Cells with Many Talents: Lymphatic Endothelial Cells in the Brain Meninges
Cells, 2021 The lymphatic system serves key functions in maintaining fluid homeostasis, the uptake of dietary fats in the small intestine, and the trafficking of immune cells. Almost all vascularized peripheral tissues and organs contain lymphatic vessels. The brain
Irina Suárez, Stefan Schulte-Merker
doaj +1 more source
Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation [PDF]
Nature NeuroscienceAbstract Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment ...
Dongwon Choi +15 more
openalex +3 more sources
Fluids and Barriers of the CNS, 2023 Background Despite greatly renewed interest concerning meningeal lymphatic function over recent years, the lymphatic structures of human dura mater have been less characterized. The available information derives exclusively from autopsy specimens.
César Luis Vera Quesada +3 more
doaj +1 more source
Widespread distribution of lymphatic vessels in human dura mater remote from sinus veins
Frontiers in Cell and Developmental Biology, 2023 Background and purpose: Previous experimental studies have shown that meningeal lymphatic vessels are located primarily along the walls of the dural sinus veins.
César Luis Vera Quesada +5 more
doaj +1 more source
Research Progress on Intracranial Lymphatic Circulation and Its Involvement in Disorders
Frontiers in Neurology, 2022 The lymphatic system is an important part of the circulatory system, as an auxiliary system of the vein, which has the functions of immune defense, maintaining the stability of the internal environment, and regulating the pressure of the tissue.
Fan Chen, Xuan Xie, Liang Wang
doaj +1 more source
Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice [PDF]
Journal of Clinical InvestigationMigraines are a type of headache that occur with other neurological symptoms, but the pathophysiology remains unclear. In this issue of the JCI, Nelson-Maney and authors used constitutive and inducible knockouts of the CGRP receptor components, elegantly demonstrating an essential function of CGRP in modulating meningeal lymphatic vessels (MLVs) in ...
Jean‐Léon Thomas +2 more
openalex +3 more sources
Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics [PDF]
Journal of Innovative Optical Health Sciences, 2020 Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain barrier (BBB) permeability open novel strategies for drug-brain delivery ...
A. Abdurashitov +2 more
doaj +1 more source
Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress
Research, 2023 Studies have demonstrated that a functional network of meningeal lymphatic vessels exists in the brain. However, it is unknown whether lymphatic vessels could also extend deep into the brain parenchyma and whether the vessels could be regulated by ...
Junzhuang Chang +6 more
doaj +1 more source
Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans [PDF]
Nature CommunicationsRegular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice. Here, we investigate the impact of physical exercise on both upstream and downstream brain waste clearance in healthy volunteers via noninvasive MR imaging.
Roh‐Eul Yoo +9 more
openalex +4 more sources
Tertiary lymphoid organs in central nervous system autoimmunity [PDF]
, 2016 Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation in the central nervous system (CNS), which results in permanent neuronal damage and substantial disability in patients.
Mitsdoerffer, M., Peters, A.
core +1 more source