Results 21 to 30 of about 34,570 (162)

Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage. [PDF]

open access: yesJ Neuroinflammation
Subarachnoid hemorrhage (SAH) is a severe cerebrovascular disorder primarily caused by the rupture of aneurysm, which results in a high mortality rate and consequently imposes a significant burden on society.
Gao D   +8 more
europepmc   +2 more sources

Metal-Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels-Bridged Intracranial-Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression. [PDF]

open access: yesAdv Sci (Weinh)
Glioblastoma (GBM) presents significant challenges in treatment due to the presence of the blood‐brain barrier (BBB) and immunosuppressive tumor microenvironment (TME).
Zhang C   +11 more
europepmc   +2 more sources

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

open access: yesThe Journal of Clinical Investigation, 2023
Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance.
Matt J. Matrongolo   +9 more
doaj   +2 more sources

Serotype-specific tropism of adeno-associated viruses in dorsal meningeal lymphatic vessels via intra-cisterna magna delivery. [PDF]

open access: yesFront Immunol
Background Meningeal lymphatic vessels (mLVs) in the brain acts as the regulator that eliminates harmful macromolecules in post-cerebrospinal fluid (CSF) and facilitates immune cell migration to cervical lymph nodes. However, it still poses challenges on
Ren B   +6 more
europepmc   +2 more sources

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

open access: yeseLife, 2017
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta   +10 more
doaj   +3 more sources

Targeting Meningeal Lymphatic Vessels to Advance Stroke Therapy.

open access: yesaging and disease
Meningeal lymphatic vessels (mLVs) have recently emerged as pivotal regulators of central nervous system homeostasis, orchestrating cerebrospinal fluid (CSF) drainage, metabolic waste clearance, and neuroimmune surveillance at the brain and meningeal ...
Yang Liu   +9 more
semanticscholar   +2 more sources

Impaired meningeal lymphatic drainage in Listeria monocytogenes infection

open access: yesFrontiers in Immunology
Previous studies have demonstrated an association between lymphatic vessels and diseases caused by bacterial infections. Listeria monocytogenes (LM) bacterial infection can affect multiple organs, including the intestine, brain, liver and spleen, which ...
Jian Feng   +16 more
exaly   +3 more sources

Meningeal lymphatic drainage: novel insights into central nervous system disease

open access: yesSignal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang   +6 more
doaj   +2 more sources

The emerging role of the meningeal lymphatic and glymphatic systems in migraine pathophysiology: a systematic review [PDF]

open access: yesThe Journal of Headache and Pain
Background/objective Migraine is a common, debilitating neurological disorder of unclear pathophysiology. Recent evidence has implicated impaired meningeal lymphatic function and its interaction with the glymphatic system in the development of ...
Kimia Bagheri   +7 more
doaj   +2 more sources

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