Results 81 to 90 of about 6,220 (169)

Analyzing the Feasibility of Surgical Approaches to Improve Cerebral Lymphatic Circulation in Alzheimer Disease

Guoji laonian yixue zazhi
Traditionally, it was believed that the human brain lacked lymphatic vessels. However, recent studies have progressively confirmed the existence of meningeal lymphatic vessels and the glymphatic system.
Zhao Yangguang, Li Xia, Fang Yuan, Zhang Yonghong, Ren Zhenhu   +4 more
doaj   +1 more source

Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes

Nature Communications, 2022
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral
Mehmet Sait Albayram, Garrett Smith, Fatih Tufan, Ibrahim Sacit Tuna, Mehmet Bostancıklıoğlu, Michael Zile, Onder Albayram   +6 more
doaj   +1 more source

Image_1_Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels.TIF

, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint (8294349), Zsombor Ocskay (8294352), Bálint András Deák (8294355), Petra Aradi (6647627), Zoltán Jakus (81532)   +4 more
core   +1 more source

Image_2_Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels.TIF

, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint (8294349), Zsombor Ocskay (8294352), Bálint András Deák (8294355), Petra Aradi (6647627), Zoltán Jakus (81532)   +4 more
core   +1 more source

Bundle structures inside the deep cervical lymphatic vessels of mice

Scientific Reports
The lymphatic system plays a crucial role in immune function and the removal of cellular waste. Recent studies have highlighted the presence of primo vessels (PVs) inside lymphatic vessels, distinct from conventional lymphatic tissues, yet their ...
Joonyoung Shin, Sungchul Kim
doaj   +1 more source

Circulatory pro‐CTSD binds brain endothelial LRP1 to trigger its lysosomal degradation leading to amyloid beta clearance deficit in Alzheimer's disease mice

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Clearance of cerebral Aβ was primarily mediated by the brain endothelial transporters including LRP1. The regulatory mechanism of LRP1 expression remained unclear. METHODS LRP1 in brain endothelial cells treated with pro‐CTSD were analyzed by western blot.
Zhi‐Jun Li, Zhao Yang, Dan Zhao, Yi‐Hua Qiu, Wen‐Yu Wan, Zeng‐Kang Huang, Li Tian, Rui‐Qun Qi, Hong‐Guang Liu, Yu‐Hua Chen, Dong‐Yu Min, Xiao‐Qian Xu, Wei‐Dong Zhao   +12 more
wiley   +1 more source

Optical coherent tomography and fluorescent microscopy for the study of meningeal lymphatic systems

, 2018
The development of novel technologies for the imaging of meningeal lymphatic vessels is one of the amazing trends of biophotonics thanks to discovery of brain lymphatics over several years ago.
Abdurashitov, Arkady S., Shareef, Ali Ismat, V. Tuchin, Sindeeva, Olga A., Semyachkina-Glushkovskaya, Oxana V., M. Ulanova, M. Dvoryatkina, Oxana V. Semyachkina-Glushkovskaya, Ulanova, Mariya V., Karavaev, A., A. Pavlov, O. Sindeeva, I. Agranovich, E. Saranceva, A. Shirokov, Namykin, Anton A., Khorovodov, Alexander P., Saranceva, Elena, Shushunova, Natalia A., A. Abdurashitov, A. Namykin, A. Karavaev, Pavlov, Alexey, A. Khorovodov, Agranovich, Ilana, Bodrova, Anastasia A., I. Fedosov, Fedosov, Ivan V., N. Shushunova, Sagatova, Madina M., Dvoryatkina, M., M. Sagatova, Ali Esmat Shareef, Tuchin, Valery V., Shirokov, Alexander, A. Bodrova   +35 more
core   +1 more source

Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework

, 2021
The potential existence and roles of the meningeal lymphatic system in normal and pathological brain function have been a long-standing enigma. Recent evidence suggests that meningeal lymphatic vessels are present in both the mouse and human brain; in ...
Mentis, A.-F.A., Dardiotis, E., Mentis A.-F.A., Dardiotis E., Chrousos G.P., Chrousos, G.P.   +3 more
core   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Anatomic evidence shows that lymphatic drainage exists in the pituitary to loop the cerebral lymphatic circulation [PDF]

, 2020
Respiratory infections can result in intracranial infections and unknown neurological symptoms. The central nervous system lacks classical meningeal lymphatic (circulation) drainage, and the exact underlying mechanisms of how immune cells from the ...
Elham, Elzat, Chen, Tao, Wumaier, Reziya, Zhong, Nanshan, Wang, Chengji, Luo, Xiangying   +5 more
core   +1 more source