Results 11 to 20 of about 3,252 (154)

Glymphatics and meningeal lymphatics unlock the brain-immune code [PDF]

Immunity
The central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind the blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology.
Jonathan Kipnis
exaly   +7 more sources

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease [PDF]

Nature, 2018
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks lymphatic vasculature and waste products are removed partly through a paravascular route.
Christopher M Overall, Robert Cornelison, Sandro Da Mesquita   +2 more
exaly   +5 more sources

Meningeal lymphatics-microglia axis regulates synaptic physiology [PDF]

Cell
Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions. Previous studies have demonstrated that dysfunctional meningeal lymphatics evoke behavioral changes, but the neural mechanisms underlying these changes have remained elusive.
Marco Colonna, Zachary Papadopoulos, Jasmin Herz   +2 more
exaly   +4 more sources

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Yujie Chen, Hua Feng, Yin Niu
exaly   +2 more sources

Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective [PDF]

Neuroscience Insights, 2019
The recent discovery of lymphatic vessels in the meningeal layers calls into question the known mechanisms of fluid and macromolecule homeostasis and immunoregulation within the central nervous system.
Korri S Hershenhouse, Orr Shauly, Daniel J Gould, Ketan M Patel   +3 more
doaj   +2 more sources

Impaired Meningeal Lymphatics and Glymphatic Pathway in Patients with White Matter Hyperintensity [PDF]

Advanced Science
White matter hyperintensity (WMH) represents a critical global medical concern linked to cognitive decline and dementia, yet its underlying mechanisms remain poorly understood.
Ying Zhou, Rui Xue, Yifei Li, Wang Ran, Yuping Chen, Zhongyu Luo, Kemeng Zhang, Ruoxia Zhang, Junjun Wang, Mengmeng Fang, Cong Chen, Min Lou   +11 more
doaj   +2 more sources

Role of the Meningeal Lymphatics in Stroke. [PDF]

Stroke, 2023
Perla M, Caretti V, Moro MA, McCullough LD.   +3 more
europepmc   +4 more sources

Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice [PDF]

Nature Communications
Meningeal lymphatic vessels (mLVs) have been shown to be involved in amyloid beta (Aβ) clearance, which is considered as a potential therapeutic target for Alzheimer’s disease (AD).
Miao Wang, Congcong Yan, Xi Li, Tianhao Yang, Shengnan Wu, Qian Liu, Qingming Luo, Feifan Zhou   +7 more
doaj   +2 more sources

Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery

iScience
Summary: The anatomical basis of cerebrospinal and interstitial fluid clearance along the human ventral meninges remains poorly defined. Here, we present the in vivo and ex vivo evidence of a distinct CSF-ISF drainage compartment surrounding the middle ...
Mehmet Albayram, Sutton B. Richmond, Kaan Yagmurlu, Ibrahim S. Tuna, Eda Karakaya, Hiranmayi Ravichandran, Fatih Tufan, Emal Lesha, Melike Mut, Filiz Bunyak, Yashar.S. Kalani, Adviye Ergul, Rachael D. Seidler, Onder Albayram   +13 more
doaj   +4 more sources

Meningeal lymphatics "drain" brain tumors. [PDF]

Cell Res, 2020
Kanamori M, Kipnis J.
europepmc   +4 more sources