Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery
iScienceSummary: The anatomical basis of cerebrospinal and interstitial fluid clearance along the human ventral meninges remains poorly defined. Here, we present the in vivo and ex vivo evidence of a distinct CSF-ISF drainage compartment surrounding the middle ...
Mehmet Albayram +13 more
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Visualising and semi-quantitatively measuring brain fluid pathways, including meningeal lymphatics, in humans using widely available MRI techniques [PDF]
Journal of Cerebral Blood Flow and Metabolism, 2023 Michael Thrippleton +2 more
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Meningeal lymphatics "drain" brain tumors. [PDF]
Cell Res, 2020 Kanamori M, Kipnis J.
europepmc +4 more sources
New integrated three-interface conceptual model for clearance and immune surveillance in the human CNS [PDF]
Frontiers in Cell and Developmental BiologyThe central nervous system (CNS) lacks a classical lymphatic system and instead relies on cerebrospinal fluid (CSF) circulation for metabolic waste removal and for defense/immune surveillance. Recent research has consolidated the concept of an integrated
José García-Cosamalón +6 more
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The Space between the Pial Sheath and the Cortical Venous Wall May Connect to the Meningeal Lymphatics [PDF]
Magnetic Resonance in Medical Sciences, 2020 Michihiko Sone +2 more
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Meningeal lymphatics prime tumor immunity in glioblastoma. [PDF]
Cancer Cell, 2021 The notion of the brain as an immune-privileged organ has been challenged by the discovery of functional lymphatic vessels in the meninges of the dorsal and basal skull. A study published in Nature in 2020 shows that meningeal lymphatics play an important role in the sensing of brain tumor antigens.
Graham MS, Mellinghoff IK.
europepmc +3 more sources
Meningeal lymphatics in aging and Alzheimer's disease. [PDF]
Ann Transl Med, 2019 Recent research from the Kipnis laboratory (1-3) has highlighted the significance of meningeal lymphatics, which were originally identified in the dura mater of rat (4). These investigators underscored the crucial role of the meningeal lymphatics in brain immune surveillance and the clearance of metabolic wastes. They have also mapped out the path and
Jaffe RJ, Dave RS, Byrareddy SN.
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CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
Frontiers in Pharmacology, 2021 A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
Sofia Pereira das Neves +2 more
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New insight into DAVF pathology—Clues from meningeal immunity
Frontiers in Immunology, 2022 In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape.
Tianqi Tu +8 more
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Neuroinflammation-Driven Lymphangiogenesis in CNS Diseases
Frontiers in Cellular Neuroscience, 2021 The central nervous system (CNS) undergoes immunosurveillance despite the lack of conventional antigen presenting cells and lymphatic vessels in the CNS parenchyma. Additionally, the CNS is bathed in a cerebrospinal fluid (CSF).
Martin Hsu +3 more
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