The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease [PDF]
Biomolecules, 2022 There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be
Yu Tian, Yilong Wang, Yiyi Chen
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Ultrasmall inorganic nanoparticles repair damaged meningeal lymphatic vessels to boost Parkinson’s disease therapy [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaSignificance Meningeal lymphatic vessels (MLVs) play a crucial role in maintaining the health of the central nervous system (CNS). Targeted repair of the damaged MLV has emerged as an innovative and promising therapeutic strategy for treating these ...
, Yaobao Han, Zhilin Jiang
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Role of meningeal lymphatic vessels in brain homeostasis [PDF]
Frontiers in ImmunologyMeningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Meng-Ying Zhao +8 more
doaj +3 more sources
The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders [PDF]
Journal of Cerebral Blood Flow and Metabolism, 2022 The recent discovery of the meningeal lymphatic vessels (mLVs) and glymphatic pathways has challenged the long-lasting dogma that the central nervous system (CNS) lacks a lymphatic system and therefore does not interact with peripheral immunity.
Xin Tang, Liangxue Zhou, Gaowei Li
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Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels [PDF]
Frontiers in Immunology, 2020 Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint +9 more
doaj +3 more sources
Development and plasticity of meningeal lymphatic vessels [PDF]
Journal of Experimental Medicine, 2017 The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance.
Thomas Mathivet +2 more
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Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels [PDF]
Acta Neuropathologica Communications, 2020 Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now.
Xuanhui Liu +15 more
doaj +3 more sources
Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease. [PDF]
J Alzheimers Dis, 2023 Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the meninges, are the key drainage route responsible for the clearance of molecules, immune cells, and cellular debris from the cerebrospinal fluid and interstitial fluid into
Guo X +5 more
europepmc +2 more sources
Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson's Disease. [PDF]
Research (Wash D C), 2023 Targeted therapy of Parkinson’s disease is an important challenge because of the blood–brain barrier limitation. Here, we propose a natural killer cell membrane biomimetic nanocomplex (named BLIPO-CUR) delivered via the meningeal lymphatic vessel (MLV ...
Liu J +7 more
europepmc +2 more sources
Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice. [PDF]
J Clin Invest, 2023 Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance.
Matrongolo MJ +9 more
europepmc +2 more sources