Results 21 to 30 of about 353,217 (149)

How Do Meningeal Lymphatic Vessels Drain the CNS? [PDF]

Trends Neurosci, 2016
The many interactions between the nervous and the immune systems, which are active in both physiological and pathological states, have recently become more clearly delineated with the discovery of a meningeal lymphatic system capable of carrying fluid, immune cells, and macromolecules from the central nervous system (CNS) to the draining deep cervical ...
Raper D, Louveau A, Kipnis J.
europepmc   +4 more sources

Bidirectional roles of meningeal lymphatic vessels in brain metastases: friend and foe. [PDF]

Front Oncol
Brain metastases constitute the most prevalent intracranial malignancies. Despite recent therapeutic advances, patient prognoses remain poor, largely due to significant treatment resistance and a highly restrictive tumor microenvironment. The rediscovery of meningeal lymphatic vessels (MLVs) has provided new insights into how the brain interacts with ...
Shao W, Zhu E, Chen D, Lu H.
europepmc   +2 more sources

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels. [PDF]

Front Immunol, 2019
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the role of meningeal lymphatics in the pathogenesis of Alzheimer's disease and multiple sclerosis was ...
Bálint L, Ocskay Z, Deák BA, Aradi P, Jakus Z.   +4 more
europepmc   +6 more sources

The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception [PDF]

, 2022
A system of lymphatic vessels has been recently characterized in the meninges, with a postulated role in ‘cleaning’ the brain via cerebral fluid drainage.
Malm, Tarja, Mikhailov, Nikita, Hämäläinen, Riikka, H, Hämäläinen, Riikka,, Noe, Francesco, M, Tohka, Jussi, Giniatullin, Rashid, Giniatullina, Raisa, Gafurov, Oleg, Koroleva, Kseniia, Teleman, Matei, Krivoshein, Georgii, Sierra, Alejandra, Noe, Francesco M., Eme-Scolan, Elisa, Virenque, Anaïs, Hämäläinen, Riikka H., Abdollahzadeh, Ali, Noe, Francesco,, Rua, Rejane   +19 more
core   +1 more source

Podoplanin immunopositive lymphatic vessels at the implant interface in a rat model of osteoporotic fractures [PDF]

, 2013
Insertion of bone substitution materials accelerates healing of osteoporotic fractures. Biodegradable materials are preferred for application in osteoporotic patients to avoid a second surgery for implant replacement. Degraded implant fragments are often
Vivien Kauschke, Hartmann, Sonja, Alexander Langheinrich, Matthias Schumacher, Matthias Schnabelrauch, Hanke, Thomas, Heiss, Christian, Olaf Kilian, Kauschke, Vivien, Sonja Hartmann, Christian Heiss, Alt, Volker, Heinemann, Sascha, Marian Kampschulte, Kilian, Olaf, Thormann, Ulrich, Lips, Katrin Susanne, Langheinrich, Alexander, Schumacher, Matthias, Michael Gelinsky, Armin R Kautz, Seemun Ray, Volker Alt, Kautz, Armin R, Kampschulte, Marian, Katrin Susanne Lips, Gelinsky, Michael, Ray, Seemun, Schnettler, Reinhard, Sascha Heinemann, Reinhard Schnettler, Ulrich Thormann, Schnabelrauch, Matthias, Kautz, Armin R., Thomas Hanke   +34 more
core   +1 more source

Lymphatic vascular morphogenesis in development, physiology, and disease [PDF]

, 2011
The lymphatic vasculature constitutes a highly specialized part of the vascular system that is essential for the maintenance of interstitial fluid balance, uptake of dietary fat, and immune response. Recently, there has been an increased awareness of the
Amélie Sabine, Petrova, T.V., Stefan Schulte-Merker, Sabine, A., Schulte-Merker, S., Petrova, T. V., Tatiana V. Petrova   +6 more
core   +3 more sources

Tumor-induced myeloid cell plasticity toward lymphatic endothelium [PDF]

, 2009
Tumor-associated lymphangiogenesis contributes to tumor progression by regulating interstitial fluid pressure, transporting immune cells to the tumor site and providing a route for metastatic dissemination.
Baeriswyl, Vanessa
core   +1 more source

Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy. [PDF]

Light Sci Appl
AbstractMeningeal lymphatic vessels (mLVs) play a pivotal role in regulating metabolic waste from cerebrospinal fluid (CSF). However, the current limitations in field of view and resolution of existing imaging techniques impede understanding the stereoscopic morphology and dynamic behavior of mLVs in vivo.
Yang F, Wang Z, Shi W, Wang M, Ma R, Zhang W, Li X, Wang E, Xie W, Zhang Z, Shen Q, Zhou F, Yang S.   +12 more
europepmc   +4 more sources

A Role for All-Trans-Retinoic Acid in the Early Steps of Lymphatic Vasculature Development [PDF]

, 2010
The molecular mechanisms that regulate the earliest steps of lymphatic vascular system development are unknown. To identify regulators of lymphatic competence and commitment, we used an in vitro vascular assay with mouse embryonic stem cell-derived ...
Dabouras, Vasilios, Marino, Daniela, Vasilios Dabouras, Detmar, Michael, Braendli, Andre W., Michael Detmar, André W. Brändli, Daniela Marino   +7 more
core   +1 more source

DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease

, 2021
Highly developed meningeal lymphatics remove waste products from the brain. Disruption of meningeal lymphatic vessels in a mouse model of amyloid pathology (5XFAD) accelerates the accumulation of amyloid plaques in the meninges and brain, and causes ...
Park, Jiyoung, Kim, Hyerin, Min, Kyung-Tai, Choi, Chiyeol, Park, Jiwon, Chang, Karen T   +5 more
core   +1 more source