Results 21 to 30 of about 3,252 (154)

Meningeal lymphatics in aging and Alzheimer's disease. [PDF]

Ann Transl Med, 2019
Recent research from the Kipnis laboratory (1-3) has highlighted the significance of meningeal lymphatics, which were originally identified in the dura mater of rat (4). These investigators underscored the crucial role of the meningeal lymphatics in brain immune surveillance and the clearance of metabolic wastes. They have also mapped out the path and
Jaffe RJ, Dave RS, Byrareddy SN.
europepmc   +3 more sources

Meningeal lymphatics prime tumor immunity in glioblastoma. [PDF]

Cancer Cell, 2021
The notion of the brain as an immune-privileged organ has been challenged by the discovery of functional lymphatic vessels in the meninges of the dorsal and basal skull. A study published in Nature in 2020 shows that meningeal lymphatics play an important role in the sensing of brain tumor antigens.
Graham MS, Mellinghoff IK.
europepmc   +3 more sources

CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges

Frontiers in Pharmacology, 2021
A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves, Nickoleta Delivanoglou, Sandro Da Mesquita   +2 more
doaj   +1 more source

New insight into DAVF pathology—Clues from meningeal immunity

Frontiers in Immunology, 2022
In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape.
Tianqi Tu, Tianqi Tu, Zhenghong Peng, Zihao Song, Zihao Song, Yongjie Ma, Yongjie Ma, Hongqi Zhang, Hongqi Zhang   +8 more
doaj   +1 more source

Meningeal Lymphatics in Central Nervous System Diseases. [PDF]

Annu Rev Neurosci
Since its recent discovery, the meningeal lymphatic system has reshaped our understanding of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking, and immune privilege. Meningeal lymphatics have also been demonstrated to functionally modify the outcome of neurological disorders and their responses to treatment ...
Salvador AFM, Abduljawad N, Kipnis J.
europepmc   +3 more sources

Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases

Frontiers in Cellular Neuroscience, 2021
The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu, Collin Laaker, Matyas Sandor, Zsuzsanna Fabry   +3 more
doaj   +1 more source

Immune cells as messengers from the CNS to the periphery: the role of the meningeal lymphatic system in immune cell migration from the CNS

Frontiers in Immunology, 2023
In recent decades there has been a large focus on understanding the mechanisms of peripheral immune cell infiltration into the central nervous system (CNS) in neuroinflammatory diseases.
Collin Laaker, Cameron Baenen, Kristóf G. Kovács, Matyas Sandor, Zsuzsanna Fabry   +4 more
doaj   +1 more source

Meningeal lymphatics can influence stroke outcome. [PDF]

J Exp Med
Meningeal lymphatics are conduits for cerebrospinal fluid drainage to lymphatics and lymph nodes in the neck. In this issue of JEM, Boisserand et al. (https://doi.org/10.1084/jem.20221983) provide evidence that expansion of meningeal lymphatics protects against ischemic stroke.
Koh GY, McDonald DM.
europepmc   +5 more sources

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels

Frontiers in Immunology, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint, László Bálint, Zsombor Ocskay, Zsombor Ocskay, Bálint András Deák, Bálint András Deák, Petra Aradi, Petra Aradi, Zoltán Jakus, Zoltán Jakus   +9 more
doaj   +1 more source

Abstract 1122‐000183: Assessing Meningeal Lymphatic MRI Biomarkers in Acute Large Vessel Occlusion Stroke Treated with Thrombectomy

Stroke: Vascular and Interventional Neurology, 2021
Introduction: Until recently, there was very little known about the brain’s waste removal system. Unlike the peripheral organ systems, the CNS lacked a clearly defined lymphatic vasculature and waste clearance mechanism.
Richard Pham, Rano Chatterjee
doaj   +1 more source