Results 81 to 90 of about 373,387 (179)

Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson’s disease

, 2021
Animal studies implicate meningeal lymphatic dysfunction in the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease (PD). However, there is no direct evidence in humans to support this role1–5. In this study, we
Ding, Xue Bing, Wang, Xin Xin, Liu, Han, Qin, Chi, Wang, Jiu Qi, Wang, Wei, Xia, Dan Hao, Ma, Ming Ming, Fu, Yu, Wu, Erxi, Teng, Jun Fang, Li, Jia Yi, Cao, Qin Chen, Tang, Bei Sha, Wang, Xue Jing, Chen, Yong Kang, Xiang, Zhi, Tian, Hai Yan, Zhang, Zhong Xian, Li, Jia Yi,, Xia, Dan Hao,, Zhang, Zhong Xian,, Wang, Jiu Qi,, Teng, Jun Fang,, Ma, Ming Ming,, Liu, Han,, Xiang, Zhi,, Wu, Erxi,, Wang, Xue Jing,, Wang, Xin Xin,, Cao, Qin Chen,, Chen, Yong Kang,, Ding, Xue Bing,, Fu, Yu,, Qin, Chi,, Tian, Hai Yan,, Lund University., Tang, Bei Sha,, Erxi Wu, Bei-Sha Tang, Chi Qin, Jun-Fang Teng, Wei Wang, Zhong-Xian Zhang, Jia-Yi Li, Han Liu, Hai-Yan Tian, Qin-Chen Cao, Jiu-Qi Wang, Zhi Xiang, Yu Fu, Xue-Bing Ding, Xue-Jing Wang, Xin-Xin Wang, Dan-Hao Xia, Ming-Ming Ma, Yong-Kang Chen   +56 more
core   +1 more source

Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation, neurodegeneration, and cognitive decline.
James D. LeFevre, Yukti Vyas, Angela L. Jefferson   +2 more
wiley   +1 more source

DTI‐ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi‐Modal MRI

Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.
In a 100‐patient memory‐clinic cohort, DTI‐ALPS was evaluated along with diffusion and microstructural metrics. DTI‐ALPS correlated strongly with mode of anisotropy and orientation dispersion index, and moderately with T1/FLAIR ratio and diamagnetic susceptibility, indicating that DTI‐ALPS mainly reflects white‐matter diffusion complexity rather than ...
Luca Sacchi, Giovanni Farruggio, Giorgio Bocca, Tiziana Carandini, Milena De Riz, Laura Ghezzi, Manuela Pintus, Anna Pietroboni, Giacomo Boffa, Elisa Scola, Fabio Triulzi, Marco Bozzali, Daniela Galimberti, Mara Cercignani, Andrea Arighi   +14 more
wiley   +1 more source

Harnessing Natural Killer Cells: From Neuroimmunology to Novel Therapies for Central Nervous System Diseases

MedComm, Volume 7, Issue 10, October 2026.
This review delineates the multifaceted roles of natural killer (NK) cells in the central nervous system, spanning direct cytolysis, immunoregulation, and crosstalk with the brain microenvironment. We evaluate the translational potential and challenges of NK cell immunotherapies for a spectrum of neurological conditions.
Kaihang Deng, Wai Po Chong
wiley   +1 more source

The meningeal lymphatic system: a route for HIV brain migration? [PDF]

, 2016
Two innovative studies recently identified functional lymphatic structures in the meninges that may influence the development of HIV-associated neurological disorders (HAND).
Rose, Rebecca, Nolan, David J, Stoddart, Cheryl A, Ndhlovu, Lishomwa C, Salemi, Marco, McGrath, Michael S, Lamers, Susanna L, Maidji, Ekaterina   +7 more
core   +1 more source

Analyzing the Feasibility of Surgical Approaches to Improve Cerebral Lymphatic Circulation in Alzheimer Disease

Guoji laonian yixue zazhi
Traditionally, it was believed that the human brain lacked lymphatic vessels. However, recent studies have progressively confirmed the existence of meningeal lymphatic vessels and the glymphatic system.
Zhao Yangguang, Li Xia, Fang Yuan, Zhang Yonghong, Ren Zhenhu   +4 more
doaj   +1 more source

Integrating DCE‐MRI‐Based Dural Drainage Function Indicators into Machine Learning Models for Improved Intracranial Tumor Prognosis

MedComm, Volume 7, Issue 10, October 2026.
We integrated DCE‐MRI‐based dural drainage function indicators (DDFIs) that reflect meningeal lymphatic vessels (mLVs) function into XGBoost models to predict the prognosis of intracranial malignant tumors. In a 2.5‐year follow‐up cohort of 100 patients, DDFIs remarkably improved the model's predictive performance, with a more significant enhancement ...
Lusen Ran, Wenxi Luo, Luyun You, Wenjie Wei, Yuqin He, Shabei Xu, Jiayu Zhu, Fan Long, Xiaopeng Song, Guangyuan Hu, Xianglin Yuan, Wei Wang, Feng Lu, Minghuan Wang, YingYing Wu   +14 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Bundle structures inside the deep cervical lymphatic vessels of mice

Scientific Reports
The lymphatic system plays a crucial role in immune function and the removal of cellular waste. Recent studies have highlighted the presence of primo vessels (PVs) inside lymphatic vessels, distinct from conventional lymphatic tissues, yet their ...
Joonyoung Shin, Sungchul Kim
doaj   +1 more source

Bruton's Tyrosine Kinase Inhibitors: Mechanisms, Efficacy, Toxicities and Applications for the Treatment of Human Diseases

MedComm, Volume 7, Issue 10, October 2026.
BTK inhibitors suppress malignant B‐cell signaling while simultaneously reshaping immune regulation through effects on T cells and the tumor microenvironment. These mechanisms support combination immunotherapy strategies and also underlie the expanding application of BTK inhibitors in solid tumors, autoimmune and inflammatory diseases.
Miao Sun, Dengju Li, Jia Wei
wiley   +1 more source