Results 11 to 20 of about 36,804 (221)

The Underlying Role of the Glymphatic System and Meningeal Lymphatic Vessels in Cerebral Small Vessel Disease [PDF]

Biomolecules, 2022
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most research has suggested that cerebral small vessel disease (CSVD) is the main contributor to VCI. Several potential physiopathologic mechanisms have been proven to be
Yu Tian, Mengxi Zhao, Yiyi Chen, Mo Yang, Yilong Wang   +4 more
doaj   +9 more sources

Role of meningeal lymphatic vessels in brain homeostasis [PDF]

Frontiers in Immunology
Meningeal lymphatic vessels (MLVs) form an important bridging structure between the brain and periphery, which drains cerebral metabolites in cerebrospinal fluid (CSF) and brain antigens to deep cervical lymph nodes (dCLNs), to maintain brain homeostasis.
Meng-Ying Zhao, Chao-Yuan Ye, Yuan-Cheng Liu, Xiao-Ming Wang, Jun-Cai Fu, Xin-Yuan Liu, Rui Zhu, Yi-Zhao Li, Qing Tian   +8 more
doaj   +6 more sources

Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels [PDF]

Acta Neuropathologica Communications, 2020
Subdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now.
Xuanhui Liu, Chuang Gao, Jiangyuan Yuan, Tangtang Xiang, Zhitao Gong, Hongliang Luo, Weiwei Jiang, Yiming Song, Jinhao Huang, Wei Quan, Dong Wang, Ye Tian, Xintong Ge, Ping Lei, Jianning Zhang, Rongcai Jiang   +15 more
doaj   +7 more sources

Development and plasticity of meningeal lymphatic vessels. [PDF]

J Exp Med, 2017
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance.
Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, Alitalo K.   +15 more
europepmc   +9 more sources

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels [PDF]

Frontiers in Immunology, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint, László Bálint, Zsombor Ocskay, Zsombor Ocskay, Bálint András Deák, Bálint András Deák, Petra Aradi, Petra Aradi, Zoltán Jakus, Zoltán Jakus   +9 more
doaj   +8 more sources

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease. [PDF]

J Alzheimers Dis, 2023
Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the meninges, are the key drainage route responsible for the clearance of molecules, immune cells, and cellular debris from the cerebrospinal fluid and interstitial fluid into
Guo X, Zhang G, Peng Q, Huang L, Zhang Z, Zhang Z.   +5 more
europepmc   +6 more sources

Metal-Supramolecular Drug Delivery System Empowered Meningeal Lymphatic Vessels-Bridged Intracranial-Peripheral Dual Immune Modulation for Reversing Glioblastoma Immune Suppression. [PDF]

Adv Sci (Weinh)
Glioblastoma (GBM) presents significant challenges in treatment due to the presence of the blood‐brain barrier (BBB) and immunosuppressive tumor microenvironment (TME).
Zhang C, Xu Z, Xu X, Zhang Z, Luo R, Ren P, Luo Y, Wu Q, Liu X, Liu G, He X, Liu Y.   +11 more
europepmc   +4 more sources

Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy. [PDF]

Light Sci Appl
Meningeal lymphatic vessels (mLVs) play a pivotal role in regulating metabolic waste from cerebrospinal fluid (CSF). However, the current limitations in field of view and resolution of existing imaging techniques impede understanding the stereoscopic ...
Yang F, Wang Z, Shi W, Wang M, Ma R, Zhang W, Li X, Wang E, Xie W, Zhang Z, Shen Q, Zhou F, Yang S.   +12 more
europepmc   +7 more sources

Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson's Disease. [PDF]

Research (Wash D C), 2023
Targeted therapy of Parkinson’s disease is an important challenge because of the blood–brain barrier limitation. Here, we propose a natural killer cell membrane biomimetic nanocomplex (named BLIPO-CUR) delivered via the meningeal lymphatic vessel (MLV ...
Liu J, Gao D, Hu D, Lan S, Liu Y, Zheng H, Yuan Z, Sheng Z.   +7 more
europepmc   +7 more sources

Meningeal lymphatic vessels regulate brain tumor drainage and immunity. [PDF]

Cell Res, 2020
Recent studies have shown that meningeal lymphatic vessels (MLVs), which are located both dorsally and basally beneath the skull, provide a route for draining macromolecules and trafficking immune cells from the central nervous system (CNS) into cervical
Hu X, Deng Q, Ma L, Li Q, Chen Y, Liao Y, Zhou F, Zhang C, Shao L, Feng J, He T, Ning W, Kong Y, Huo Y, He A, Liu B, Zhang J, Adams R, He Y, Tang F, Bian X, Luo J.   +21 more
europepmc   +6 more sources