Results 101 to 110 of about 373,387 (179)

Characterizing Intracranial Lymphatic Development in Zebrafish

, 2020
The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of fluid homeostasis and cellular waste management in the brain.
Bakary Samasa (8722090), Van N. Pham (8722114), Daniel Castranova (8722097), Hyun Min Jung (2323360), Marina Venero Galanternik (8722112), Brant M Weinstein (37722)   +5 more
core   +1 more source

Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: prospects and challenges

Frontiers in Cell and Developmental Biology
The brain has traditionally been considered an “immune-privileged” organ lacking a lymphatic system. However, recent studies have challenged this view by identifying the presence of the glymphatic system and meningeal lymphatic vessels (MLVs).
Rui Zhang, Jiuhong Li, Xueying Li, Si Zhang   +3 more
doaj   +1 more source

Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation

Nature Neuroscience
Abstract Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment ...
Dongwon Choi, Eunkyung Park, Joshua Choi, Renhao Lu, Jin Suh Yu, Chiyoon Kim, Luping Zhao, James Yu, Brandon Nakashima, Sunju Lee, Dhruv Singhal, Joshua P. Scallan, Bin Zhou, Chester J. Koh, Esak Lee, Young-Kwon Hong   +15 more
openaire   +2 more sources

Dural Macrophages in The Regulation of Meningeal Lymphatic Vessel Structure and Brain Lymph Drainage

, 2023
Meningeal lymphatic vessels (mLVs) are the primary route for cerebrospinal fluid (CSF) outflow from the brain. Importantly, dysfunction of mLVs in mice has been shown to increase toxic protein accumulation, resulting in a decline in neurocognitive processing.
openaire   +2 more sources

The Function of VEGFR3 Signaling Pathway and Meningeal Lymphatic Vessels in Alzheimer’s disease Mouse Model

, 2020
Alzheimerin tauti on yleisin dementian muoto ja maailmanlaajuisesti yksi yleisimmistä kuolemansyistä. Imusuonien löytyminen keskushermostoa ympäröivältä uloimmalta aivokalvolta, kovakalvolta, on tuonut uuden näkökulman neurologisten tautien tutkimukseen.
Näsi, Anni
core  

Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

The Journal of Clinical Investigation
Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance.
Matt J. Matrongolo, Phillip S. Ang, Junbing Wu, Aditya Jain, Joshua K. Thackray, Akash Reddy, Chi Chang Sung, Gaëtan Barbet, Young-Kwon Hong, Max A. Tischfield   +9 more
doaj   +1 more source

Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice

Nature Communications
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Miao Wang, Congcong Yan, Xi Li, Tianhao Yang, Shengnan Wu, Qian Liu, Qingming Luo, Feifan Zhou   +7 more
doaj   +1 more source

The emerging role of the meningeal lymphatic and glymphatic systems in migraine pathophysiology: a systematic review

The Journal of Headache and Pain
Background/objective Migraine is a common, debilitating neurological disorder of unclear pathophysiology. Recent evidence has implicated impaired meningeal lymphatic function and its interaction with the glymphatic system in the development of ...
Kimia Bagheri, Hadi Sahrai, Negin Safari Dehnavi, Niloofar Taheri, Ali Norouzi, Mahnaz Talebi, Reza Mosaddeghi-Heris, Amirreza Naseri   +7 more
doaj   +1 more source

Delivery of Biomimetic Liposomes via Meningeal Lymphatic Vessels Route for Targeted Therapy of Parkinson's Disease. [PDF]

Research (Wash D C), 2023
Liu J, Gao D, Hu D, Lan S, Liu Y, Zheng H, Yuan Z, Sheng Z.   +7 more
europepmc   +1 more source

Lymphatic vessels in osteoarthritic human knees

, 2012
Objectives: The distribution and function of lymphatic vessels in normal and diseased human knees are understood incompletely. This study aimed to investigate whether lymphatic density is associated with clinical, histological or radiographic parameters ...
Verghese, P., Walsh, D. A., Mapp, P. I., Cook, G. J., Wilson, D., McWilliams, D. F., Ashraf, S.   +6 more
core   +1 more source