Results 21 to 30 of about 3,212 (171)

Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy. [PDF]

Nature, 2021
Alzheimer's disease (AD) is the most prevalent cause of dementia1. Although there is no effective treatment for AD, passive immunotherapy with monoclonal antibodies against amyloid beta (Aβ) is a promising therapeutic strategy2,3.
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, Wall M, Jiang H, Kodira CD, de Lima KA, Herz J, Louveau A, Goldman DH, Salvador AF, Onengut-Gumuscu S, Farber E, Dabhi N, Kennedy T, Milam MG, Baker W, Smirnov I, Rich SS, Dominantly Inherited Alzheimer Network, Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J.   +30 more
europepmc   +2 more sources

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease [PDF]

Nature, 2018
Ageing is a major risk factor for many neurological pathologies, but its mechanisms remain unclear. Unlike other tissues, the parenchyma of the central nervous system (CNS) lacks lymphatic vasculature and waste products are removed partly through a paravascular route.
Sandro Da Mesquita, Antoine Louveau, Igor Smirnov   +2 more
exaly   +5 more sources

Abstract 1122‐000183: Assessing Meningeal Lymphatic MRI Biomarkers in Acute Large Vessel Occlusion Stroke Treated with Thrombectomy

Stroke: Vascular and Interventional Neurology, 2021
Introduction: Until recently, there was very little known about the brain’s waste removal system. Unlike the peripheral organ systems, the CNS lacked a clearly defined lymphatic vasculature and waste clearance mechanism.
Richard Pham, Rano Chatterjee
doaj   +2 more sources

Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo. [PDF]

Commun Biol
Systemic chemotherapy often affects cells beyond the tumor, raising concerns about their impact on peripheral tissues, including the central nervous system (CNS).
Roberts LM, Hammel JH, Jin P, Cunningham JJ, Schumaecker S, Davis S, Azar F, Feng TA, Wang M, Rutkowski M, Munson J.   +10 more
europepmc   +2 more sources

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
doaj   +2 more sources

Meningeal Lymphatics Drives Macrophage Clearance via CCL2-CCR2 Axis After Cerebral Ischemia. [PDF]

Curr Issues Mol Biol
The mechanisms underlying meningeal lymphatic vessel (mLV)-mediated immune cell clearance after stroke remain unclear. Using a mouse middle cerebral artery occlusion model, we performed single-cell RNA sequencing to analyze post-ischemic meningeal ...
Wang J, Lei Y, Yang Y, Wang J.
europepmc   +2 more sources

Assessment of Meningeal Lymphatics in the Parasagittal Dural Space: A Prospective Feasibility Study Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging. [PDF]

Korean J Radiol, 2023
Objective: Meningeal lymphatic vessels are predominantly located in the parasagittal dural space (PSD); these vessels drain interstitial fluids out of the brain and contribute to the glymphatic system.
Joo B, Park M, Ahn SJ, Suh SH.
europepmc   +2 more sources

The Glymphatic System and Meningeal Lymphatics: Current Understandings and Future Perspectives. [PDF]

MedComm (2020)
The central nervous system (CNS) maintains homeostasis and immune surveillance through a recently defined brain‐wide clearance network: the glymphatic–lymphatic axis. This system couples the intramural glymphatic pathway, responsible for convective fluid
Sun H, Fan H, Zhou Y, Zhu H, Chen Y, Zhang R, Wang K, Pan Y, Zhang A.   +8 more
europepmc   +2 more sources

Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework. [PDF]

Mol Psychiatry, 2021
The potential existence and roles of the meningeal lymphatic system in normal and pathological brain function have been a long-standing enigma. Recent evidence suggests that meningeal lymphatic vessels are present in both the mouse and human brain; in ...
Mentis AA, Dardiotis E, Chrousos GP.
europepmc   +2 more sources

Impaired meningeal lymphatic vessel development worsens stroke outcome

Journal of Cerebral Blood Flow and Metabolism, 2020
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3 ...
Katherine Poinsatte, Kielen R Zuurbier, Erik J Plautz   +2 more
exaly   +3 more sources