Results 31 to 40 of about 6,220 (169)

Abstract 1122‐000183: Assessing Meningeal Lymphatic MRI Biomarkers in Acute Large Vessel Occlusion Stroke Treated with Thrombectomy

Stroke: Vascular and Interventional Neurology, 2021
Introduction: Until recently, there was very little known about the brain’s waste removal system. Unlike the peripheral organ systems, the CNS lacked a clearly defined lymphatic vasculature and waste clearance mechanism.
Richard Pham, Rano Chatterjee
doaj   +2 more sources

Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

Translational Neurodegeneration, 2019
Background Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson’s disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD.
Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Renhong Du, Ming Xiao, Gang Hu   +7 more
doaj   +2 more sources

Brain lymphatic vessels accompanying meningeal arteries in the human

Translational Research in Anatomy
Introduction: Recent studies showed the connection between cerebrospinal fluid (CSF) and deep cervical lymph nodes (dCLN) via lymphatic vessels (LV)s. These LVs accompany dural sinuses, cranial nerves, and arteries.
Safiye Çavdar, Damlasu Altınöz, Tevriz Dilan Demir, Acar Bayraktaroğlu, İlke Ali Gürses, Gülnihal Özcan   +5 more
doaj   +2 more sources

Spatiotemporal dynamic changes of meningeal microenvironment influence meningeal lymphatic function following subarachnoid hemorrhage: from inflammatory response to tissue remodeling

Journal of Neuroinflammation
Background Meningeal lymphatic vessels (mLVs) play a critical role in clearing erythrocytes from the subarachnoid space and immune cells from the brain parenchyma following subarachnoid hemorrhage (SAH). However, the drainage function of mLVs is impaired
Bingrui Zhu, Changming Liu, Ming Luo, Jiarui Chen, Sixuan Tian, Tiantong Zhan, Yibo Liu, Haocheng Zhang, Zhen Wang, Jianmin Zhang, Yuanjian Fang, Sheng Chen, Xiaoyu Wang   +12 more
doaj   +2 more sources

Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human

Annals of Neurology, 2020
OBJECTIVE: Aging is a major risk factor for numerous neurological disorders, and the mechanisms underlying brain aging remain elusive. Recent animal studies demonstrated a tight relationship between impairment of the glymphatic pathway, meningeal ...
Luo, Zhongyu, Jinsong Cai, Lou, Min, Shenqiang Yan, Xiaoxian Gong, Cai, Jinsong, Jiang, Quan, Zhou, Ying, Quan Jiang, Min Lou, Ying Zhou, Jianzhong Sun, Sun, Jianzhong, Zhang, Kemeng, Kemeng Zhang, Zhang, Wenhua, Yan, Shenqiang, Zhongyu Luo, Gong, Xiaoxian, Wenhua Zhang   +19 more
core   +3 more sources

Overview of the meningeal lymphatic vessels in aging and central nervous system disorders. [PDF]

Cell Biosci, 2022
AbstractIn the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even cerebrovascular disease. These findings reveal a new perspective on aging and CNS disorders and provide a
Jiang H, Wei H, Zhou Y, Xiao X, Zhou C, Ji X.   +5 more
europepmc   +4 more sources

Meningeal lymphatic vessels regulate brain tumor drainage and immunity. [PDF]

Cell Res, 2020
AbstractRecent studies have shown that meningeal lymphatic vessels (MLVs), which are located both dorsally and basally beneath the skull, provide a route for draining macromolecules and trafficking immune cells from the central nervous system (CNS) into cervical lymph nodes (CLNs), and thus represent a potential therapeutic target for treating ...
Hu X, Deng Q, Ma L, Li Q, Chen Y, Liao Y, Zhou F, Zhang C, Shao L, Feng J, He T, Ning W, Kong Y, Huo Y, He A, Liu B, Zhang J, Adams R, He Y, Tang F, Bian X, Luo J.   +21 more
europepmc   +4 more sources

Meningeal Lymphatic Vessels: A Drain of the Brain Involved in Neurodegeneration? [PDF]

Neurosci Bull, 2020
Cheng Y, Wang YJ, Wang YJ.
europepmc   +4 more sources

The Interplay between Meningeal Lymphatic Vessels and Neuroinflammation in Neurodegenerative Diseases. [PDF]

Curr Neuropharmacol
Abstract: Meningeal lymphatic vessels (MLVs) are essential for the drainage of cerebrospinal fluid, macromolecules, and immune cells in the central nervous system. They play critical roles in modulating neuroinflammation in neurodegenerative diseases. Dysfunctional MLVs have been demonstrated to increase neuroinflammation by horizontally blocking the ...
Chen J, Pan Y, Liu Q, Li G, Chen G, Li W, Zhao W, Wang Q.   +7 more
europepmc   +3 more sources

The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders. [PDF]

J Cereb Blood Flow Metab, 2022
The recent discovery of the meningeal lymphatic vessels (mLVs) and glymphatic pathways has challenged the long-lasting dogma that the central nervous system (CNS) lacks a lymphatic system and therefore does not interact with peripheral immunity. This discovery has reshaped our understanding of mechanisms underlying CNS drainage. Under normal conditions,
Li G, Cao Y, Tang X, Huang J, Cai L, Zhou L.   +5 more
europepmc   +3 more sources