Results 21 to 30 of about 373,387 (179)

Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin [PDF]

Scientific Reports
In humans and mice, the glymphatic system, critical for central nervous system (CNS) health, relies on cardiorespiratory coupling, but has not yet been investigated in a diving mammal that routinely experiences apnea, bradycardia, and peripheral ...
Tiffany F. Keenan, Olivia N. Jackson, Nathan P. Nelson-Maney, Sentiel A. Rommel, William A. McLellan, D. Ann Pabst, Alexander M. Costidis, Kathleen M. Caron, Dawn N. Kernagis, David S. Rotstein, Molly Braun, Michael S. Tift   +11 more
doaj   +3 more sources

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease. [PDF]

J Alzheimers Dis, 2023
Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the meninges, are the key drainage route responsible for the clearance of molecules, immune cells, and cellular debris from the cerebrospinal fluid and interstitial fluid into deep cervical lymph nodes.
Guo X, Zhang G, Peng Q, Huang L, Zhang Z, Zhang Z.   +5 more
europepmc   +3 more sources

Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

Translational Neurodegeneration, 2019
Background Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson’s disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD.
Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Renhong Du, Ming Xiao, Gang Hu   +7 more
doaj   +2 more sources

Overview of the meningeal lymphatic vessels in aging and central nervous system disorders. [PDF]

Cell Biosci, 2022
AbstractIn the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even cerebrovascular disease. These findings reveal a new perspective on aging and CNS disorders and provide a
Jiang H, Wei H, Zhou Y, Xiao X, Zhou C, Ji X.   +5 more
europepmc   +4 more sources

Meningeal lymphatic vessels regulate brain tumor drainage and immunity. [PDF]

Cell Res, 2020
AbstractRecent studies have shown that meningeal lymphatic vessels (MLVs), which are located both dorsally and basally beneath the skull, provide a route for draining macromolecules and trafficking immune cells from the central nervous system (CNS) into cervical lymph nodes (CLNs), and thus represent a potential therapeutic target for treating ...
Hu X, Deng Q, Ma L, Li Q, Chen Y, Liao Y, Zhou F, Zhang C, Shao L, Feng J, He T, Ning W, Kong Y, Huo Y, He A, Liu B, Zhang J, Adams R, He Y, Tang F, Bian X, Luo J.   +21 more
europepmc   +4 more sources

Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review [PDF]

Frontiers in Immunology
Glymphatic transport, meningeal lymphatic drainage, and meningeal immunity have been implicated in metabolic waste clearance, cerebral edema formation, and the regulation of neuroinflammation after stroke.
Yuyin Han, Yuyin Han, Boran Dong, Shuhao Mei, Shuhao Mei, Hailian Yi, Hailian Yi, Meiting Li, Meiting Li, Mengyan Sun, Mengyan Sun, Wenzhen Zhuo, Wenzhen Zhuo, Han Wang, Han Wang, Yong Liu, Xiaoyang Gong   +16 more
doaj   +2 more sources

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice. [PDF]

J Clin Invest, 2023
Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance.
Matrongolo MJ, Ang PS, Wu J, Jain A, Thackray JK, Reddy A, Sung CC, Barbet G, Hong YK, Tischfield MA.   +9 more
europepmc   +2 more sources

Meningeal Lymphatic Vessels: A Drain of the Brain Involved in Neurodegeneration? [PDF]

Neurosci Bull, 2020
Cheng Y, Wang YJ, Wang YJ.
europepmc   +4 more sources

Incorporating meningeal immunity into vaccine development

Nature Communications
Meningeal immunity, a less-studied aspect of neuroimmune interactions, has recently come under the spotlight owing to the characterization of meningeal lymphatic vessels draining of the central nervous system (CNS).
Manisha Menon, Colin N. Haile, David J. Dowling   +2 more
doaj   +2 more sources

The meningeal lymphatic vessel–peripheral immune axis: a novel therapeutic target in neurodegenerative diseases [PDF]

Journal of Neuroinflammation
Meningeal lymphatic vessels serve as a direct anatomical conduit connecting the central nervous system and the peripheral immune system, fundamentally challenging the traditional view of the brain as an "immune-privileged" organ.
Zhidong He, Jing Sun
doaj   +2 more sources