Results 121 to 130 of about 353,217 (149)

Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human

Annals of Neurology, 2020
ObjectiveAging is a major risk factor for numerous neurological disorders, and the mechanisms underlying brain aging remain elusive. Recent animal studies demonstrated a tight relationship between impairment of the glymphatic pathway, meningeal lymphatic vessels, and aging.
Ying Zhou, Jinsong Cai, Wenhua Zhang, Xiaoxian Gong, Shenqiang Yan, Kemeng Zhang, Zhongyu Luo, Jianzhong Sun, Quan Jiang, Min Lou   +9 more
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Complexity Analysis and u-net Based Segmentation of Meningeal Lymphatic Vessels

2020 54th Asilomar Conference on Signals, Systems, and Computers, 2020
This paper showcases a u-net based architecture for the automated segmentation images of meningeal lymphatic vessels. These lymphatic vessels surround the cerebral cortex and have been recently found to drain waste from the brain. Studies on mice have shown loss of memory and impairment in cognitive ability if the vessels’ draining capacity does not ...
Nazia Tabassum, Michael Ferguson, Jasmin Herz, Scott T. Acton   +3 more
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Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination [PDF]

Immunity
The precise neurophysiological changes prompted by meningeal lymphatic dysfunction remain unclear. Here, we showed that inducing meningeal lymphatic vessel ablation in adult mice led to gene expression changes in glial cells, followed by reductions in ...
Da Mesquita S, Jean-Leon Thomas
exaly   +2 more sources

Barenblatt-like approach to transport processes in meningeal lymphatic vessel’s dynamics

The European Physical Journal Plus, 2021
We propose a model, which describes the transfer of a marker inside the lymphatic microvessel by the lymph flow as a consequence of the vessel’s elastic deformation, which produces the pushing pressure jump. The resulting model is close to the equation of the nonlinear diffusion with a localized moving front solution.
Anastasia I. Lavrova, Eugene B. Postnikov   +1 more
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Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system

Nature Neuroscience, 2022
Recent studies have demonstrated that brain meningeal lymphatic vessels (MLVs) act as a drainage path directly into the cervical lymph nodes (CLNs) for macromolecules contained in the cerebrospinal fluid (CSF). However, the role of MLVs during CNS viral infection remains unexplored. Here, we found that infection with several neurotropic viruses in mice
Xiaojing Li, Linlin Qi, Dan Yang, ShuJie Hao, Fang Zhang, Xingguo Zhu, Yue Sun, Chen Chen, Jing Ye, Jing Yang, Ling Zhao, Daniel M. Altmann, Shengbo Cao, Hongyan Wang, Bin Wei   +14 more
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Image Analysis for Describing Meningeal Lymphatic Vessel Morphology

2020
Neuroscientists have recently discovered the existence of meningeal lymphatic vessels in the brain and have shown their importance in preventing cognitive decline. With age, lymphatic vessels narrow, poorly draining cerebrospinal and interstitial fluids, which leads to plaque accumulation, a hallmark of Alzheimer’s disease.
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Advances in Research on Meningeal Lymphatic Vessels in Central Nervous System Diseases

Journal of Craniofacial Surgery
Meningeal lymphatic vessels (mLVs), located around the dural sinuses, are considered significant participants in cerebrospinal fluid (CSF) circulation. Meningeal lymphatic vessels not only drain fluids and metabolic waste from the brain into deep cervical lymph nodes (dCLNs) but also transport immune cells from the brain to dCLNs, thus regulating the ...
Huimin, Shen, Bingrui, Zhu, Yajun, Qian, Jiancheng, Jin, Jiankuai, Zhou, Guotao, Peng, Jun, Mo   +6 more
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Meningeal Lymphatic Vessels Contribute to Microglia Activation and Behavioral Response to Peripheral Inflammation

2022
The recently discovered meningeal lymphatic system represents a potential point of access to the brain from the immune system that remains unexplored in the context of sickness behavior. Publications from our lab have established that meningeal lymphatic vessels facilitate solute clearance from the brain parenchyma and that these vessels deteriorate ...
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Abstract P346: Expansion of meningeal lymphatic vessels in DOCA-salt hypertension

Hypertension
The meningeal lymphatic system is critical for proper brain waste clearance and maintenance of the local meningeal neuroimmune niche. Meningeal lymphatic function is impaired during aging and neurodegenerative diseases and is associated with the development of cognitive impairment.
Melissa Sobanko, Monica Santisteban
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Evaluation of Glymphatic-Meningeal Lymphatic Vessels with delayed contrast enhanced vessel-wall MRI in Cerebral Infarction

ISMRM Annual Meeting
Motivation: To observe clearance pathways in patients with cerebral infarction. Goal(s): The goal of this study is to identify novel in vivo human findings regarding the clearance pathways in patients with cerebral infarction. Approach: 3D T1 DANTE SPACE imaging was performed 1-5 hours after intravenous injection of gadolinium-based contrast agent ...
Masaki Umehana, Yasutaka Fushimi, Sachi Okuchi, Sayo Otani, Akihiko Sakata, Takayuki Yamamoto, Satoshi Nakajima, Satoshi Ikeda, Shuichi Ito, Yongping Ma, Shin Morooka, John Grinstead, Sinyeob Ahn, Katsuhiko Mitsumoto, Yuji Nakamoto   +14 more
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