Results 81 to 90 of about 34,570 (162)

Analysis of norepinephrine-regulated cerebral lymphatic drainage by the second near-infrared region in vivo imaging

APL Photonics
The cerebral lymphatic drainage plays an important role in the occurrence and development of central nervous system diseases. Recent studies have shown that cerebral lymphatic drainage is regulated by circadian rhythm and anesthesia state; however, the ...
Xi Li, Tianhao Yang, Zhongyang Zhang, Shengnan Wu, Zhen Yuan, Feifan Zhou   +5 more
doaj   +1 more source

dab2 is required for the scavenging function of lymphatic endothelial cells in the zebrafish meninges

Scientific Reports
To date it is only partially understood how the brain is cleared of waste products resulting from its high metabolic activity, although this process has important implications for the development and progression of neurodegenerative diseases.
Katharina Uphoff, Irina Suárez, Andreas van Impel, Stefan Schulte-Merker   +3 more
doaj   +1 more source

Therapeutic approaches to CNS diseases via the meningeal lymphatic and glymphatic system: prospects and challenges

Frontiers in Cell and Developmental Biology
The brain has traditionally been considered an “immune-privileged” organ lacking a lymphatic system. However, recent studies have challenged this view by identifying the presence of the glymphatic system and meningeal lymphatic vessels (MLVs).
Rui Zhang, Jiuhong Li, Xueying Li, Si Zhang   +3 more
doaj   +1 more source

Spatiotemporal dynamic changes of meningeal microenvironment influence meningeal lymphatic function following subarachnoid hemorrhage: from inflammatory response to tissue remodeling

Journal of Neuroinflammation
Background Meningeal lymphatic vessels (mLVs) play a critical role in clearing erythrocytes from the subarachnoid space and immune cells from the brain parenchyma following subarachnoid hemorrhage (SAH). However, the drainage function of mLVs is impaired
Bingrui Zhu, Changming Liu, Ming Luo, Jiarui Chen, Sixuan Tian, Tiantong Zhan, Yibo Liu, Haocheng Zhang, Zhen Wang, Jianmin Zhang, Yuanjian Fang, Sheng Chen, Xiaoyu Wang   +12 more
doaj   +1 more source

Complex Non-sinus-associated Pachymeningeal Lymphatic Structures: Interrelationship With Blood Microvasculature

Frontiers in Physiology, 2019
The contribution of cranial dura mater vascular networks, as means for maintaining brain fluid movement and balance, and as the source of significant initiators and/or contributors to neurological disorders, has been overlooked. These networks consist of
Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Olga V. Glinskii, Virginia H. Huxley, Virginia H. Huxley, Virginia H. Huxley, Leike Xie, Filiz Bunyak, Kannappan Palaniappan, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky, Vladislav V. Glinsky   +13 more
doaj   +1 more source

Piezo1 regulates meningeal lymphatic vessel drainage and alleviates excessive CSF accumulation

Nature Neuroscience
Abstract Piezo1 regulates multiple aspects of the vascular system by converting mechanical signals generated by fluid flow into biological processes. Here, we find that Piezo1 is necessary for the proper development and function of meningeal lymphatic vessels and that activating Piezo1 through transgenic overexpression or treatment ...
Dongwon Choi, Eunkyung Park, Joshua Choi, Renhao Lu, Jin Suh Yu, Chiyoon Kim, Luping Zhao, James Yu, Brandon Nakashima, Sunju Lee, Dhruv Singhal, Joshua P. Scallan, Bin Zhou, Chester J. Koh, Esak Lee, Young-Kwon Hong   +15 more
openaire   +2 more sources

Dural Macrophages in The Regulation of Meningeal Lymphatic Vessel Structure and Brain Lymph Drainage

, 2023
Meningeal lymphatic vessels (mLVs) are the primary route for cerebrospinal fluid (CSF) outflow from the brain. Importantly, dysfunction of mLVs in mice has been shown to increase toxic protein accumulation, resulting in a decline in neurocognitive processing.
openaire   +2 more sources

Incorporating meningeal immunity into vaccine development

Nature Communications
Meningeal immunity, a less-studied aspect of neuroimmune interactions, has recently come under the spotlight owing to the characterization of meningeal lymphatic vessels draining of the central nervous system (CNS).
Manisha Menon, Colin N. Haile, David J. Dowling   +2 more
doaj   +1 more source

Cerebral venous blood flow regulates intracerebral pressure and brain clearance via meningeal lymphatic vessels.

Nature Neuroscience
Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure and dural venous sinus stenoses, which can be relieved by venous stenting.
Marie-Renee El Kamouh, Myriam Spajer, Ruchith Singhabahu, Anne-Laure Joly Marolany, Kurt A Sailor, Laura Mouton, D. Doukhi, Sunil Koundal, Tanner Metcalfe, D. Langui, A. Grine, Kevin Boyé, Felipe Saceanu Leser, J. Ninnemann, Joshua Gottschalk, Cyrus Sadeghi, Han Xu, L. Boisserand, D. Akbar, Jérôme Van Wassenhove, Anthony Ruze, A. Nasri, Marie-Charlotte Bourrienne, Elora Buscher, Young-Kwon Hong, Mikael Mazighi, P. Lledo, Helene Benveniste, Mathieu Santin, Anne Eichmann, Stéphane Lehericy, J. Thomas, Stéphanie Lenck   +32 more
semanticscholar   +1 more source

Age-related development of meningeal lymphatic vessels in children assessed by 3D T2 FLAIR MRI

Scientific Reports
Meningeal lymphatic vessels (mLVs) are closely associated with the development of numerous neurological diseases. While age has been identified as a crucial factor that influences the meningeal lymphatics, their developmental characteristics in children ...
Jianbin Ying, Yanying Rao, Xuanjie Chen, Fan Chen, Taotao Zhang, Jun Li, Shousen Wang, Jinrun Lin, Yuyan He, Jiarong Chen, Liping Zeng, Xiaoyan Wu, Yu Liu, Qingshuang Zhao, Junjie Jing   +14 more
semanticscholar   +1 more source