Results 21 to 30 of about 6,220 (169)

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
doaj   +2 more sources

Morphology of the glymphatic and meningeal lymphatic structures of the bottlenose dolphin

Scientific Reports
In humans and mice, the glymphatic system, critical for central nervous system (CNS) health, relies on cardiorespiratory coupling, but has not yet been investigated in a diving mammal that routinely experiences apnea, bradycardia, and peripheral ...
Tiffany F. Keenan, Olivia N. Jackson, Nathan P. Nelson-Maney, Sentiel A. Rommel, William A. McLellan, D. Ann Pabst, Alexander M. Costidis, Kathleen M. Caron, Dawn N. Kernagis, David S. Rotstein, Molly Braun, Michael S. Tift   +11 more
doaj   +3 more sources

Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress

Research, 2023
Studies have demonstrated that a functional network of meningeal lymphatic vessels exists in the brain. However, it is unknown whether lymphatic vessels could also extend deep into the brain parenchyma and whether the vessels could be regulated by ...
Junzhuang Chang, Bingqing Guo, Yan Gao, Wei Li, Xiaoyu Tong, Yi Feng, Nashat Abumaria   +6 more
doaj   +2 more sources

Impaired Meningeal Lymphatic Vessel Development Worsens Stroke Outcome [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2020
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3 ...
Hominick, Devon, Khurana, Noor, Yanev, Pavel, Berndt, Marcus, Dellinger, Michael T., Zuurbier, Kielen R., Plautz, Erik J., Poinsatte, Katherine, Stowe, Ann M.   +8 more
core   +3 more sources

Meningeal Lymphatic and Glymphatic Structures in a Pelagic Delphinid (Delphinus delphis)

Animals
The glymphatic system, an analog of the peripheral lymphatic system in the brain, and the meningeal lymphatic system are critical to central nervous system health.
Olivia N. Jackson, Tiffany F. Keenan, Nathan P. Nelson-Maney, Sentiel A. Rommel, William A. McLellan, D. Ann Pabst, Alexander M. Costidis, Kathleen M. Caron, Dawn N. Kernagis, David S. Rotstein, Victoria G. Thayer, Craig A. Harms, Marina A. Piscitelli-Doshkov, Paul Doshkov, Lorian E. Schweikert, Kara E. Yopak, Molly Braun, Michael S. Tift   +17 more
doaj   +2 more sources

Application of optical coherence tomography for in vivo monitoring of the meningeal lymphatic vessels during opening of blood-brain barrier: mechanisms of brain clearing. [PDF]

J Biomed Opt, 2017
The meningeal lymphatic vessels were discovered 2 years ago as the drainage system involved in the mechanisms underlying the clearance of waste products from the brain.
Semyachkina-Glushkovskaya O, Abdurashitov A, Dubrovsky A, Bragin D, Bragina O, Shushunova N, Maslyakova G, Navolokin N, Bucharskaya A, Tuchin V, Kurths J, Shirokov A.   +11 more
europepmc   +2 more sources

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury [PDF]

Brain, Behavior, & Immunity - Health, 2022
Understanding the pathological mechanisms unfolding after chronic traumatic brain injury (TBI) could reveal new therapeutic entry points. During the post-TBI sequel, the involvement of cerebrospinal fluid drainage through the meningeal lymphatic vessels ...
Anaïs Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Müller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe   +11 more
doaj   +2 more sources

Reconstructing cerebral lymphatic clearance: an emerging target in the Alzheimer's disease therapeutic pipeline. [PDF]

Alzheimers Dement
Abstract Neurotoxic protein accumulation is widely recognized as a key feature of Alzheimer's disease (AD), and increasing evidence indicates that impaired brain clearance associated with dysfunction of the meningeal lymphatic and glymphatic may contribute to this process.
Zhang J, Zhang J, Ding J, Zhang X, Wang Y, Wei W, Chai Y, Zhang S, Chen X.   +8 more
europepmc   +2 more sources

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Nature, 2019
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise ...
Hyunsoo Cho, Sang Heon Suh, Je-Seok Ham, Intae Park, Joo-Hye Song, Yong Jeong, Gou Young Koh, Jun-Hee Kim, Shin Heun Kim, Ji Hoon Ahn, Young-Kwon Hong, Seon Pyo Hong, Sung-Hong Park   +12 more
core   +3 more sources

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease. [PDF]

J Alzheimers Dis, 2023
Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the meninges, are the key drainage route responsible for the clearance of molecules, immune cells, and cellular debris from the cerebrospinal fluid and interstitial fluid into deep cervical lymph nodes.
Guo X, Zhang G, Peng Q, Huang L, Zhang Z, Zhang Z.   +5 more
europepmc   +3 more sources