Results 71 to 80 of about 34,570 (162)

Blocking meningeal lymphatic drainage aggravates Parkinson’s disease-like pathology in mice overexpressing mutated α-synuclein

Translational Neurodegeneration, 2019
Background Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis of Parkinson’s disease (PD), thus, it is reliable to promote the clearance of α-synuclein to prevent and treat PD.
Wenyan Zou, Tinglin Pu, Weixi Feng, Ming Lu, Ying Zheng, Renhong Du, Ming Xiao, Gang Hu   +7 more
doaj   +1 more source

Infection control in the brain and the eye

Acta Ophthalmologica, Volume 104, Issue 5, Page e478-e490, August 2026.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

Analyzing the Feasibility of Surgical Approaches to Improve Cerebral Lymphatic Circulation in Alzheimer Disease

Guoji laonian yixue zazhi
Traditionally, it was believed that the human brain lacked lymphatic vessels. However, recent studies have progressively confirmed the existence of meningeal lymphatic vessels and the glymphatic system.
Zhao Yangguang, Li Xia, Fang Yuan, Zhang Yonghong, Ren Zhenhu   +4 more
doaj   +1 more source

Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 2, August 2026.
ABSTRACT Chemokines constitute a versatile signalling network maintaining homeostasis and glia–neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemokine systems transition from tightly regulated homeostatic signals to drivers of chronic neuroinflammation
Blanca I. Aldana, Kristine Freude
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 7, Page 1433-1442, July 2026.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Bundle structures inside the deep cervical lymphatic vessels of mice

Scientific Reports
The lymphatic system plays a crucial role in immune function and the removal of cellular waste. Recent studies have highlighted the presence of primo vessels (PVs) inside lymphatic vessels, distinct from conventional lymphatic tissues, yet their ...
Joonyoung Shin, Sungchul Kim
doaj   +1 more source

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Poor sleep is associated with neurodegenerative disease, but mechanisms are unclear. Greater volume of the choroid plexus (ChP), a brain structure supporting neurotoxic waste clearance, is linked to neurodegeneration and cognitive decline.
Miranda G. Chappel‐Farley, Kelsey R. Sewell, Audrey M. Collins, Cristina Molina‐Hidalgo, Shivangi Jain, Haiqing Huang, Patricio Solis‐Urra, Lauren E. Oberlin, George Grove, Arthur F. Kramer, Edward McAuley, Jeffrey M. Burns, Charles Hillman, Eric D. Vidoni, Bradley P. Sutton, Anna L. Marsland, M. Ilyas Kamboh, Chaeryon Kang, Lu Wan, Kirk I. Erickson, Kristine A. Wilckens   +20 more
wiley   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Global survey on the utilisation and experiences with different retrobulbar anaesthesia techniques in horses

Equine Veterinary Journal, Volume 58, Issue 4, Page 1091-1102, July 2026.
Abstract Background Retrobulbar anaesthesia (RBA) is relevant for ocular surgery in standing sedated horses. Objectives Gathering insights on experiences with RBA techniques. Study Design Cross‐sectional survey. Methods An online survey collected information on the respondents' professional background, indications, injection methods, use of ultrasound ...
Simona Lieberth, Katharina Thieme, Christian Dancker, Roswitha Merle, Johanna Corinna Eule   +4 more
wiley   +1 more source

Choroid plexus remodeling linked to impaired CSF‐mediated clearance and Alzheimer's disease progression

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Impaired cerebrospinal fluid (CSF) ‐mediated clearance has been implicated in Alzheimer's disease (AD), but how choroid plexus (ChP) remodeling relates to these processes in vivo remains incompletely understood. METHODS In a large ADNI cohort, we integrated structural magnetic resonance imaging (MRI), amyloid/tau positron emission
Haolin Yin, Yuepeng Deng, ZiHao Lu, Yu Jiang, Chao Zuo, Jianyu Li, Linlin Guo, Binwu Ying, Giuseppe Battaglia, Xiaohe Tian, Qiyong Gong, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +11 more
wiley   +1 more source