Results 61 to 70 of about 3,212 (171)
, 2021 Highly developed meningeal lymphatics remove waste products from the brain. Disruption of meningeal lymphatic vessels in a mouse model of amyloid pathology (5XFAD) accelerates the accumulation of amyloid plaques in the meninges and brain, and causes ...
Park, Jiyoung +5 more
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Mini review: Prospective therapeutic targets of Alzheimer's disease
Brain Circulation, 2022 Alzheimer's disease is a neurological condition that causes the disruption of neuronal connections in the human brain. It is progressive and targets about 10% of the United States population over the age of 65.3 to date, there is no cure to the disease ...
RuchiMangal, YuchuanDing
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Overview of the meningeal lymphatic vessels in aging and central nervous system disorders
Cell & Bioscience, 2022 In the aging process and central nervous system (CNS) diseases, the functions of the meningeal lymphatic vessels (MLVs) are impaired. Alterations in MLVs have been observed in aging-related neurodegenerative diseases, brain tumors, and even ...
Huimin Jiang +5 more
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Established, New and Emerging Concepts in Brain Vascular Development
Frontiers in Physiology, 2021 In this review, we discuss the state of our knowledge as it relates to embryonic brain vascular patterning in model systems zebrafish and mouse. We focus on the origins of endothelial cell and the distinguishing features of brain endothelial cells ...
Ankan Gupta +2 more
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Fluid dynamics in aging-related dementias
Neurobiology of Disease, 2023 Recent human and animal model experimental studies revealed novel pathways for fluid movement, immune cell trafficking and metabolic waste clearance in CNS.
Thierno M. Bah +4 more
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The Brain-Nose Interface: A Potential Cerebrospinal Fluid Clearance Site in Humans
Frontiers in Physiology, 2022 The human brain functions at the center of a network of systems aimed at providing a structural and immunological layer of protection. The cerebrospinal fluid (CSF) maintains a physiological homeostasis that is of paramount importance to proper ...
Neel H. Mehta +14 more
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Brain, Behavior, & Immunity - Health, 2023 The interaction between the central nervous system (CNS) and the peripheral immune system is key for brain function in homeostasis and disease. Recent studies have revealed that the C–C chemokine receptor 7 (CCR7) is expressed in both CNS resident cells ...
Gisel Flores-Montoya +7 more
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Conserved meningeal lymphatic drainage circuits in mice and humans
Journal of Experimental Medicine, 2022 Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of the dura mater, where they ensure waste product elimination and immune surveillance of brain tissues. Whether MLVs exist in the anterior part of the murine and human skull and how they connect with the glymphatic system and extracranial lymphatics remained ...
Jacob, Laurent +16 more
openaire +2 more sources
Frontiers in Immunology, 2018 A hallmark feature of follicular dendritic cells (FDCs) within the lymph nodes (LNs) is their ability to retain antigens and virions for a prolonged duration.
Rajnish S. Dave +2 more
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Mapping meningeal vasculature in non-human primates
Veins and Lymphatics, 2022 Background. The blood-brain barrier has been the focus of most prior work examining intracranial vasculature in the context of various brain diseases.1 Recently, meningeal vasculature has become more widely recognized as a key contributor to brain ...
Christopher Janson +4 more
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