Results 91 to 100 of about 34,570 (162)

Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice

Nature Communications
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Miao Wang, Congcong Yan, Xi Li, Tianhao Yang, Shengnan Wu, Qian Liu, Qingming Luo, Feifan Zhou   +7 more
doaj   +1 more source

Photoacoustic detecting of brain lymphatic dysfunction in inflammatory models

Journal of Innovative Optical Health Sciences
The brain lymphatic system plays a crucial role in maintaining homeostasis, clearing metabolic waste, and regulating neuroinflammation. Its dysfunction is strongly linked to neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease ...
Meng Wang, Dan Wang, Zhigang Wang, Wenbin Shi, Zhiyang Wang   +4 more
doaj   +1 more source

The meningeal lymphatic vessel–peripheral immune axis: a novel therapeutic target in neurodegenerative diseases

Journal of Neuroinflammation
Meningeal lymphatic vessels serve as a direct anatomical conduit connecting the central nervous system and the peripheral immune system, fundamentally challenging the traditional view of the brain as an "immune-privileged" organ.
Zhidong He, Jing Sun
doaj   +1 more source

Deep brain lymphatic vessels: a new player in brain functions, neurodegenerative diseases and psychiatric disorders

Stress and Brain
The brain was previously believed to be an “immune privileged” organ without an immune system. However, recent discoveries have shown a connection between the peripheral lymphatic system and the brain.
Bingqing Guo, Junzhuang Chang, Nashat Abumaria   +2 more
doaj   +1 more source

Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells

Nature Communications
The meninges are critical for the brain functions, but the diversity of meningeal cell types and intercellular interactions have yet to be thoroughly examined. Here we identify a population of meningeal lymphatic supporting cells (mLSCs) in the zebrafish
Xiang He, Daiqin Xiong, Lei Zhao, Jialong Fu, Lingfei Luo   +4 more
doaj   +1 more source

Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review

Frontiers in Immunology
Glymphatic transport, meningeal lymphatic drainage, and meningeal immunity have been implicated in metabolic waste clearance, cerebral edema formation, and the regulation of neuroinflammation after stroke.
Yuyin Han, Yuyin Han, Boran Dong, Shuhao Mei, Shuhao Mei, Hailian Yi, Hailian Yi, Meiting Li, Meiting Li, Mengyan Sun, Mengyan Sun, Wenzhen Zhuo, Wenzhen Zhuo, Han Wang, Han Wang, Yong Liu, Xiaoyang Gong   +16 more
doaj   +1 more source

Influence of meningeal lymphatic vessels on brain mechanisms

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019
Masashi Matsuoka, Yasue Mitsukura, Tomoe Ishikawa, Masato Yasui   +3 more
openaire   +2 more sources

Impairment of the intracranial lymphatic system in Parkinson’s disease: a combined study of the meningeal lymphatics vessels and glymphatic system based on noninvasive neuroimaging

European Journal of Medical Research
Abstract Background: The role of intracranial lymphatic circulation in Parkinson's disease (PD) causes more and more concerns nowadays. The drainage function of meningeal lymphatic vessels (MLVs) and the clearance capability of the glymphatic system have been demonstrated to associate with development of PD.
Huang, Mingxian, Zhang, Pan, Chen, Zhen, Wang, Xiaoyang, Li, Hui, Xu, Shangwen, Lan, Limin, Zheng, Wenxi, Xiao, Hui   +8 more
openaire   +2 more sources

Long-term physical exercise facilitates putative glymphatic and meningeal lymphatic vessel flow in humans

Nature Communications
Regular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice. Here, we investigate the impact of physical exercise on both upstream and downstream brain waste clearance in healthy volunteers via noninvasive MR imaging.
Roh-Eul Yoo, Jun-Hee Kim, Hyo Youl Moon, Jae Yeon Park, Seongmin Cheon, Hyun-Suk Shin, Dohyun Han, Yukyoum Kim, Sung-Hong Park, Seung Hong Choi   +9 more
openaire   +3 more sources

Bone Marrow Derived Myeloid Cells Regulate Meningeal Lymphatic Vessel Development

Meningeal lymphatic vessels (mLVs) in the dura mater drain cerebrospinal fluid and toxic brain waste out of the central nervous system to maintain brain health. mLVs develop postnatally, and macrophages are associated with developing mLVs. Since monocytes replenish dural macrophages, we hypothesized that monocytes differentiate into macrophages to ...
openaire   +1 more source