Results 11 to 20 of about 353,217 (149)

Impaired Meningeal Lymphatic Vessel Development Worsens Stroke Outcome [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2020
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3 ...
Hominick, Devon, Khurana, Noor, Yanev, Pavel, Berndt, Marcus, Dellinger, Michael T., Zuurbier, Kielen R., Plautz, Erik J., Poinsatte, Katherine, Stowe, Ann M.   +8 more
core   +4 more sources

Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid

Nature, 2019
© 2019, The Author(s), under exclusive licence to Springer Nature Limited.Recent work has shown that meningeal lymphatic vessels (mLVs), mainly in the dorsal part of the skull, are involved in the clearance of cerebrospinal fluid (CSF), but the precise ...
Hyunsoo Cho, Sang Heon Suh, Je-Seok Ham, Intae Park, Joo-Hye Song, Yong Jeong, Gou Young Koh, Jun-Hee Kim, Shin Heun Kim, Ji Hoon Ahn, Young-Kwon Hong, Seon Pyo Hong, Sung-Hong Park   +12 more
core   +4 more sources

Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease. [PDF]

J Alzheimers Dis, 2023
Meningeal lymphatic vessels (mLVs), the functional lymphatic system present in the meninges, are the key drainage route responsible for the clearance of molecules, immune cells, and cellular debris from the cerebrospinal fluid and interstitial fluid into deep cervical lymph nodes.
Guo X, Zhang G, Peng Q, Huang L, Zhang Z, Zhang Z.   +5 more
europepmc   +3 more sources

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice. [PDF]

J Clin Invest, 2023
Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance.
Matrongolo MJ, Ang PS, Wu J, Jain A, Thackray JK, Reddy A, Sung CC, Barbet G, Hong YK, Tischfield MA.   +9 more
europepmc   +2 more sources

Overview of the meningeal lymphatic vessels in aging and central nervous system disorders. [PDF]

Cell Biosci, 2022
AbstractIn the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even cerebrovascular disease. These findings reveal a new perspective on aging and CNS disorders and provide a
Jiang H, Wei H, Zhou Y, Xiao X, Zhou C, Ji X.   +5 more
europepmc   +4 more sources

Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels. [PDF]

Acta Neuropathol Commun, 2020
AbstractSubdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. The meningeal lymphatic vessel (mLV) drainage pathway is a novel system that takes part in the clearance of waste products in the ...
Liu X, Gao C, Yuan J, Xiang T, Gong Z, Luo H, Jiang W, Song Y, Huang J, Quan W, Wang D, Tian Y, Ge X, Lei P, Zhang J, Jiang R.   +15 more
europepmc   +5 more sources

Meningeal lymphatic vessels regulate brain tumor drainage and immunity. [PDF]

Cell Res, 2020
AbstractRecent studies have shown that meningeal lymphatic vessels (MLVs), which are located both dorsally and basally beneath the skull, provide a route for draining macromolecules and trafficking immune cells from the central nervous system (CNS) into cervical lymph nodes (CLNs), and thus represent a potential therapeutic target for treating ...
Hu X, Deng Q, Ma L, Li Q, Chen Y, Liao Y, Zhou F, Zhang C, Shao L, Feng J, He T, Ning W, Kong Y, Huo Y, He A, Liu B, Zhang J, Adams R, He Y, Tang F, Bian X, Luo J.   +21 more
europepmc   +4 more sources

Meningeal Lymphatic Vessels: A Drain of the Brain Involved in Neurodegeneration? [PDF]

Neurosci Bull, 2020
Cheng Y, Wang YJ, Wang YJ.
europepmc   +4 more sources

Evaluation of meningeal lymphatic vessels with delayed contrast enhanced vessel-wall MRI in cerebral infarction. [PDF]

Jpn J Radiol
Abstract Purpose Observation of the clearance of gadolinium-based contrast agents (GBCA) in patients with cerebral infarction and Moyamoya disease (MMD) using vessel-wall MRI (VW-MRI). Methods This prospective study ...
Umehana M, Fushimi Y, Okuchi S, Otani S, Yamamoto T, Sakata A, Nakajima S, Ikeda S, Ito S, Grinstead J, Ahn S, Mitsumoto K, Ueno K, Wu CH, Miura S, Maki T, Chihara H, Funaki T, Arakawa Y, Nakamoto Y.   +19 more
europepmc   +6 more sources

The meningeal lymphatic vessels and the glymphatic system: Potential therapeutic targets in neurological disorders. [PDF]

J Cereb Blood Flow Metab, 2022
The recent discovery of the meningeal lymphatic vessels (mLVs) and glymphatic pathways has challenged the long-lasting dogma that the central nervous system (CNS) lacks a lymphatic system and therefore does not interact with peripheral immunity. This discovery has reshaped our understanding of mechanisms underlying CNS drainage. Under normal conditions,
Li G, Cao Y, Tang X, Huang J, Cai L, Zhou L.   +5 more
europepmc   +3 more sources