Results 41 to 50 of about 3,113 (145)
The Meningeal Lymphatic System: A New Player in Neurophysiology [PDF]
Neuron, 2018 The nature of fluid dynamics within the brain parenchyma is a focus of intensive research. Of particular relevance is its participation in diseases associated with protein accumulation and aggregation in the brain, such as Alzheimer's disease (AD).
Sandro, Da Mesquita +2 more
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The growth and expansion of meningeal lymphatic networks are affected in craniosynostosis [PDF]
Development, 2021 ABSTRACT Skull malformations are associated with vascular anomalies that can impair fluid balance in the central nervous system. We previously reported that humans with craniosynostosis and mutations in TWIST1 have dural venous sinus malformations. It is still unknown whether meningeal lymphatic networks, which are patterned alongside
Phillip S. Ang +2 more
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Scientific Reports, 2022 AbstractA system of lymphatic vessels has been recently characterized in the meninges, with a postulated role in ‘cleaning’ the brain via cerebral fluid drainage. As meninges are the origin site of migraine pain, we hypothesized that malfunctioning of the lymphatic system should affect the local trigeminal nociception.
Mikhailov, Nikita +15 more
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JCI Insight, 2022 The anatomical routes for the clearance of cerebrospinal fluid (CSF) remain incompletely understood. However, recent evidence has given strong support for routes leading to lymphatic vessels. A current debate centers upon the routes through which CSF can
Yann Decker +6 more
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Subdural haematomas drain into the extracranial lymphatic system through the meningeal lymphatic vessels [PDF]
Acta Neuropathologica Communications, 2020 AbstractSubdural haematomas (SDHs) are characterized by rapidly or gradually accumulated haematomas between the arachnoid and dura mater. The mechanism of haematoma clearance has not been clearly elucidated until now. The meningeal lymphatic vessel (mLV) drainage pathway is a novel system that takes part in the clearance of waste products in the ...
Xuanhui Liu +15 more
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eLife, 2017 Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta +10 more
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Specificity of Adaptive Immune Responses in Central Nervous System Health, Aging and Diseases
Frontiers in Neuroscience, 2022 The field of neuroimmunology endorses the involvement of the adaptive immune system in central nervous system (CNS) health, disease, and aging. While immune cell trafficking into the CNS is highly regulated, small numbers of antigen-experienced ...
Chiara Rickenbach, Christoph Gericke
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Mini review: Prospective therapeutic targets of Alzheimer's disease
Brain Circulation, 2022 Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease ...
RuchiMangal, YuchuanDing
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Overview of the meningeal lymphatic vessels in aging and central nervous system disorders
Cell & Bioscience, 2022 In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even ...
Huimin Jiang +5 more
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Established, New and Emerging Concepts in Brain Vascular Development
Frontiers in Physiology, 2021 In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta +2 more
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