Results 71 to 80 of about 36,804 (221)

Lymphatic vessels of the dura mater: A new discovery? [PDF]

, 2015
Two recent paper s (Aspelund et al. 2015; Louveau et al. 2015) reported the presence in mice of lymphatics in the cerebra l dura mater , the most external of the meningeal layers covering the brain.
Bucchieri, F., Cappello, F., Farina, F., Zummo, G.   +3 more
core   +1 more source

The lymphatic drainage systems in the brain: a novel target for ischemic stroke?

Neural Regeneration Research, 2023
Recent studies have proposed three lymphatic drainage systems in the brain, that is, the glymphatic system, the intramural periarterial drainage pathway, and meningeal lymphatic vessels, whose roles in various neurological diseases have been widely ...
Ying-Jie Wang, Yan-Rong Sun, Yan-Hong Pei, Hao-Wen Ma, Ya-Kun Mu, Li-Hua Qin, Jun-Hao Yan   +6 more
doaj   +1 more source

rTMS treatment for abrogating intracerebral hemorrhage‐induced brain parenchymal metabolite clearance dysfunction in male mice by regulating intracranial lymphatic drainage

Brain and Behavior, 2023
Background The discovery of the glymphatic system and meningeal lymphatic vessels challenged the traditional view regarding the lack of a lymphatic system in the central nervous system.
Yuheng Liu, Xuanhui Liu, Pengju Sun, Jing Li, Meng Nie, Junjie Gong, Anqi He, Mingyu Zhao, Chen Yang, Zengguang Wang   +9 more
doaj   +1 more source

Significance of developmental meningeal lymphatic dysfunction in experimental post-traumatic injury

Brain, Behavior, & Immunity - Health, 2022
Understanding the pathological mechanisms unfolding after chronic traumatic brain injury (TBI) could reveal new therapeutic entry points. During the post-TBI sequel, the involvement of cerebrospinal fluid drainage through the meningeal lymphatic vessels ...
Anaïs Virenque, Hennariikka Koivisto, Salli Antila, Emma Zub, Erin Jane Rooney, Diana Miszczuk, Adrian Müller, Enija Stoka, Nicola Marchi, Kari Alitalo, Heikki Tanila, Francesco Mattia Noe   +11 more
doaj   +1 more source

Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases

Frontiers in Cellular Neuroscience, 2021
The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu, Collin Laaker, Matyas Sandor, Zsuzsanna Fabry   +3 more
doaj   +1 more source

Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow [PDF]

, 2019
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.
A Destexhe, A Louveau, A R Gardner-Medwin, AJ Smith, AS Thrane, B Frankenhaeuser, B Lu, BJ Tully, BV Safronov, C Nicholson, C Silberstein, CL Lopreore, CS Furman, DD Wang, E Lothman, E Syková, EA Newman, EA Newman, EH Park, ER Kandel, G Cordingley, G Einevoll, G Florence, G Halnes, G Halnes, G Rutkowska, G Ullah, Geir Halnes, Geir Halnes, GG Somjen, GG Somjen, H Kager, H Kager, H Zhang, HD Lux, I Østby, I. Dietzel, J Keyser De, J Pods, J Sibille, J Tong, J Ziburkus, JC Vardakis, JJ Iliff, JONATHAN A. COLES, JS Jung, K Støverud, K. Baber, KC Chen, L Hertz, L Odette, L Xie, L Øyehaug, M Amiry-Moghaddam, M Bai, M Hashido, M Léonetti, M Nedergaard, MA Biot, Matti Hämäläinen, MS Jensen, N Hübel, N Kríz, N Macaulay, N Qian, NN Haj-Yasein, NN Haj-Yasein, P Kofuji, Paul L. Nunez, PM Nanninga, R Enger, RK Orkand, Rune Enger, SB Hladky, T Grisar, Tina Pangršič, Y Zhang   +76 more
core   +2 more sources

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]

, 2018
Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim, Holtzman, David M, Ma, Qingyi, Owens, Nelly Chuqui, Sagare, Abhay P, Verghese, Philip B, Wang, Min, Wu, Yingxi, Zhao, Zhen, Zlokovic, Berislav V   +9 more
core   +3 more sources

Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms [PDF]

, 2018
Incomplete delivery to the target cells is an obstacle for successful gene therapy approaches. Here we show unexpected effects of incomplete targeting, by demonstrating how heterogeneous inhibition of a growth promoting signaling pathway promotes tissue ...
Alitalo, Kari, Frye, Maike, Martinez-Corral, Ines, Mäkinen, Taija, Stanczuk, Lukas, Ulvmar, Maria H., Zhang, Yan   +6 more
core   +1 more source

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Spontaneous activity in peripheral diaphragmatic lymphatic loops. [PDF]

, 2013
The spontaneous contractility of FITC-dextran-filled lymphatics at the periphery of the pleural diaphragm was documented for the first time “in vivo” in anesthetized Wistar rats. We found that lymphatic segments could be divided into four phenotypes: 1)
Marcozzi C, Moriondo A, Negrini D, Solari E   +3 more
core   +1 more source