Results 11 to 20 of about 3,212 (171)
Meningeal lymphatics can influence stroke outcome. [PDF]
J Exp MedMeningeal lymphatics are conduits for cerebrospinal fluid drainage to lymphatics and lymph nodes in the neck. In this issue of JEM, Boisserand et al. (https://doi.org/10.1084/jem.20221983) provide evidence that expansion of meningeal lymphatics protects ...
Koh GY, McDonald DM.
europepmc +7 more sources
Meningeal lymphatics as a therapeutic target for neurodegenerative disorders. [PDF]
Transl NeurodegenerAdvancements in visualization methods have brought the meningeal lymphatic system (MLS) into the spotlight. The meningeal lymphatic vessels (mLVs) play a vital role in draining cerebrospinal fluid and immune cells, acting as a central hub for immune ...
Feng Y +6 more
europepmc +4 more sources
Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow [PDF]
Journal of NeuroImmune Pharmacology, 2018 Functional meningeal lymphatic system plays a crucial role in outflow of cerebrospinal fluid. Metabolites and neurotoxins in the cerebrospinal fluid may be excreted via this system and accumulate in the cervical lymph nodes. In this letter, we highlighted the role of functional meningeal lymphatics and cerebrospinal fluid outflow.
Rajnish S Dave +2 more
exaly +6 more sources
Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. [PDF]
J Clin Invest, 2017 Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism.
Louveau A +5 more
europepmc +7 more sources
Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery
iScienceSummary: The anatomical basis of cerebrospinal and interstitial fluid clearance along the human ventral meninges remains poorly defined. Here, we present the in vivo and ex vivo evidence of a distinct CSF-ISF drainage compartment surrounding the middle ...
Mehmet Albayram +13 more
doaj +5 more sources
Glymphatics and meningeal lymphatics unlock the brain-immune code [PDF]
ImmunityThe central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind the blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology.
Min Woo Kim, Jonathan Kipnis
exaly +7 more sources
Meningeal Lymphatics in Central Nervous System Diseases [PDF]
Annual Review of NeuroscienceSince its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment ...
Jonathan Kipnis
exaly +4 more sources
Meningeal lymphatics "drain" brain tumors. [PDF]
Cell Res, 2020 Kanamori M, Kipnis J.
europepmc +5 more sources
Meningeal lymphatics-microglia axis regulates synaptic physiology [PDF]
CellMeningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral changes, but the neural mechanisms underlying these changes have remained elusive.
Siling Du +2 more
exaly +4 more sources
Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases [PDF]
Frontiers in Cellular Neuroscience, 2021 The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu +3 more
doaj +2 more sources