Results 91 to 100 of about 18,116,541 (240)

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

Reply to: The Physical Foundation of CSF‐IVIM

Magnetic Resonance in Medicine, EarlyView.
Yoshitaka Bito, Tomohiro Otani, Shigeki Yamada, Yoshiyuki Watanabe, Shigeo Wada   +4 more
wiley   +1 more source

Distribution and target engagement of peripherally administered fremanezumab in the cerebrospinal fluid of healthy volunteers

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Our objective was to describe the distribution of fremanezumab to the cerebrospinal fluid (CSF) in healthy volunteers, and investigate its engagement and stabilization of its target, calcitonin gene‐related peptide (CGRP). Fremanezumab is a CGRP‐targeting monoclonal antibody approved for migraine prevention.
Jacki Rorabaugh, Edward Hellriegel, Juline Bryson, Ryan Tiver, Hang Zeng, Xiaofeng Lu, Steve Barash, Giulia Ghibellini, Olga Szilagyi, Ignacio Echenique, Andrew H. Ahn, Peter J. Goadsby, Laura Rabinovich‐Guilatt   +12 more
wiley   +1 more source

Elevated Blood Pressure Is Causally Associated With Larger Subcortical Gray Matter Structure Through Perivascular Clearance Routes

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Background This study aimed to investigate the association between elevated blood pressure (BP) and subcortical gray matter structures, and to elucidate the causality and underlying mechanisms. Methods This study enrolled 1012 participants from a multicenter, population‐based cohort study in China.
Jing Sun, Jing Li, Xiaoshuai Li, Xinyu Zhao, Pengfei Zhao, Zhenghan Yang, Shuohua Chen, Shouling Wu, Ying Hui, Zhenchang Wang, Han Lv   +10 more
wiley   +1 more source

Glymphatic system and mild traumatic brain injury: a mini review

Frontiers in Neuroscience
Since the discovery of the glymphatic system in 2012, research on this brain-wide fluid exchange pathway has focused on understanding its role in different neurological diseases.
Pihla Miettinen, Begüm Utz, Ivette Bañuelos-Cabrera, Eugene Golanov, Ziv Lenzner, Leonardo Lara-Valderrábano, Lasse Välimaa, Adrian Harel   +7 more
doaj   +1 more source

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Glucocorticoid signalling coordinating circadian rhythms between the glymphatic system and sleep contributes to brain health [PDF]

Exploration of Endocrine and Metabolic Diseases
Circadian rhythms are present in almost every cell of the body and play important roles in various physiological processes. The central circadian clock in the suprachiasmatic nucleus (SCN) is synchronized to the environmental light-dark cycle and ensures
Laura C. A. van der Zwet, Stephan Michel, Tom Deboer   +2 more
doaj   +1 more source

Decrease of excessive daytime sleepiness after shunt treatment for normal pressure hydrocephalus

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleepiness and apathy are often reported in patients with normal pressure hydrocephalus. However, research on outcomes after shunt surgery has mainly focused on the classical triad symptoms, that is, gait, cognition, and bladder dysfunction. This study aimed to describe the effects of shunt treatment on excessive daytime sleepiness and whether ...
Simon Lidén, Anna Lindam, Dan Farahmand, Anne‐Marie Landtblom, Katarina Laurell   +4 more
wiley   +1 more source

Changes in Nighttime Sleep Duration and Their Association With Cognitive Decline and Dementia Risk

Journal of Sleep Research, EarlyView.
ABSTRACT This study investigates changes in nighttime sleep duration in relation to cognitive decline and risk of incident dementia. A total of 3057 participants from the Swedish population study ‘Good Aging in Skåne’ (Mage = 68.4) with normal baseline sleep duration (6–8 h) were followed up to 20 years (Myears = 8.39). Self‐reported change was defined
Marieclaire Overton, Sölve Elmståhl, Rani Basna   +2 more
wiley   +1 more source

40 Hz light flickering facilitates the glymphatic flow via adenosine signaling in mice

Cell Discovery
The glymphatic-lymphatic system is increasingly recognized as fundamental for the homeostasis of the brain milieu since it defines cerebral spinal fluid flow in the brain parenchyma and eliminates metabolic waste.
Xiaoting Sun, Liliana Dias, Chenlei Peng, Ziyi Zhang, Haoting Ge, Zejun Wang, Jiayi Jin, Manli Jia, Tao Xu, Wei Guo, Wu Zheng, Yan He, Youru Wu, Xiaohong Cai, Paula Agostinho, Jia Qu, Rodrigo A. Cunha, Xuzhao Zhou, Ruiliang Bai, Jiang-fan Chen   +19 more
doaj   +1 more source