Results 61 to 70 of about 373,387 (179)

Epistemological Anatomy: A Conceptual Framework for Understanding Anatomical Knowledge

Clinical Anatomy, EarlyView.
ABSTRACT Anatomy is often regarded as settled knowledge. Yet anatomical propositions differ enormously in their evidentiary foundations, while textbooks and atlases frequently present them with similar certainty. How, then, does an anatomical observation become anatomical knowledge? We introduce epistemological anatomy as a framework for the systematic
Marios Loukas, Joe Iwanaga, Mi‐Sun Hur, Seiichi Inoue, Mohammed K. Khalil, R. Shane Tubbs   +5 more
wiley   +1 more source

Phase coupling between eye and brain pulsations is bidirectional and modulated by the parasympathetic system – An fMREye study

Acta Ophthalmologica, EarlyView.
Abstract Purpose Physiological pulsations driven by cardiac, respiratory, and vasomotor activity are essential for solute transport within perivascular and perineural cerebrospinal fluid (CSF) pathways that support brain and eye clearance systems. Previous studies have shown that parasympathetic blockade significantly reduces ocular pulsation power and
Ebrahimi Seyed‐Mohsen, Väyrynen Tommi, Huotari Niko, Saarela Ville, Honkamo Marja, Helakari Heta, Järvelä Matti, Korhonen Vesa, Raitamaa Lauri, Kiviniemi Vesa   +9 more
wiley   +1 more source

The characteristics of perivascular proinflammation in 4‐repeat tauopathies

Brain Pathology, EarlyView.
The spatial distribution of perivascular proinflammation differs between PSP and CBD: PSP shows a predominance in basal ganglia (BG), whereas CBD demonstrates more widespread involvement of both BG and superior/middle frontal gyrus (S/M‐FG). PSP exhibits profound proinflammatory activation around venules while CBD affects a comparable magnitude around ...
Mu‐Hui Fu, Gokhan Uruk, Rodolfo G. Gatto, R. Ross Reichard, Jennifer L. Whitwell, Keith A. Josephs   +5 more
wiley   +1 more source

Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance

Diabetic Medicine, EarlyView.
In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little, Judith Lechner, Giulia De Rossi, Tara Cullen, Jennifer Perais, Eleni Beli, Noemi Lois, Alan W. Stitt   +7 more
wiley   +1 more source

The interaction between the meningeal lymphatics and blood-brain barrier

, 2018
Here we show the interaction between the meningeal lymphatic system and the blood-brain barrier (BBB) function. In normal state, the meningeal lymphatic vessels are invisible on optical coherent tomography (OCT), while during the opening of the BBB ...
Abdurashitov, Arkady S., Alla Bucharskaya, Dubrovsky, Alexander, Shushunova, Natalia A., Maslyakova, Galina N., Semyachkina-Glushkovskaya, Oxana V., Valery V. Tuchin, Natalia Shushunova, Oxana V. Semyachkina-Glushkovskaya, Pavlov, Alexey, Navolokin, Nikita A., Bucharskaya, Alla B., Galina Maslyakova, Nikita Navolokin, Kurths, Jürgen, Alexey Pavlov, Tuchin, Valery V., Alexander Dubrovsky, Juergen Kurths, Arkady Abdurashitov, Shushunova, N., Dubrovsky, A., Abdurashitov, Arkady   +22 more
core   +2 more sources

Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis)

Journal of Anatomy, Volume 246, Issue 4, Page 575-584, April 2025.
India ink introduced into the cranial cerebrospinal fluid (CSF) compartment of Alligator diffuses along the spinal cord and exits the spinal compartment using perineural flow, resulting in a prominent “ink cuff” forming at the base of the spinal nerve. In Alligator, the region of the ink cuff is drained by a small lymphatic vessel.
Hadyn DeLeeuw, Michael Cramberg, Matthew Dille, Emily Pick, Mary Thompson, Bruce A. Young   +5 more
wiley   +1 more source

Case report: meningeal lymphangiogenesis around ependymoma forming along the dura matter

Frontiers in Oncology
Recently, there has been growing interest in the presence and function of meningeal lymphatic vessels, with no direct evidence linking these vessels to primary brain tumors.
Utaro Hino, Ryota Tamura, Masahiro Yo, Yoshitaka Kase, Yoshitaka Kase, Noboru Tsuda, Tsubasa Miyauchi, Junki Sogano, Kosuke Karatsu, Tomoru Miwa, Masahiro Toda   +10 more
doaj   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Mural lymphatic endothelial cells regulate meningeal angiogenesis in the zebrafish

, 2017
Mural cells of the vertebrate brain maintain vascular integrity and function, play roles in stroke and are involved in maintenance of neural stem cells. However, the origins, diversity and roles of mural cells remain to be fully understood.
Francois, M., Scott Paterson, Mochizuki, Naoki, Hogan, Benjamin M., Pichol-Thievend, C., Isaac Virshup, Koltowska, Katarzyna, Hurley, D., Sungmin Baek, Bent, S., Cas Simons, Naoki Mochizuki, Rondon-Galeano, Maria, Bower, Neil I., Christine A Wells, Rondon-Galeano, M., Daniel G Hurley, Virshup, Isaac, Paterson, Scott, Virshup, I., Stephen J Bent, Wells, Christine A., Cathy Pichol-Thievend, Simons, C., Pichol-Thievend, Cathy, Wang, Weili, Simons, Cas, Anne K Lagendijk, Koltowska, K., Hogan, B., Weili Wang, Jan Kaslin, Kaslin, J., Mochizuki, N., Neil I Bower, Benjamin W Lindsey, Bent, Stephen J., Benjamin M Hogan, Lagendijk, Anne K., Katarzyna Koltowska, Maria Rondon-Galeano, Mathias Francois, Lindsey, Benjamin W., Paterson, S., Francois, Mathias, Baek, Sungmin, Wells, C., Bower, N., Hurley, Daniel G., Baek, S., Lindsey, B., Wang, W., Lagendijk, A., Kaslin, Jan   +53 more
core   +1 more source

sox17 Mutagenesis Reveals Compounding Effects ofMaternal and Zygotic Contribution on Microglia Abundance

Glia, Volume 75, Issue 1, January 2027.
sox17 is a maternal effect gene impacting microglia and microglia precursor abundance. sox17 mRNA injection timed to maternal contribution rescues abundance. A CRISPR screen reveals f11r.1, gas6, and mpp1 also regulate microglia abundance. ABSTRACT Embryonic development is shaped by maternal and zygotic factors but how the interplay between these ...
Camden A. Spring, John Dennen, Dailin Gan, Jun Li, Cody J. Smith   +4 more
wiley   +1 more source