Results 41 to 50 of about 36,804 (221)

The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives. [PDF]

MedComm (2020)
Brain waste clearance relies on the anatomical and functional integration of the glymphatic system and meningeal lymphatic vessels. Cerebrospinal fluid influx into the brain parenchyma occurs along periarterial spaces, a process driven by polarized aquaporin‐4 (AQP4) water channels on astrocytic endfeet.
Sun H, Fan H, Zhou Y, Zhu H, Chen Y, Zhang R, Wang K, Pan Y, Zhang A.   +8 more
europepmc   +2 more sources

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
doaj   +2 more sources

Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI

eLife, 2017
Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta, Seung-Kwon Ha, Govind Nair, Pascal Sati, Nicholas J Luciano, Maryknoll Palisoc, Antoine Louveau, Kareem A Zaghloul, Stefania Pittaluga, Jonathan Kipnis, Daniel S Reich   +10 more
doaj   +3 more sources

Targeting Meningeal Lymphatic Vessels to Advance Stroke Therapy [PDF]

Aging and Disease
Meningeal lymphatic vessels (mLVs) have recently emerged as pivotal regulators of central nervous system homeostasis, orchestrating cerebrospinal fluid (CSF) drainage, metabolic waste clearance, and neuroimmune surveillance at the brain and meningeal ...
Yang Liu, Xiansheng Liu, Shihao Lin, Tao Lv, Zhipeng Xiao, Wenwu Liu, Heng Zhao, Shuang Liao, 张晓华, Qin Yun Hu   +9 more
openalex   +2 more sources

Impaired meningeal lymphatic vessel development worsens stroke outcome [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2019
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3) signaling for development.
Pavel Yanev, Katherine Poinsatte, Devon Hominick, Noor Khurana, Kielen R. Zuurbier, Marcus Berndt, Erik J. Plautz, Michael T. Dellinger, Ann Stowe   +8 more
openalex   +3 more sources

Meningeal lymphatics as a therapeutic target for neurodegenerative disorders [PDF]

Translational Neurodegeneration
Advancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune ...
Yijia Feng, Shengya Wang, Huwei Xia, Xinyi Jiang, Mingming Wu, Sipei Pan, Weihong Song   +6 more
doaj   +2 more sources

Influence of meningeal lymphatic vessels on brain mechanisms

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019
Masashi Matsuoka, Yasue Mitsukura, Tomoe Ishikawa, Masato Yasui   +3 more
openalex   +3 more sources

Meningeal lymphatic vessel dysfunction exacerbates brain injury in CVST mice via endoplasmic reticulum and oxidative stress pathways. [PDF]

Front Immunol
Ying J, Li J, Wu X, Chen X, Zhang H, Wei L, Jing J, Wang S.   +7 more
europepmc   +3 more sources

Faculty Opinions recommendation of Development and plasticity of meningeal lymphatic vessels.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2018
Richard Daneman, Marie Blanchette
openalex   +3 more sources

Gene expression in meningeal lymphatic endothelial cells following traumatic brain injury in mice.

PLoS ONE, 2022
Meningeal lymphatic vessels transport both the cerebrospinal fluid and interstitial fluid to the deep cervical lymph nodes. Traumatic brain injury (TBI) is accompanied by meningeal injury.
Ryo Shimada, Yuki Tatara, Kazuhiko Kibayashi   +2 more
doaj   +1 more source