Results 31 to 40 of about 34,570 (162)

Meningeal lymphatics as a therapeutic target for neurodegenerative disorders [PDF]

Translational Neurodegeneration
Advancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune ...
Yijia Feng, Shengya Wang, Huwei Xia, Xinyi Jiang, Mingming Wu, Sipei Pan, Weihong Song   +6 more
doaj   +2 more sources

Meningeal lymphatic dysfunction mediates postoperative sleep deprivation-induced cognitive decline via impaired neuroinflammatory clearance [PDF]

Journal of Neuroinflammation
Postoperative sleep deprivation (PSD) exacerbates perioperative neurocognitive disorders (PND) through unresolved neuroinflammation, yet the underlying mechanisms remain elusive.
Binkang Huang, Wei Tu, Han Zhou, Lan Mo, Qiubo Yang, Yilong Sheng, Daofan Sun, Bo Meng, Zhexi Chi, Yingying Lv, Rongjun Liu, Xiuzhong Xing, Hui Yuan, Jing Yang, Fengdeng Hu, Guo Chen, Junping Chen, Xiaowei Chen, Bo Lu   +18 more
doaj   +2 more sources

How Do Meningeal Lymphatic Vessels Drain the CNS? [PDF]

Trends Neurosci, 2016
The many interactions between the nervous and the immune systems, which are active in both physiological and pathological states, have recently become more clearly delineated with the discovery of a meningeal lymphatic system capable of carrying fluid, immune cells, and macromolecules from the central nervous system (CNS) to the draining deep cervical ...
Raper D, Louveau A, Kipnis J.
europepmc   +4 more sources

Gene expression in meningeal lymphatic endothelial cells following traumatic brain injury in mice.

PLoS ONE, 2022
Meningeal lymphatic vessels transport both the cerebrospinal fluid and interstitial fluid to the deep cervical lymph nodes. Traumatic brain injury (TBI) is accompanied by meningeal injury.
Ryo Shimada, Yuki Tatara, Kazuhiko Kibayashi   +2 more
doaj   +1 more source

Cells with Many Talents: Lymphatic Endothelial Cells in the Brain Meninges

Cells, 2021
The lymphatic system serves key functions in maintaining fluid homeostasis, the uptake of dietary fats in the small intestine, and the trafficking of immune cells. Almost all vascularized peripheral tissues and organs contain lymphatic vessels. The brain
Irina Suárez, Stefan Schulte-Merker
doaj   +1 more source

Immunohistochemical visualization of lymphatic vessels in human dura mater: methodological perspectives

Fluids and Barriers of the CNS, 2023
Background Despite greatly renewed interest concerning meningeal lymphatic function over recent years, the lymphatic structures of human dura mater have been less characterized. The available information derives exclusively from autopsy specimens.
César Luis Vera Quesada, Shreyas Balachandra Rao, Reidun Torp, Per Kristian Eide   +3 more
doaj   +1 more source

Widespread distribution of lymphatic vessels in human dura mater remote from sinus veins

Frontiers in Cell and Developmental Biology, 2023
Background and purpose: Previous experimental studies have shown that meningeal lymphatic vessels are located primarily along the walls of the dural sinus veins.
César Luis Vera Quesada, César Luis Vera Quesada, Shreyas Balachandra Rao, Reidun Torp, Per Kristian Eide, Per Kristian Eide   +5 more
doaj   +1 more source

Research Progress on Intracranial Lymphatic Circulation and Its Involvement in Disorders

Frontiers in Neurology, 2022
The lymphatic system is an important part of the circulatory system, as an auxiliary system of the vein, which has the functions of immune defense, maintaining the stability of the internal environment, and regulating the pressure of the tissue.
Fan Chen, Xuan Xie, Liang Wang
doaj   +1 more source

Impaired meningeal lymphatic vessel development worsens stroke outcome [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2019
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3) signaling for development. Here we characterize the effect of stroke on meningeal LVs,
Yanev, Pavel, Poinsatte, Katherine, Hominick, Devon, Khurana, Noor, Zuurbier, Kielen R, Berndt, Marcus, Plautz, Erik J, Dellinger, Michael T, Stowe, Ann M   +8 more
openaire   +2 more sources

Characteristic Features of Deep Brain Lymphatic Vessels and Their Regulation by Chronic Stress

Research, 2023
Studies have demonstrated that a functional network of meningeal lymphatic vessels exists in the brain. However, it is unknown whether lymphatic vessels could also extend deep into the brain parenchyma and whether the vessels could be regulated by ...
Junzhuang Chang, Bingqing Guo, Yan Gao, Wei Li, Xiaoyu Tong, Yi Feng, Nashat Abumaria   +6 more
doaj   +1 more source