Glymphatics and meningeal lymphatics unlock the brain-immune code [PDF]
ImmunityThe central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind the blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology.
Jonathan Kipnis
exaly +7 more sources
Meningeal Lymphatics in Central Nervous System Diseases [PDF]
Annual Review of NeuroscienceSince its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment ...
Jonathan Kipnis
exaly +4 more sources
Meningeal lymphatics-microglia axis regulates synaptic physiology [PDF]
CellMeningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral changes, but the neural mechanisms underlying these changes have remained elusive.
Marco Colonna +2 more
exaly +4 more sources
Functional Meningeal Lymphatics and Cerebrospinal Fluid Outflow [PDF]
Journal of NeuroImmune Pharmacology, 2018 Functional meningeal lymphatic system plays a crucial role in outflow of cerebrospinal fluid. Metabolites and neurotoxins in the cerebrospinal fluid may be excreted via this system and accumulate in the cervical lymph nodes. In this letter, we highlighted the role of functional meningeal lymphatics and cerebrospinal fluid outflow.
Pooja Jain +2 more
exaly +5 more sources
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease [PDF]
Nature, 2018 Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks lymphatic vasculature and waste products are removed partly through a paravascular route.
Christopher Overall +2 more
exaly +5 more sources
Meningeal Lymphatics Drives Macrophage Clearance via CCL2-CCR2 Axis After Cerebral Ischemia [PDF]
Current Issues in Molecular BiologyThe mechanisms underlying meningeal lymphatic vessel (mLV)-mediated immune cell clearance after stroke remain unclear. Using a mouse middle cerebral artery occlusion model, we performed single-cell RNA sequencing to analyze post-ischemic meningeal ...
Jing Wang +3 more
doaj +2 more sources
Mechanisms of phototherapy of Alzheimer’s disease during sleep and wakefulness: the role of the meningeal lymphatics [PDF]
Frontiers of Optoelectronics, 2023 With the increase in the aging population, the global number of people with Alzheimer’s disease (AD) progressively increased worldwide. The situation is aggravated by the fact that there is no the effective pharmacological therapy of AD ...
Semyachkina-Glushkovskaya Oxana +16 more
doaj +2 more sources
Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective [PDF]
Neuroscience Insights, 2019 The recent discovery of lymphatic vessels in the meningeal layers calls into question the known mechanisms of fluid and macromolecule homeostasis and immunoregulation within the central nervous system.
Korri S Hershenhouse +3 more
doaj +2 more sources
Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice [PDF]
Nature CommunicationsMeningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Miao Wang +7 more
doaj +2 more sources
Role of the Meningeal Lymphatics in Stroke. [PDF]
Stroke, 2023 Perla M +3 more
europepmc +4 more sources