotoxic ...
Yumei Yue, Xiaodan Zhang, Wen Lv, Hsin-Yi Lai, Ting Shen   +4 more
doaj   +1 more source

Exploring the association between Alzheimer’s disease, oral health, microbial endocrinology and nutrition [PDF]

, 2017
Longitudinal monitoring of patients suggests a causal link between chronic periodontitis and the development of Alzheimer’s disease (AD). However, the explanation of how periodontitis can lead to dementia remains unclear.
Ahmed, Al-Qutub, Alice Harding, Bakarcic, Barr, Bawadi, Bazzano, Bergström, Bhattacharjee, Bonfim, Borrell, Brandscheid, Bravo, Brayne, Bredesen, Bredesen, Bredesen, Brown, Calder, Cannizzo, Carrasco-Benso, Carter, Cekici, Chen, Chen, Clark, Clarke, Courchesne-Loyer, Craft, Crane, Cunnane, Cunnane, Cunnane, Cunnane, Darveau, Daulatzai, Dehghan, Diaz Heijtz, Ding, Dodington, Dunn, Ebrahim, Emery, Engelhart, Estruch, Eussen, Evers, Foster, Galland, Genco, Grant, Greiner, Grossi, Górska, Hamasaki, Hara, Harcombe, Harding, Heo, Herath, Hession, Holmes, Hsu, Ide, Iliff, Jayaram, Joshipura, Kamer, Kamer, Kamma, Kaushik, Kerti, Kim, Kim, Kondo, Krasse, Krueger, Kullmann, Köbe, Larsen, LeRoith, Libby, Lin, Loesche, Loos, Luo, Lyte, Lyte, Marden, Martínez-Lapiscina, McDade, Miklossy, Miklossy, Miranda, Morris, Morris, Newport, Nonaka, Olsen, Olsen, O’Brien, Paganini-Hill, Park, Peedikayil, Persson, Peuhkuri, Pigeon, Pistollato, Poole, Poole, Poulose, Quinn, Ravnskov, Reger, Reid, Reife, Remington, Riccia, Rincon, Riviere, Rosenberg, Russ, Salas-Salvadó, Sarita J. Robinson, Schmidt, Schwingshackl, Schätzel, Selhub, Shai, Ship, Sim K. Singhrao, Singh, Singh, Singhrao, Slawik, Sparks Stein, Sprecher, Stein, StJohn Crean, Sudo, Taafe, Taguchi, Takahashi, Takayama, Tawse-Smith, Tezal, Thevenet, Toffanello, Toffanello, Ulrike Gonder, Varela-López, Volek, Waddington, Wang, Yao, Yesavage, Yurko-Mauro, Zambon, Zhan, Zhang, Zhao   +160 more
core   +2 more sources

Stress and the glymphatic system

, 2020
Psychoneuroendocrinoimmunology (PNEI) is an integrative discipline studying the processes by which mental events modulate immune functions and how the immune system in turn can alter brain function. The central nervous system (CNS) is the only system in the body lacking its own anatomically defined lymphatic vessels.
Mariya Ivanovska, Meral Naimova, Marianna Murdjeva   +2 more
openaire   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Dissociation of Cerebral Blood Flow and Femoral Artery Blood Pressure Pulsatility After Cardiac Arrest and Resuscitation in a Rodent Model: Implications for Neurological Recovery. [PDF]

, 2020
Background Impaired neurological function affects 85% to 90% of cardiac arrest (CA) survivors. Pulsatile blood flow may play an important role in neurological recovery after CA.
Akbari, Yama, Bazrafkan, Afsheen, Choi, Bernard, Crouzet, Christian, Lee, Donald, Tromberg, Bruce J, Wilson, Robert H   +6 more
core   +1 more source

The diabetic brain and cognition [PDF]

, 2017
The prevalence of both Alzheimer’s disease (AD) and vascular dementia (VaD) is increasing with the aging of the population. Studies from the last several years have shown that people with diabetes have an increased risk for dementia and cognitive ...
Ali Sameh S., Bajenaru Ovidiu, Choi Mun Seong, Chopp Michael, Dermanovic-Dobrota Vesna, Grünblatt Edna, Jellinger Kurt A., Kamal Mohammad Amjad, Kamal Warda, Korczyn Amos D., Riederer Peter, Vécsei László, Wojszel Zyta Beata, Yaman Hakan, Zhang Zheng G.   +14 more
core   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Glymphatic System Pathology and Neuroinflammation as Two Risk Factors of Neurodegeneration

Cells
The key to the effective treatment of neurodegenerative disorders is a thorough understanding of their pathomechanism. Neurodegeneration and neuroinflammation are mutually propelling brain processes.
Stanisław Szlufik, Kamila Kopeć, Stanisław Szleszkowski, Dariusz Koziorowski   +3 more
doaj   +1 more source