eLife, 2017 Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta +10 more
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Meningeal lymphatics as a therapeutic target for neurodegenerative disorders [PDF]
Translational NeurodegenerationAdvancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune ...
Yijia Feng +6 more
doaj +2 more sources
Meningeal lymphatic dysfunction mediates postoperative sleep deprivation-induced cognitive decline via impaired neuroinflammatory clearance [PDF]
Journal of NeuroinflammationPostoperative sleep deprivation (PSD) exacerbates perioperative neurocognitive disorders (PND) through unresolved neuroinflammation, yet the underlying mechanisms remain elusive.
Binkang Huang +18 more
doaj +2 more sources
Magnetic Resonance Imaging and Histopathological Visualization of Human Dural Lymphatic Vessels
Bio-Protocol, 2018 In this protocol, we describe a method to visualize and map dural lymphatic vessels in-vivo using magnetic resonance imaging (MRI) and ex-vivo using histopathological techniques.
Seung-Kwon Ha +4 more
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Gene expression in meningeal lymphatic endothelial cells following traumatic brain injury in mice.
PLoS ONE, 2022 Meningeal lymphatic vessels transport both the cerebrospinal fluid and interstitial fluid to the deep cervical lymph nodes. Traumatic brain injury (TBI) is accompanied by meningeal injury.
Ryo Shimada +2 more
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Cells with Many Talents: Lymphatic Endothelial Cells in the Brain Meninges
Cells, 2021 The lymphatic system serves key functions in maintaining fluid homeostasis, the uptake of dietary fats in the small intestine, and the trafficking of immune cells. Almost all vascularized peripheral tissues and organs contain lymphatic vessels. The brain
Irina Suárez, Stefan Schulte-Merker
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Fluids and Barriers of the CNS, 2023 Background Despite greatly renewed interest concerning meningeal lymphatic function over recent years, the lymphatic structures of human dura mater have been less characterized. The available information derives exclusively from autopsy specimens.
César Luis Vera Quesada +3 more
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Research Progress on Intracranial Lymphatic Circulation and Its Involvement in Disorders
Frontiers in Neurology, 2022 The lymphatic system is an important part of the circulatory system, as an auxiliary system of the vein, which has the functions of immune defense, maintaining the stability of the internal environment, and regulating the pressure of the tissue.
Fan Chen, Xuan Xie, Liang Wang
doaj +1 more source
Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics [PDF]
Journal of Innovative Optical Health Sciences, 2020 Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain barrier (BBB) permeability open novel strategies for drug-brain delivery ...
A. Abdurashitov +2 more
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Meningeal lymphatics and their role in CNS disorder treatment: moving past misconceptions
Frontiers in Neuroscience, 2023 The central nervous system (CNS) was previously thought to lack lymphatics and shielded from the free diffusion of molecular and cellular components by the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCB).
Alexandra Melloni +8 more
doaj +1 more source