Results 1 to 10 of about 36,804 (221)

Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

Frontiers in Physiology, 2019
The contribution of cranial dura mater vascular networks, as means for maintaining brain fluid movement and balance, and as the source of significant initiators and/or contributors to neurological disorders, has been overlooked. These networks consist of
Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Virginia H. Huxley, Virginia H. Huxley, Virginia H. Huxley, Leike Xie, Filiz Bunyak, Kannappan Palaniappan, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky   +13 more
doaj   +1 more source

Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation [PDF]

, 2016
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and stromal cells that provide ectopic hubs for acquired immune responses.
Christopher D. Buckley, David H. Gardner, Francesca Barone, Nathalie Steinthal, Saba Nayar, Sanjiv A. Luther   +5 more
core   +3 more sources

Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: prospects and challenges

Frontiers in Cell and Developmental Biology
The brain has traditionally been considered an “immune-privileged” organ lacking a lymphatic system. However, recent studies have challenged this view by identifying the presence of the glymphatic system and meningeal lymphatic vessels (MLVs).
Rui Zhang, Jiuhong Li, Xueying Li, Si Zhang   +3 more
doaj   +1 more source

Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery [PDF]

, 2018
The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D.
A Anisimov, A Louveau, AK Alitalo, G Paxinos, H Nurmi, K Alitalo, P Colella, S Antila, S Fang, S Karaman, TV Petrova   +10 more
core   +1 more source

Spatiotemporal dynamic changes of meningeal microenvironment influence meningeal lymphatic function following subarachnoid hemorrhage: from inflammatory response to tissue remodeling

Journal of Neuroinflammation
Background Meningeal lymphatic vessels (mLVs) play a critical role in clearing erythrocytes from the subarachnoid space and immune cells from the brain parenchyma following subarachnoid hemorrhage (SAH). However, the drainage function of mLVs is impaired
Bingrui Zhu, Changming Liu, Ming Luo, Jiarui Chen, Sixuan Tian, Tiantong Zhan, Yibo Liu, Haocheng Zhang, Zhen Wang, Jianmin Zhang, Yuanjian Fang, Sheng Chen, Xiaoyu Wang   +12 more
doaj   +1 more source

Magnetic Resonance Imaging and Histopathological Visualization of Human Dural Lymphatic Vessels

Bio-Protocol, 2018
In this protocol, we describe a method to visualize and map dural lymphatic vessels in-vivo using magnetic resonance imaging (MRI) and ex-vivo using histopathological techniques.
Seung-Kwon Ha, Govind Nair, Martina Absinta, Nicholas Luciano, Daniel Reich   +4 more
doaj   +1 more source

Incorporating meningeal immunity into vaccine development

Nature Communications
Meningeal immunity, a less-studied aspect of neuroimmune interactions, has recently come under the spotlight owing to the characterization of meningeal lymphatic vessels draining of the central nervous system (CNS).
Manisha Menon, Colin N. Haile, David J. Dowling   +2 more
doaj   +1 more source

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury [PDF]

, 2018
The migration of polymorphonuclear granulocytes (PMN) into the brain parenchyma and release of their abundant proteases are considered the main causes of neuronal cell death and reperfusion injury following ischemia.
Beschorner, Rudi, Cheng, Yu-Jung, Dirnagl, Ulrich, Endres, Matthias, Engelhardt, Britta, Enzmann, Gaby, Ghavampour, Sharang, Gorina, Roser, Hannocks, Melanie-Jane, Harter, Patrick, Mittelbronn, Michel, Mysiorek, Caroline, Prinz, Marco, Prinz, Vincent, Sorokin, Lydia   +14 more
core  

Impairment of the intracranial lymphatic system in Parkinson's disease: a combined study of the meningeal lymphatics vessels and glymphatic system based on noninvasive neuroimaging [PDF]

Mingxian Huang, Pan Zhang, Zhen Chen, Xiaoyan Wang, Hui Li, Shangwen Xu, Lan Li, Wenxi Zheng, Hui Xiao   +8 more
openalex   +3 more sources

Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice

Nature Communications
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Miao Wang, Congcong Yan, Xi Li, Tianhao Yang, Shengnan Wu, Qian Liu, Qingming Luo, Feifan Zhou   +7 more
doaj   +1 more source