Results 41 to 50 of about 3,212 (171)

Lymph Flow Induces the Postnatal Formation of Mature and Functional Meningeal Lymphatic Vessels

Frontiers in Immunology, 2020
Recently, the presence of lymphatics has been demonstrated and characterized in the dura mater, which is in contrast to the well-accepted view indicating the lack of a classical lymphatic drainage system of the central nervous system (CNS). Moreover, the
László Bálint, László Bálint, Zsombor Ocskay, Zsombor Ocskay, Bálint András Deák, Bálint András Deák, Petra Aradi, Petra Aradi, Zoltán Jakus, Zoltán Jakus   +9 more
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Development and plasticity of meningeal lymphatic vessels [PDF]

Journal of Experimental Medicine, 2017
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance. We show here that meningeal LVs develop postnatally, appearing first around the foramina in the basal parts of the skull and spinal canal, sprouting along
Aspelund Aleksanteri, Nurmi Harri, Alitalo Kari, Saarma Mart, Voutilainen Merja H., Airavaara Mikko, Antila Salli, Fang Shentong, Karaman Sinem, Li Zhilin, Aspelund Aleksanteri, Nurmi Harri, Alitalo Kari, Saarma Mart, Voutilainen Merja H., Airavaara Mikko, Antila Salli, Fang Shentong, Karaman Sinem, Li Zhilin   +19 more
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The cervical lymph node contributes to peripheral inflammation related to Parkinson’s disease

Journal of Neuroinflammation, 2023
Background Peripheral inflammation is an important feature of Parkinson’s disease (PD). However, if and how CNS pathology is involved in the peripheral inflammation in PD remains to be fully investigated.
Zongran Liu, Yang Huang, Xuejing Wang, Jia-Yi Li, Can Zhang, Ying Yang, Jing Zhang   +6 more
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CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature [PDF]

Nature Neuroscience, 2018
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link between the CNS and peripheral ...
Antoine Louveau, Jasmin Herz, Maria Nordheim Alme, Andrea Francesca Salvador, Michael Q. Dong, Kenneth E. Viar, S. Grace Herod, James Knopp, Joshua C. Setliff, Alexander L. Lupi, Sandro Da Mesquita, Elizabeth L. Frost, Alban Gaultier, Tajie H. Harris, Rui Cao, Song Hu, John R. Lukens, Igor Smirnov, Christopher C. Overall, Guillermo Oliver, Jonathan Kipnis   +20 more
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Charting the meningeal lymphatic network

Journal of Experimental Medicine, 2022
A genuine network of lymphatic vessels can be found in the dural layer of the meninges that ensheathe the brain and spinal cord of mammalians. In this issue, Jacob et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220035) employ light sheet fluorescence imaging of intact mouse heads to provide a more comprehensive chart of the meningeal lymphatic
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Postnatal development of lymphatic vasculature in the brain meninges [PDF]

Developmental Dynamics, 2018
Background: Traditionally, the central nervous system (CNS) has been viewed as an immune‐privileged environment with no lymphatic vessels. This view was partially overturned by the discovery of lymphatic vessels in the dural membrane that surrounds the brain, in contact with the interior surface of the skull.
Rebecca M. Izen, Tomoko Yamazaki, Yoko Nishinaka‐Arai, Young‐Kwon Hong, Yoh‐Suke Mukouyama   +4 more
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Photobiomodulation of lymphatic drainage and clearance: perspective strategy for augmentation of meningeal lymphatic functions [PDF]

Biomedical Optics Express, 2020
There is a hypothesis that augmentation of the drainage and clearing function of the meningeal lymphatic vessels (MLVs) might be a promising therapeutic target for preventing neurological diseases. Here we investigate mechanisms of photobiomodulation (PBM, 1267 nm) of lymphatic drainage and clearance.
Oxana Semyachkina-Glushkovskaya, Arkady Abdurashitov, Alexander Dubrovsky, Maria Klimova, Ilana Agranovich, Andrey Terskov, Alexander Shirokov, Valeria Vinnik, Anna Kuzmina, Nikita Lezhnev, Inna Blokhina, Anastassia Shnitenkova, Valery Tuchin, Edik Rafailov, Jurgen Kurths   +14 more
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The growth and expansion of meningeal lymphatic networks are affected in craniosynostosis [PDF]

Development, 2021
ABSTRACT Skull malformations are associated with vascular anomalies that can impair fluid balance in the central nervous system. We previously reported that humans with craniosynostosis and mutations in TWIST1 have dural venous sinus malformations. It is still unknown whether meningeal lymphatic networks, which are patterned alongside
Phillip S. Ang, Matt J. Matrongolo, Max A. Tischfield   +2 more
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The Meningeal Lymphatic System: A New Player in Neurophysiology [PDF]

Neuron, 2018
The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of particular relevance is its participation in diseases associated with protein accumulation and aggregation in the brain, such as Alzheimer's disease (AD).
Sandro, Da Mesquita, Zhongxiao, Fu, Jonathan, Kipnis   +2 more
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The role of the meningeal lymphatic system in local meningeal inflammation and trigeminal nociception

Scientific Reports, 2022
AbstractA system of lymphatic vessels has been recently characterized in the meninges, with a postulated role in ‘cleaning’ the brain via cerebral fluid drainage. As meninges are the origin site of migraine pain, we hypothesized that malfunctioning of the lymphatic system should affect the local trigeminal nociception.
Mikhailov, Nikita, Virenque, Anaïs, Koroleva, Kseniia, Eme-Scolan, Elisa, Teleman, Matei, Abdollahzadeh, Ali, Giniatullina, Raisa, Gafurov, Oleg, Krivoshein, Georgii, Malm, Tarja, Hämäläinen, Riikka, Sierra, Alejandra, Tohka, Jussi, Rua, Rejane, Noe, Francesco, Giniatullin, Rashid   +15 more
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