Results 101 to 110 of about 6,220 (169)

Dural Macrophages in The Regulation of Meningeal Lymphatic Vessel Structure and Brain Lymph Drainage

, 2023
Meningeal lymphatic vessels (mLVs) are the primary route for cerebrospinal fluid (CSF) outflow from the brain. Importantly, dysfunction of mLVs in mice has been shown to increase toxic protein accumulation, resulting in a decline in neurocognitive processing.
openaire   +2 more sources

Targeting Meningeal Lymphatic Vessels to Advance Stroke Therapy

aging and disease
Meningeal lymphatic vessels (mLVs) have recently emerged as pivotal regulators of central nervous system homeostasis, orchestrating cerebrospinal fluid (CSF) drainage, metabolic waste clearance, and neuroimmune surveillance at the brain and meningeal interface.
openaire   +1 more source

Incorporating meningeal immunity into vaccine development

Nature Communications
Meningeal immunity, a less-studied aspect of neuroimmune interactions, has recently come under the spotlight owing to the characterization of meningeal lymphatic vessels draining of the central nervous system (CNS).
Manisha Menon, Colin N. Haile, David J. Dowling   +2 more
doaj   +1 more source

Meningeal Lymphatic and Glymphatic Structures in a Pelagic Delphinid (Delphinus delphis)

The glymphatic system, an analog of the peripheral lymphatic system in the brain, and the meningeal lymphatic system are critical to central nervous system health.
Kernagis, Dawn N., Keenan, Tiffany F., Nelson-Maney, Nathan P., Rotstein, David S., Harms, Craig A., Schweikert, Lorian E., Braun, Molly, Tift, Michael S., McLellan, William A., Rommel, Sentiel A., Doshkov, Paul, Jackson, Olivia N., Piscitelli-Doshkov, Marina A., Thayer, Victoria G., Caron, Kathleen M., Pabst, D. Ann, Costidis, Alexander M., Yopak, Kara E.   +17 more
core   +1 more source

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

The Journal of Clinical Investigation
Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance.
Matt J. Matrongolo, Phillip S. Ang, Junbing Wu, Aditya Jain, Joshua K. Thackray, Akash Reddy, Chi Chang Sung, Gaëtan Barbet, Young-Kwon Hong, Max A. Tischfield   +9 more
doaj   +1 more source

Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice

Nature Communications
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Miao Wang, Congcong Yan, Xi Li, Tianhao Yang, Shengnan Wu, Qian Liu, Qingming Luo, Feifan Zhou   +7 more
doaj   +1 more source

Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson's Disease. [PDF]

Research (Wash D C), 2023
Liu J, Gao D, Hu D, Lan S, Liu Y, Zheng H, Yuan Z, Sheng Z.   +7 more
europepmc   +1 more source

Photoacoustic detecting of brain lymphatic dysfunction in inflammatory models

Journal of Innovative Optical Health Sciences
The brain lymphatic system plays a crucial role in maintaining homeostasis, clearing metabolic waste, and regulating neuroinflammation. Its dysfunction is strongly linked to neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease ...
Meng Wang, Dan Wang, Zhigang Wang, Wenbin Shi, Zhiyang Wang   +4 more
doaj   +1 more source

Deep brain lymphatic vessels: a new player in brain functions, neurodegenerative diseases and psychiatric disorders

Stress and Brain
The brain was previously believed to be an “immune privileged” organ without an immune system. However, recent discoveries have shown a connection between the peripheral lymphatic system and the brain.
Bingqing Guo, Junzhuang Chang, Nashat Abumaria   +2 more
doaj   +1 more source

Characterization of meningeal lymphatic vessels in physiological and pathological conditions

, 2023
Meningeal lymphatic vessels (mLVs) have been recently characterized in the meninges surrounding the brain and the spinal cord. Experimental evidence indicates that these vessels are part of the drainage routes for CNS fluids (cerebrospinal fluid – CSF ...
Virenque, Anaïs
core