Results 41 to 50 of about 3,252 (154)
Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels [PDF]
Acta Neuropathologica Communications, 2020 AbstractSubdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. The meningeal lymphatic vessel (mLV) drainage pathway is a novel system that takes part in the clearance of waste products in the ...
Xuanhui Liu +15 more
openaire +3 more sources
eLife, 2017 Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta +10 more
doaj +1 more source
Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases
Frontiers in Neuroscience, 2022 The field of neuroimmunology endorses the involvement of the adaptive immune system in central nervous system (CNS) health, disease, and aging. While immune cell trafficking into the CNS is highly regulated, small numbers of antigen-experienced ...
Chiara Rickenbach, Christoph Gericke
doaj +1 more source
Overview of the meningeal lymphatic vessels in aging and central nervous system disorders
Cell & Bioscience, 2022 In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even ...
Huimin Jiang +5 more
doaj +1 more source
Mini review: Prospective therapeutic targets of Alzheimer's disease
Brain Circulation, 2022 Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease ...
RuchiMangal, YuchuanDing
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Established, New and Emerging Concepts in Brain Vascular Development
Frontiers in Physiology, 2021 In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta +2 more
doaj +1 more source
Fluid dynamics in aging-related dementias
Neurobiology of Disease, 2023 Recent human and animal model experimental studies revealed novel pathways for fluid movement, immune cell trafficking and metabolic waste clearance in CNS.
Thierno M. Bah +4 more
doaj +1 more source
Frontiers in Immunology, 2018 A hallmark feature of follicular dendritic cells (FDCs) within the lymph nodes (LNs) is their ability to retain antigens and virions for a prolonged duration.
Rajnish S. Dave +2 more
doaj +1 more source
The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans
Frontiers in Physiology, 2022 The human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper ...
Neel H. Mehta +14 more
doaj +1 more source
Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology
Advanced Science, EarlyView.Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen +12 more
wiley +1 more source