Results 1 to 10 of about 373,387 (179)

The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease [PDF]

Biomolecules, 2022
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be
Yu Tian, Mengxi Zhao, Yiyi Chen, Mo Yang, Yilong Wang   +4 more
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Role of meningeal lymphatic vessels in brain homeostasis [PDF]

Frontiers in Immunology
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Meng-Ying Zhao, Chao-Yuan Ye, Yuan-Cheng Liu, Xiao-Ming Wang, Jun-Cai Fu, Xin-Yuan Liu, Rui Zhu, Yi-Zhao Li, Qing Tian   +8 more
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Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels [PDF]

Frontiers in Immunology, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint, László Bálint, Zsombor Ocskay, Zsombor Ocskay, Bálint András Deák, Bálint András Deák, Petra Aradi, Petra Aradi, Zoltán Jakus, Zoltán Jakus   +9 more
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Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
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Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels [PDF]

Acta Neuropathologica Communications, 2020
Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now.
Xuanhui Liu, Chuang Gao, Jiangyuan Yuan, Tangtang Xiang, Zhitao Gong, Hongliang Luo, Weiwei Jiang, Yiming Song, Jinhao Huang, Wei Quan, Dong Wang, Ye Tian, Xintong Ge, Ping Lei, Jianning Zhang, Rongcai Jiang   +15 more
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Long-term exercise enhances meningeal lymphatic vessel plasticity and drainage in a mouse model of Alzheimer's disease

Translational Neurodegeneration
Background Meningeal lymphatic drainage is crucial for the clearance of amyloid β (Aβ), supporting the maintenance of brain homeostasis. This makes it a promising therapeutic target for Alzheimer's disease (AD).
Yan Chen, Jiachen Cai, Yuzhu She, Xiaoxin He, Hu Feng, Xuewei Li, Yiran Wei, Yi Fan, Wen-e Zhao, Mengmei Yin, Linjuan Yuan, Yuxi Jin, Fengfei Ding, Chengyu Sheng, Junying Gao, Qian Li, Ming Xiao   +16 more
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Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases [PDF]

Translational Neurodegeneration
The brain was long been regarded as an immune-privileged organ with a lack of lymphatic drainage, partly because of the absence of parenchymal lymphatic vessels.
Shixin Ding, Jiguang Yang, Ze Wang, Ruiliang Bai, Kuiying Yin, Lei Jin, Maximilian Kueckelhaus, Sven G. Meuth, Ming Xiao, Gang Hu   +9 more
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Meningeal lymphatic dysfunction in Alzheimer’s disease: molecular mechanisms, clinical implications, and future perspectives [PDF]

Molecular Neurodegeneration
The meningeal lymphatic system has recently emerged as a critical regulator of brain homeostasis, facilitating cerebrospinal fluid drainage, metabolic waste clearance, and immune cell trafficking.
Lian Liu, Jiang-Hui Li, Yu-Di Bai, Yan-Jiang Wang, Xian-Le Bu   +4 more
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Lymphatic-Immune Microenvironment Engineering via Rapamycin-Eluting Nanofibers for Meningeal Repair and Neuroprotection in Traumatic Brain Injury Rats [PDF]

Research
While current dural repair patches achieve mechanical sealing to prevent cerebrospinal fluid leakage, they fail to address the critical pathological cascades of traumatic brain injury, including structural disruption of meningeal lymphatic vessels and ...
Liyuan Zhong, Yu You Huang, Jiaxuan Xie, Xiaofei Han, Yumin Luo, Hanqi Liu, Chunhao Yu, Yi Ming Huang, Yufeng Zheng, Hao Sun, Qing Liu, Zhi Liu, Di Wu, Xunming Ji, Miaowen Jiang, Ming Li   +15 more
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Impaired meningeal lymphatic drainage in Listeria monocytogenes infection

Frontiers in Immunology
Previous studies have demonstrated an association between lymphatic vessels and diseases caused by bacterial infections. Listeria monocytogenes (LM) bacterial infection can affect multiple organs, including the intestine, brain, liver and spleen, which ...
Jian Feng, Yuanzhen Ren, Xilin Wang, Xilin Wang, Xiaojing Li, Xingguo Zhu, Baokai Zhang, Baokai Zhang, Qi Zhao, Xiaochen Sun, Xinxin Tian, Hongyang Liu, Fan Dong, Xiu-Li Li, Linlin Qi, Bin Wei, Bin Wei   +16 more
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